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13 Cards in this Set
- Front
- Back
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Short term treatment of asthma involves which two classes of drugs? |
Sympathomimetics (B2 agonists & antimuscarinic)
Methalxanthines |
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Long term controllers of asthma involve which three classes of drugs? |
Inhaled corticosteroids Leukotriene antagonists Mast cell stabilizers |
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Asthma is mediated by which class of antibodies? |
IgE |
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What role do mast cells play in asthma? |
IgE bound to mast cells trigger degranulation and release of chemical mediators. |
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Which chemical mediators are responsible for "early asthmatic respnse"? |
Histamine Tryptase Leukotriene C4, D4 Prostaglandin D2 |
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When is the "late asthma response" seen? |
4-6 hours after the initial bronchospasm |
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What is responsible for the "late asthma response?" |
Cytokines released by inflammatory cells that have migrated into the bronchial mucosa. |
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What is a normal FEV1 value? |
Approximately 80 % of vital capicity |
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What is nonspecific bronchial hyperreactivity? |
Bronchospasm NOT triggered by allergin -cold air -viral respiratory infection -exercise |
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What causes nonspecific bronchial hyperreactivity? |
Related to chronic inflamation of airway mucosa |
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Describe the sympathetic nervous pathway in the lung? |
B2 receptor - adenylate cyclase- increased cAMP (bronchodialation, increased cilliary movement, decreased release of mediators from mast cells) |
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Describe the parasympathetic nervous pathway in the lung. |
Vagus nerve- ACh - muscarinic receptor - (bronchoconstriction, mucous hypersecretion) |
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Describe three hallmarks of obstructive disease: |
-Decresed FEV1 -slightly decreased to normal FVC -reduced ratio of |
