Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
35 Cards in this Set
- Front
- Back
what are the RF of breast cancer
|
increasing age >60
genetic especially when <45 there is a 1.5-3 x increase alterations BRCA HER2neu hormonal no preg, late menopause, early menarche, physical inactivity, obesity, alcohol |
|
what makes a better chance of not contracting breast cancer
|
late period, early menopause
|
|
how is alcohol a RF for breast cancer
|
it increases estrogen from increased folic acid
|
|
how do you screen for breast cancer
|
self every month after year 20 right after period
clinically q 3 yrs 20-39 and q year anually 40+ yrs mammogram anually 40+ |
|
how can you prevent breast cancer
|
surgery in high risk if benefits>risks
- tamoxifin |
|
what are types of invasive breast cancer
|
ductal
lobular inflammatory breast |
|
how can you tell if it is ductal invasive cancer
|
prominent unilateral lump
|
|
how can you tell it it is lobular invasive breast cancer
|
thickening of breast
|
|
how can you tell if it is inflamm breast cancer
|
skin edema, redness, warmth
|
|
what the types of non-invasive breast cancer
|
ductal carcinoma insitu
and lobular carcinoma in situ |
|
how can you tell it is non-invasive ductal carcinoma in situ
|
small non-palpable lesions
|
|
how can you tell it is non-invasive lobular corcinoma in situ
|
non-gross abnormality
|
|
how do you determine tumor size
|
1 is <2cm, 2 is >2 cm <5cm, T3 is >5 cm
|
|
how do you determine number of luymph nodes
|
N1 - 1-3 axiallary, N2 - 4-9 axiallary or mammery, N3 - >10 axiallary, intraclavivular, supraclavicular
|
|
what stage is metastasis
|
stage 4
|
|
what is the stage for carcinoma in situ
|
stage 0
|
|
what are the biomarkers and what do they say about the cancer
|
ER/PR +, means less aggressive
|
|
what does HER2/neu positive mean
|
more aggressive
|
|
what do you treat with HER2/neu positive
|
trastuzumab
|
|
what is the treatment of stage 0,1,2,
|
goal is to cure with surgery, taxanes, anthracyclines, cyclo, methotrexate, or FU (best is doxo +cyclo)
|
|
what is the superior treatment fo stage 0,1,2
|
AC for 4 cycles followed by paclitaxel 4 cycles
|
|
what is the treatment for ER/PR+ stage 0,1,2
|
tamoxifen
|
|
what are aromatase inh used for
|
ER/PR+
|
|
what is the treatment for stage 3
|
neoadjuvant chemo
|
|
what is the treatment for stage 4 ER/PR+
|
aromatase inh
|
|
what are the ADR of trastuzumab
|
Black box- hypersens, cardiomyopathy
|
|
what is the MOA of trastuzumab
|
humanized monoclonal antibody to HER2neu receptor protein
|
|
what is the dose of trastuzumab
|
4mg/kg IV over 90 min on Day 1
and 2mg/kg over 30 min q week |
|
what is the treatement for pre-menopausal woman
|
LHRH plus tamoxifen
|
|
what is the MOA of tamoxifen
|
competitively block estrogen receptor, estrogen agonist at bone, lipids, and endometrium; estrogen antagonists at breast and vaginal mucosa
|
|
what is the dose of Tamoxifen
|
20 mg daily
|
|
what are the ADR of tamoxifen
|
hot flashes, fluid ret, thrombotic events, endometrial cancer
|
|
what is the MOA of aromatase inhibitors
|
inhibit or inactivate aromatase - suppress plasma estrogen levels
|
|
dose for anastrazole, letrozole, exemestane
|
1mg, 2.5mg, 25mg po
|
|
ADR of aromatase inh
|
asthenia, athralgias, hot flashes, long-term osteoporosis
|