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121 Cards in this Set

  • Front
  • Back

head fold


1)


2)

ventral "swing" of heart and oropharyngeal membrane


closure of foregut

formation of branchial apparatus:


1)


2)

1) neural crest cells


2) cephalic paraxial mesoderm

source of all connective tissues including skeleton

neural crest cells

source of all skeletal muscles

cephalic paraxial mesoderm

if drugs/alcohol is involved, you usually see problems in the

face

branchial apparatus includes these 4 things:

branchial arches


branchial grooves


branchial pouches


branchial membrane

there are ____ branchial arches

6

the __ arch is separated into 2 prominences: ___ & ___

first


maxillary


mandibular

there are ___ external grooves separating each arch

4

ectodermal lined depression

stomodeum

separated from foregut by

oropharyngeal membrane

forms the anterior 2/3 of the tongues

stomodeum

the remnant of the oropharyngeal membrane

palatoglossal arch

four internal evaginations of endoderm separating each branchial arch

pharyngeal pouches

meeting of ectoderm of branchial groove w/ endoderm of pharyngeal pouch

branchial membrane

3 structural components of a typical branchial arch

ectodermal outer covering


endodermal inner lining


mesenchymal core

ectodermal outer covering

epidermis

endodermal inner lining

mucosal

mesenchymal core

branchiomeric mesenchyme

mesenchymal core contains:

1) blood vessel (endothelium of an aortic arch)


2) cartilaginous bar (forms from neural crest cells)


3) muscular component (forms from cephalic paraxial mesoderm (somitomeres))


4) cranial nerve

the cartilage in each arch that forms from neural crest cells give rise to

adult structures

branchial groove 1 gives rise to

external acoustic canal

branchial grooves 2-4 give rise to

cervical sinus


(usually regresses)

maxillary does/doesn't have cartilage associated w/ it

does not

1) Meckel's cartilage


2) dorsal part forms malleus & incus by _____ ossification


3) ventral portion regresses


4) _____ forms by intramembranous ossification

mandibular prominence



-endochondral


mandible

forms maxilla, zygomatic bone, & squamous portion of temporal bone by intramembranous bone formation

maxillary prominence

branchial arch 1 gives rise to:

mandibular prominence


maxillary prominence

malleus, incus, and mandible come from which arch

arch 1

maxilla, zygomatic bone, and squamous portion of temporal bone come from which arch

arch 1

has


- Reichert's cartilage


- forms stapes, styloid process, upper 1/2 of hyoid bone by endochondral bone formation

branchial arch 2

which arch forms lower half of hyoid bone (by ____ bone formation)

branchial arch 3


endochondral

which arches form cartilage of larynx (except epiglottis)

arches 4 & 6

branchial arch 1 innervation

maxillary & mandibular divisions of trigeminal nerve (V2, V3)

branchial arch 2 innervation

facial nerve (CN VII)

branchial arch 3 innervation

glossopharyngeal n (CN IX)

branchial arch 4

superior laryngeal branch of vagus nerve (CN X)

branchial arch 6 derived structures innervation

recurrent laryngeal branch of vagus nerve (CN X)

branchial muscles come from

cephalic paraxial somitic mesoderm

branchial muscles innervation

efferent branches of cranial nerves to branchial arches

arch ___:


muscles of mastication


mylohyoid


anterior belly of the digastric


tensor tympani


tensor veli palatini

branchial arch 1

branchial arch 1 innervation

V3

arch __ :


muscles of facial expression


stylohyoid


posterior belly of the digastric


stapedius

arch 2

branchial arch 2 innerv

VII

arch __:


stylopharyngeus

arch 3


arch 3 innerv

IX

arch __ :


cricothyroid


levator veli palatini


constrictors of pharynx


palatoglossus

4

arch 4 innerv

superior laryngeal branch of vagus

arch __:


intrinsic muscles of larynx

6

arch 6 innerv

recurrent laryngeal branch of vaugs

- tubotympanic recess


- forms pharyngotympanic canal & cavity of middle ear

pharyngeal pouch 1

epithelium of palatine tonsil and tonsilar crypts

pharyngeal pouch 2

-dorsal portion- inferior parathyroid glands


- ventral portion- epithelial reticulum of thymus gland

pharyngeal pouch 3

-dorsal portion- superior parathyroid glands


-ventral portion


1) ultimobranchial body


2) associates w/ neural crest cells to form


parafollicular (c-cells) of thyroid gland


pharyngeal pouch 4

pharyngeal pouch structures develop ____

bilaterally

thyroid gland is _____ derived form pharyngeal pouches!

not

Thyroid diverticulum


1. endodermal-lined evagination


2. just ____ to median tongue bud


3. ________ (proximal opening of thyroglossal duct)

caudal


foramen cecum

Descent of thyroid gland into neck


1) ____ (narrow tube connecting thyroid gland to tongue)


2) ___ structure


3) most ____ structure


thyroglossal duct


midline


anterior

diverticulum- ___ and ____ down tongue and into neck

expands


elongates

thyroid gland is/isn't derived from branchial apparatus

is not

congenital malformations of Thyroid gland

1) thyroglossal duct cyst


2) thyroglossal duct sinus


3) ectopic thyroid gland

cyst in thyroglossal duct can form an opening on surface

thyroglossal duct sinus

when the thyroid doesn't descent to normal position, can be located anywhere along the path of descent

ectopic thyroid gland

sites of ectopic thyroid tissue

lingual thyroid


foramen cecum of tongue


accessory thyroid tissue


pyramidal lobe of thyroid gland

these two sites of ectopic thyroid tissue are associated with downs syndrome

lingual thyroid/forame cecum

most common congenital cause of a neck mass

branchial cleft cysts

accounts for 20% of all neck masses in children (2-3% of cases are bilateral)

branchial cleft cysts

branchial malformations include

- branchial sinus, fistula or cyst


-first arch syndrome


- digeorge syndrome


- ectopic glandular tissue

remnant of cervical sinus


not midline structures

branchial sinus, fistulas or cysts

branchial malformations are ___

lateral

cervical sinus would be along the ____

sternomastoid

complete branchial fistula connects pharynx w/ ___

exterior

- malformations of the ear, mandible, zygoma and palate


- due to insufficient migration of neural crest cells into the first branchial arch

first arch syndrome

DiGeorge Syndrome:


1) lack of ____ glands and ___ glands


2) facial abnormalities: ___ ears, ___ mouth


3) defects in ___ of heart and great vessels

parathyroid, thmus


low-set, small


outflow tract

the development of all the organs involved in Digeorge syndrome is dependent on ________ to the region of _______

migration of neural crest cells


pharyngeal pouches

all pouches are derived from

endoderm

neural crest defect would affect just as much as endoderm defect

true


stomodeum


1. ___ depression


2. forms ______ of oral cavity


3. ___ pouch- anterior lobe of pituitary; glandular outgrowth of ectoderm from the stomodeum of the embryo


4. oropharyngeal membrane

ectoderm-lined


anterior 2/3


Rathke's

all of the face is mostly associated w/ which arch

1

frontal prominence of head includes

head/forehead region

rathke's pouch (aka hypopysial diverticulum) gives rise to

anterior pituitary

five facial primordia

frontonasal prominence


maxillary prominences (paired)


mandibular prominences (paired)

the 5 facial prominences are formed from the proliferation and migration of _____

neural crest cells

the ____ is the major source of connective tissue components, including cartilage, bone, and ligaments in the ___ and ____ regions

neural crest


face


oral

stomodeum


five facial primordia


nasal placodes


medial and lateral nasal prominences


nasolacrimal groove


intermaxillary segment


cutaneous sensory innerv


muscles of facial expression

development of face

nasolacrimal groove:


forms between ______ processes and adjacent ____ swelling

lateral nasal


maxillary

placode =

thickening of surface ectoderm

nasal placodes begin to indent and form ___

pits

you have ___ and ___ nasal prominences around the pits

medial


lateral

pits migrate ____ toward each other

medially

you can see clefts in babies between the ____

pits

nasolacrimal groove:


connects ___ side of eye w/ ____

medial


nasal cavity

formed by fusion of paired medial nasal prominences

intermaxillary segment

forms philtrum of lip


fleshy nasal septum


premaxillary part of maxilla


primary palate

intermaxillary segment

intermaxillary segment forms ____ palate

primary

extension of intermaxillary segment

primary palate

frontonasal prominence innerv

V1


(ophthalmic division of trigeminal)

maxillary prominence innerv

V2


(maxillary div of trigeminal)

mandibular prominence innerv

V3


(mandibular ldiv of trigeminal)

face has sensory inner by branches of the

trigeminal

muscles of facial expression are located in _____ (hyoid) branchial arch

second

muscles of facial expression are inner by

facial nerve (VII)

muscles of facial expression associated w/ arch __

2

nasal pits and sacs:


______ - lined depressions

ectoderm

oronasal membrane:


1. rupture of _____


2. continuity between ____ and ___ cavities

membrane


nasal, oral

development of palate:


primary and secondary palate

primary palate:


forms as part of _____ segment

intermaxillary

secondary palate:


- forms as ___ shelves (lateral palatine processes) that lift from ____ prominences

paired


maxillary

secondary palate:


forms by fusion of:

paired lateral palatine process and nasal septum

formed from neural crest in frontonasal and medial nasal processes

nasal septum

separates oral and nasal cavities (except in region of pharynx)

palate

shelves grow from proliferation of ____

neural crest cells

primary palate forms from

intermaxillary segment

secondary palate forms from

palatal shelves & nasal septum

incisive foramen is landmark between ___ and ___ palate

primary and secondary

makes up majority of adult palate

secondary palate

anterior cleft malformations:


1. cleft ___


2. incomplete fusion of _____ with _____

lip


maxillary prominence, medial nasal prominence

posterior cleft malformation:


1. cleft ____


2. incomplete fusion of ______ and ____

palate


lateral palatine processes, nasal septum

epidemiology of cleft lip:


1/1000 births


occurs more frequently in ____ (80%)


incidence increases slightly w/ ____ age

males


maternal

epidemiology of cleft palate:


- 1/2500 births


- occurs more frequently in ___ (67%)


(palatal shelves fuse 1 week later in them)


- not related to maternal age


females

______ drugs (phenobarbital and diphenylhydantoin) during pregnancy increases risk of cleft lip and cleft palate

anticonvulsant


causes of cleft palate:


- _____ of palatal shelves


-failure of shelves to _____


-inhibition of the fusion process itself


- failure of the ___ to drop btwn the shelves because of microagnathia

smallness


elevate


tongue