Brain Tumor Buzz Words

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MC primary brain tumor in adults

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Gliobastoma multiforme

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less than 1 year life expectancy

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Gliobastoma multiforme

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can cross corpus callosum

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Gliobastoma multiforme

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pseudopallisading necrosis

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Gliobastoma multiforme

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GFAP +

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Gliobastoma multiforme and pilocytic astrocytoma

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most often location for brain tumors in kids? adults?

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kids = infratentorial

adults = supratentorial

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2nd MC brain tumor in adults

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meningioma

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arises from arachnoid cells external to the brain

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meningioma

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spindle cells concentrically arranged in a whorled pattern

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meningioma

(this is the description of a psamomma body)

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psammoma body

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meningioma

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3rd MC brain tumor in adults

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schwannoma

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seen with NF2

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bilateral schwannoma

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S-100 positive

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schwannoma

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ppx with tinitis and hearing loss

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schwannoma

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slow growing, often found in frontal lobes

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oligodendroglioma

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chicken wire capillary pattern

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oligodendroglioma

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fried egg appearance

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oligodendroglioma

this is described as perinuclear clearing

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perinuclear clearing or round nuclei with clear cytoplasm

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oligodendroglioma

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most commonly presents as a prolactinoma

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pituitary adenoma

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bitemporal hemianopia

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pituitary adenoma

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bitemporal hemianopia

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pituitary adenoma

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embryologic origin from rathke's pouch

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pituitary adenoma

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MC child hood brain tumor

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pilocytic astrocytoma

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GFAP (+)

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pilocytic astrocytoma and GBM

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eosinophilic, corkscrew fibers that appear cystic and solid on gross exam

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pilocytic astrocytoma

(description of rosenthal fibers)

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rosenthal fibers

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pilocytic astrocytoma

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highly malignant cerebellar tumor in children

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medulloblastoma

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can compress 4th ventricle and lead to hydrocephalus

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medulloblastoma and hemangioblastoma

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homer-wright pseudorossette pattern

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medulloblastoma

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the extra-colonic association with turcot's (FAP +1)

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medulloblastoma

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cells lined up adjacent to each other around a "tangle of material"

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medulloblastoma

(describes a homer-wright pseudorossette)

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cells lined up adjacent to each other around a "vascular structure"

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ependymoma

(describing perivascular pseudorossette)

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perivascular pseudorossettes

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ependymoma

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rod shaped blepharoplasts (basal ciliary bodies) found near nucleus

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ependymoma

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asocaited with von Hippel Lindau disease when found with retinal angiomas

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hemangioblastoma

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cab produce EPO leading to secondary polycythemia

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hemangioblastoma

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foamy cells and high vascularity

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hemangioblastoma

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most common childhood supratentoral tumor

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cranipharyngioma

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tooth enamel-like calcification

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craniopharyngioma

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derived from rathke's pouch

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craniopharyngioma and pituitary adenoma