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8 Cards in this Set
- Front
- Back
ACE inhibitor effect on bradykinin
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Inhibits degradation of bradykinin, increasing its activity
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Bradykinin effect
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algesic agent, vasodilator, "wheal and flare" due to increased vascular permeability, not antagonized by antihistamines, indirectly increases cardiac output and heart rate, promotes prostaglandin release by kidneys, associated with acute inflammation, shock, anaphylaxis
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Bradykinin structure
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Nona-peptide (nine amino acids). Converted from high molecular weight kininogen by a plasma enzyme, kallikrein.
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One of the other kinins
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Lysylbradykinin. Enzyme that forms it is kallidin.
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Renin-Angiotensin System
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Renin converts angiotensinogen to angiotensin 1. ACE converts angiotensin 1 to angiotensin 2, along with angiotensin 3 it works at ATII receptors.
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Enzyme that metabolizes bradykinin
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Peptidyl dipeptidase (Angiotensin-converting enzyme or ACE)
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Kallikrein
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Plasma enzyme that converts high molecular weight kininogen to bradykinin.
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Aprepitant
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Emend- non-peptide antagonist at the NK1. Used for nausea and vomiting due to chemotherapy.
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