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27 Cards in this Set
- Front
- Back
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Mutation in CML?
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ABL - translocation 9:22
(Philadelphia chromosome) |
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Mutation in breast cancer?
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HER - amplification of receptor synthesis
(marker for aggressiveness) |
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Mutation in Burkitt's lymphoma?
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MYC - translocation 8:14 of nuclear transcription
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Mutation of Neuroblastoma?
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N-MYC - amplification of nuclear transcription
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Point mutation seen in Leukemia, lung, colon, pancreatic carcinomas?
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RAS - point mutation of signal transduction
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Mutation seen in endocrine neoplasia?
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RET - receptor synthesis
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Mutation seen in oseogenic sarcoma and astrocytoma?
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SIS - over expression of growth factor
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Mutation seen in familial polyposis (colorectal carcinoma)
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APC - suppressor gene that prevents nuclear transcription
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Mutation associated with breast, ovary and prostate cancers?
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BRCA - tumor suppressor gene that regulates DNA cells
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Mutation seen in retinoblastoma, osteogenic sarcoma and breast carcinoma?
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RB gene - tumor suppressor that inhibits G to S
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Mutation involved in pancreatic and colorectal carcinomas?
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TGF-beta - tumor suppressor of G to S
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mutation of this gene is involved in Li-Fraumeni syndrome?
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TP 53 - breast carcinoma, brain tumors, leukemia and sarcomas
suppressor to G to S, repairs DNA and activates BAX |
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gene mutation in Von Hippel-Lindaue syndrome?
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VHL - regulates nuclear transcription
cerebellar hemangioblastoma, retinal angioma, renal cell carcinoma and pheochromocytoma |
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Mutation in Wilms' tumor?
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WT1 - regulates nuclear transciption
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Aflatoxin causes?
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hepatocellular carcinoma associated with hep B virus and from Aspergillus
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Alcohol causes?
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SCC of oropharynx and esophagus
pancreatic and hepatocellular carcinoma |
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Arsenic causes?
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SCC of skin
lung cancer liver angiosarcoma |
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Asbestos causes?
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bronchogenic carcinoma
pleural mesothelioma |
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Benzene causes?
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acute leukemia
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Beryllium, Chromium, Silica or Nickel cause?
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bronchogenic carcinoma
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oral contraceptives cause?
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breast and cervical carcinomas
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Polycyclic Hydrocarbons cause?
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SCC of oral cavity, esophagus, larynx and lung
adenocarcinoma of esophagus and pancreas transitional carcinoma of bladder and renal pelvis |
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Polyvinyl Chloride?
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liver angiosarcoma
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Radiation causes?
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Leukemia
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Cyclophosphamide and Beta-naphthylamine (alanine dyes) cause
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transitional cell carcinoma of the urinary bladder
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EBV causes?
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8:14 translocation promoting B-cell proliferation. Burkitt's lymphoma, CNS lymphoma, Hodgkins Lymphoma, nasopharyngeal carincoma
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HPV causes?
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squamous cell carinoma of vuvla, vagina, cervix, anus (anal intercourse), larynx, and oropharynx
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