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13 Cards in this Set

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Bordetella pertussis

Distinctive Properties:
(1) causes what condition?
(2) highest incidence in which age group?
(3) gram stain
(4) oxygen requirement
(5) highest mortality in which age?
(1) Whooping cough
(2) <1 year, adolescent, adult
(3) gram-neg
(4) aerobic
(5) <6 mos
Bordetella pertussis

Pathogenesis:
(1) outer memb proteins
(2) exotoxins
(3) endotoxins
(1) filamentous hemagglutinin,
fimbriae,
pertactin
(2) pertussis toxin (PT),
adenylate cyclase toxin (CyaA),
dermonecrotic toxin (DNT)
(3) trachael cytotoxin (TCT), LPS
Bordetella pertussis

Host Response:
(1) duration of symptoms
(2) antibiotic treatment
(3) events during disease
(1) until affected cells shed
(2) can't reduce duration
(3) lymphocytosis, incr mucus prod, bronchopneumonia
Bordetella pertussis

Treatment:
(1) why only supportive care?
(2) when are antimicrobials useful?
(3) examples of immunoprophylaxis
(1) no antitoxins available
(2) early in disease
(3) DTP, DTap
Neisseria meningitidis:
Infections (4)
(1) meningitis
(2) bacteremia
(3) pneumonia
(4) septic arthritis
Neisseria meningitidis

Pathogenesis:
(1) what route?
(2) how long before disseminate via bloodstream?
(3) endotoxin + effects
(1) resp (nasopharynx)
(2) 2 weeks
(3) lipid A of LOS -> DIC, vasc collapse/shock, hemorrhage
Neisseria meningitidis

Host Response:
(1) antibodies to what?
(2) fatality rate
(3) possible sequelae
(1) capsular antigen
(2) 10-12%
(3) CNS, multiorgan fail, limb necrosis
Neisseria meningitidis

Treatment:
(1) antibiotics
(2) chemoprophylaxis
(3) immunoprophylaxis
(4) vaccine
(1) usually penicillin
(2) rifampin
(3) capsular polysac against type A, C, Y, W135
(4) tetravalent conjugate vaccine
Neisseria meningitidis

Epidemiology:
(1) Five serotypes
(2) which causes disease in infants?
(3) which causes disease in adolescents, adults?
(4) what facilitates invasion?
(5) what predisposes to severe infection?
(1) A, B, C, Y, W135
(2) infants = B
(3) adults = C, Y, W135
(4) viral infection
(5) complement deficiency, no spleen
Neisseria gonorrhoeae

Disease in...:
(1) males
(2) females
(3) newborns
(1) gonorrhoeae, epididymitis
(2) cervictis, urethritis, PID
(3) conjunctivitis, sepsis
Neisseria gonorrhoeae

Pathogenesis:
(1) colonize where?
(2) LOS causes what?
(1) columnar epithelium of urethra
(2) sloughing of cilia, inflamm response
Neisseria gonorrhoeae

Host Response:
(1) which cells infiltrate?
(2) antibodies to what?
(1) neutrophils, macros, lymphs
(2) LOS, pili, outer memb proteins
Neisseria gonorrhoeae

Treatment:
(1) Resistance
(2) Prevention in newborns
(1) penicillin, some to tetracycline
(2) eye drops