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8 Cards in this Set
- Front
- Back
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What are drug combos for ALL? Hodgkins?
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ALL:
Prednisone + Vincristine POMP - Prednisone, Oncovin (vincristine), Methotrexate, Purimethol Hodgkins: MOPP - Mechlorethamine, oncovin, prednisone, procarbazine ABVD - adriamycin, bleomycin, vinblastine, dacarbazine (most commonly used) |
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What are the specific side effects for cyclophosphamide? Bleomycin? Cisplatin? L-asparaginase?
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cyclo - hemorrhagic cystitis can progress to bladder fibrosis
cisplatin - peripheral neuropathy bleomycin - pulmonary fibrosis L-asp - hypersensitivities |
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What is a DOC for ALL?
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6-MP - interferes with nucleic acid - severe bone marrow suppression
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What is Cisplatin used for?
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testicular and bladder cancer.
SE - damage to nervous system and kidneys. strongly emetic |
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What is Tamoxifen used for?
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it inhibits estrogen receptors in breast tissue. Used in treatment of breast cancer and prophylactically in women who are at high risk for breast cancer.
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What does NSAIDs do to alleviate pain?
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inhibits the production of PGE2.
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How does aspirin work?
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acetylates cyclooxygenase irreversibly - permanent inhibition of cyclooxygenase.
minimizes inflammation Also decreases fever since it works in hypothalamus Reduces coagulation tendency - thromboxane not formed |
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How does acetaminophen work?
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inhibits cyclooxygenase
no peripheral anti-inflammatory action. Limited to mostly CNS - reducing fever and pain perception. DOC for children with viral infections but without the risk aof inducing Reyes syndrome like aspirin. |
