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12 Cards in this Set
- Front
- Back
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What happens when more than 1 drug compete for renal transporters?
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Higher levels of the active drug are seen in the body because there are limited numbers of renal transporters to remove the drug.
This is especially true for neonates and premies since their tubular secretory mechanisms aren't fully developed |
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Which drug is an antibiotic that inhibits bacteria transcription (inhibits reading of DNA to make RNA)
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Rifampin
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Which drug is an antibiotic that is a protein synthesis inhibitor?
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Chloramphenicol
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Which drug inhibits renal excretion of uric acid at lower doses, but at higher doses will increase uric acid secrtion?
Known as uricosuric at high doses Lower doses are used to treat gout and hyperuricemia (wiki) |
Probenecid
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Which drugs will worsen gout by increasing uric acid levels in patients with Gout?
they also increase serum levels of drugs by competing at the PCT. |
Some Pharmaceuticals Plus Urate Stop Transporters
Sulfonamides Probenecid Penicillin Urate Salicylates Thiazides |
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What drug combinations will increase the risk of Serotonin Syndrome?
Neophrotox and Ototox of aminoglycosides are accentuated by what? |
MAO inhibitors with SSRI's
MAO inhibitors with TCA's Loop Diuretics |
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Bone Marrow Tox
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chemothreapeutic agents
chloramphenicol ganciclovir zidovudine (AZT) interferon flucytosine carbamazepine |
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Heptatotox
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all imidazoles
interferon nevirapine HMG CoA inhib valproic acid isoniazid |
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nephrotox
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amigolycosides
foscarnet cidofovir NSAID cyclosporine amphotericin |
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What drug that is an anesthetic used during surgery will cause malignant hyperthermia and body-side spasms?
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Halothane
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What 2 drugs are used to treat CMV retinitis?
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Foscarnet - nephrotox
cidofovir - DOC for smallpox and sever adenovirus infection - bone marrow tox |
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What drug will treat BPH and alopecia? This drug is also likely to cause a decreased libido and erectile dysfunction.
What drug will be used to manage erectile dysfunction? |
5-alpha reductase inhibitor
PDE-5 inhibitors - permanent blindness and hearing loss (rare) |
