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17 Cards in this Set
- Front
- Back
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amantadine
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impairs uncoating of virus - can't release virus - by finding to influenza A's M2 matrix
Influenza A if in 1st 48 hours of symptoms |
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Interferon
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inhibit viral RNA translation an dinduces MHC-1 expression - increase sensitivity towards and ability to eradicate virally infected cells.
chronic HBV/HCV and hairy cell leukemia |
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Ribavirin
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blocks viral mRNA synth.
DOC - chronic HCV |
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Acyclovir
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inhibition of DNA polymerase
premature DNA chain termination DNA synth inhibitor needs viral thymidine kinase to be active. HSV1/2, VZV, EBV not for CMV penetrates BBB |
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Vidarabine
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inhibit DNA synth
all herpes groups - especially herpes encephalitis and VZV in immunocomp pts 2nd line for herpes keratits when in ointment form |
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Ganciclovir
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inhibition of DNA polymerase
premature DNA chain termination viral thymidine kinase not required CMV treated used with valganciclovir for CMV retinitis. BM suppression is common SE |
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AZT
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viral DNA synth inhibitor
treat HIV BBB penetration NRTIs - inhibit viral DNA synth - didanosine, stavudine, lamivudine |
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Protease inhibitor
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inhibit cleavage of giant protein that HIV cut apart to have functional components of that protein
HIV infections - saquinavir, ritonavir, indinavir, nelfinavir, fosamprenavir |
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NNRTIs
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inhibit reverse transcriptase
HIV infections nevirapine, delavirdine, efavirenz |
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Fusion inhibitors
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prevent fusion between HIV virion and the cell
binds to gp41 and prevents viral fusion with cells membrane - preventing entry enfuvirtide |
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integrase inhibitors
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inhibit the HIV viral integrase enzyme - preventing integration and insertion of HIV DNA into human DNA
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CCR5 antagonists
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block CCR5 co-receptor on WBC that are targeted by HIV. Prevents HIV entry.
CCR5-tropic HIV1 |
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Neuraminidase inhibitors
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inhibit influenza virus neuraminidase
influenza A and B |
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Foscarnet
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inhibitor of both DNA polymerase and reverse transcriptase
alternative to ganciclovir for CMV Gan-resistant CMV effective against HIV nephrotox |
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valganciclovir
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combo with ganciclovir for CMV retinitis
sone marrow suppression |
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Trifluridine
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inhibit viral DNA synth. does not require thymidine kinase
HSV DOC for herpese keratitis solution form |
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Cidofovir
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suppresses viral rep by inhibition of viral DNA synth
alt for CMV retinitis DOC - smallpox, severe adenovirus infections SE - extremely nephrotoxic - Fanconi syndrome (prox conv tubule destructio) teratogenic |
