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8 Cards in this Set
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Hematopoetic stem cells |
immature cells that can develop into blood cells
source are bone marrow, circulating stem cells, and umbilical cord blood |
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Types of transplant |
allogenic = non-self
autologous = own cells
not always for malignant disease |
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When auto when allo |
autologous when the stem cells are normal and you want to give high doses of chemo then rescue the patient, seen in late differential diseases
allogenic, patients stem cells are abnormal |
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Autologous |
collect stem cells and freeze then chemo hardcore kill the marrow then reinfuse peripherally and set up shop |
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Variables in allogeneic transplants |
success depends on; recipient; age donor; age preparative regimen stem cell source prophylaxis against GVDH post transplant supportive care |
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most common disease for autologous transplant |
multiple myeloma #1 high grade NHL/HD at time of relapse
most common allogeneic is done in AML |
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Allogeneic in SCIDS and Willcott Aldrich |
do very well, where as in cancers come back, these genetic disorders can be fixed
underlying disease and quality of donor match matters, want young donors and recipients |
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Complications of transplant |
infections; average time to immune recovery, neutrophils and phagocytes 1 month, T cells and B cels 6-12 and 12-4 respecitively
graft vs host disease some degree can be good in graft vs leukemia
graft failure
hepatic veno occlusive diseaes
pulmonary
late complications |
