Bone Formation

Front 1

bone formation methods

Back 1

intramembranous ossification - bone forms directly from embryonic membranes
endochondral bone formation - bone forms indirectly from cartilaginous templates

Front 2

intramembranous ossification steps

Back 2

used for non weight bearing bones
1. embryonic mesenchymal cells condense into a connective tissue "membrane" with increased vascularization
2. osteoblasts differentiate from the mesenchymal cells

Front 3

intramembranous ossification steps

Back 3

3. calcium phosphate salts become incorporated (blasts become cytes)
4. spicules develop forming bony meshwork. spaces filled with bone marrow cells and blood vessels
5. spongy bone core of flat bone retains its trabecular appearance and remodelling is continual by clasts and blasts

Front 4

Endochondral ossification

Back 4

forms most of the bones in the body. forms long bones. forms from cartilage model

Front 5

Steps of endochondral ossification

Back 5

1. hyaline cartilage forms template
2. calcification tears down cartilagenous tissue
3. mineralization (pg 117 on 13)
4. invasion of blood vessels. chondrocytes die, osteogenic invade
5.