Bone And Joint Pathology

Front 1

Osteosarcoma - features

Back 1

Location - metaphysis, proximal humerus, distal femur, prox tibia
Age 10-25, .40yrs
Xray - mixed lucent & opaque
Cortical destuction & soft tissue extension

Front 2

Parosteal osteosarcoma

Back 2

slightly older
juxtacortical
posterior aspect lower femoral shaft
grows slowly
encircles bone
Well-formed bone, osteoid, occs cartilage, highly fibrous spindle cell stroma (subtle atypia)
intraosseous component is separated from medullary space of bone (vs osteochondroma)
lacks osteoblastic rimming (FD)
excellent prognosis - completely excised - if not possible dedifferntiation

Front 3

Enchondromas

Back 3

small bones hands & feet

Front 4

Chondrosarcoma

Back 4

large flat bones axial skeleton
# 2 malignant neoplasm of adult bone
XRAY -endosteal scalloping, cortical thickening, soft tissue mass
celluarity, atypia, nuclear pleomorphism
de novo
wide surgical excision

Front 5

myxoid chondrosarcoma

Back 5

soft tissue or bone
monotonous proliferation of uniform, relatively small cells, pink cytoplasm, vesicular nuclei
myxoid stroma
late recurrences & mets

Front 6

mesenchymal chondrosarcoma

Back 6

biphasic
jaw & ribs young adults
small immature mesenchymal cells , foci of well-differentiated cartilage & hemangiopericytoma like vessels

Front 7

chordoma

Back 7

low metastatic rate
occurs 6th decade
clinical -severe constipation and presacral mass
lobulated architecture
solitary large central expansile lucency

Front 8

MFH

Back 8

primary bone or soft tissue
femur, tibia, humerus, & pelvis
ill defined radiolucency
fascicular growth with storiform patterns

Front 9

Nonossifying fibroma

Back 9

Metaphysis children, long bones lower extremities
xray - small-well defined intracortical radiolucency (fibrous corticl defect) or as eccentric lucency (cyst)
Micro: slender spindle cells storiforming, giant cells, hemosiderin lipid laden macrophages,

Front 10

fibrous dysplasia

Back 10

mono-poly ostotic