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15 Cards in this Set

  • Front
  • Back
Cholecalciferol & Ergocalciferol Action/MOA
Regulates gene transcrip via Vit D receptor to increase Ca2+ & phosphate absorption
Intestine: Induces new protein synth, modulates Ca2+ flux

Bone: induces RANKL in osteoblasts & protein osteocalcin to reg mineralization

Decreases PTH!
Calcitrol
Bisphosphonates
The DRONATES!!

Alendronate
Risedronate
Ibendronate
Action of the DRONATES! (bisphosphonates)
Suppress osteoclasts and inhibits bone resportion;

Prevent dissolution of hydroxyapatite crystals!!
MOA for DRONATES (bisphosphonates)
Act on osteoclasts. They bind directly to hydroxyapatite crystals, preventing their dissolution.

Aminos: block farnesyl pyrophosphate synthase--> stops func of osteoclasts
Drugs used for Paget's dz
Dronates; Calcitonin
Bone drug PTH analog
Teriparatide
Teriparatide MOA
Acts on osteoblast to induce RANKL--> increase activity and # of osteoclasts!
Teriparatide Action
Pulsatile: increase bone formation

Continuous: increase resorption

Stim 1,25(OH)2D
Calcitonin Action/MOA
TONES down Ca2+ & phophate by binding receptors on osteoclasts--> inhibits bone resorption; Kindey: reduces reabsorption
The Selective Estrogen Receptor modulator used in bone dz
Raloxifene
Raloxifene Action/MOA
Selectively binds to E receptors--> inhibits resorption and turnover
Cinacalcet Action/MOA
Blocks PTH secretion by activating CaR
Sevelamer Action/MOA
Binds intestinal Phosphate
Denosumab Action/MOA
Binds and blocks receptor activator on RANKL--> inhibits osteoclast formation, maintenance, and survival--> decreases bone resorption and turnover