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15 Cards in this Set
- Front
- Back
Cholecalciferol & Ergocalciferol Action/MOA
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Regulates gene transcrip via Vit D receptor to increase Ca2+ & phosphate absorption
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Intestine: Induces new protein synth, modulates Ca2+ flux
Bone: induces RANKL in osteoblasts & protein osteocalcin to reg mineralization Decreases PTH! |
Calcitrol
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Bisphosphonates
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The DRONATES!!
Alendronate Risedronate Ibendronate |
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Action of the DRONATES! (bisphosphonates)
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Suppress osteoclasts and inhibits bone resportion;
Prevent dissolution of hydroxyapatite crystals!! |
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MOA for DRONATES (bisphosphonates)
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Act on osteoclasts. They bind directly to hydroxyapatite crystals, preventing their dissolution.
Aminos: block farnesyl pyrophosphate synthase--> stops func of osteoclasts |
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Drugs used for Paget's dz
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Dronates; Calcitonin
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Bone drug PTH analog
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Teriparatide
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Teriparatide MOA
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Acts on osteoblast to induce RANKL--> increase activity and # of osteoclasts!
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Teriparatide Action
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Pulsatile: increase bone formation
Continuous: increase resorption Stim 1,25(OH)2D |
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Calcitonin Action/MOA
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TONES down Ca2+ & phophate by binding receptors on osteoclasts--> inhibits bone resorption; Kindey: reduces reabsorption
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The Selective Estrogen Receptor modulator used in bone dz
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Raloxifene
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Raloxifene Action/MOA
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Selectively binds to E receptors--> inhibits resorption and turnover
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Cinacalcet Action/MOA
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Blocks PTH secretion by activating CaR
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Sevelamer Action/MOA
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Binds intestinal Phosphate
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Denosumab Action/MOA
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Binds and blocks receptor activator on RANKL--> inhibits osteoclast formation, maintenance, and survival--> decreases bone resorption and turnover
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