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27 Cards in this Set

  • Front
  • Back
what do diuretics cause?
decrease in blood volume, decrease in CO, decrease in MAP but chronic uses can result in increase in renin release-this also goes for the vasodilators.
what do beta blockers do?
they cause decrease in HR, decrease in stroke volume, and decrease in CO but chronic uses will result in no change in CO
What do Alpha antagonist cause?
They cause postural hypotension
what are the MOA for alpha antagonists?
decrease in MA, decrease in CO, decrease in venous return, decrease in TPR will trigger inrease in HR and TPR
what makes up the combined antagonists
labetolol and carvedilol
what is one important fact about carvedilol
it has significant anti-oxidant properties
what are main facts about alpha 2 agonists
it couples to GI and decrease in camp, inhibit Calcium influx, decrease in CO and arterial resistance, retention of NA and water
What do Imidazolidines do?
They produce sedation to some degree which can lead to withdrawal syndrome with BP rising above
What is agmatine
endogenous substance for alpha 1 and alpha 2 rcs. alpha 1 control BP
what is rilmanidine
preferential for alpha 1 versus alpha 2
What is imidozolidines tx
opiate withdrawal and as an adjunct pre-op to increase sedation
What do Guanadrel and Guanethidine do?
They do not enter the CNS, enters the sympathetic nerves by neuronal uptake. , decrease in CO/TPR
What does reserpine do
sedation and depression
What does arterial vasodilators and alpha 2 antagonist do
cause fluid retention and SNS reflex tachycardia
What has effects greater standing than supine and causes a decrease in venous return
Mixed vasodilators and non-selective alpha antagonists
What can cause pulmonary hypertension
Arterial vasodilators
What happens when you have a left ventricular compromised?
decreased arterial resistance, heart is not pumping enough blood to the tissues, as a result going to increase cO b/c of decrease in arterial resistance.
What does Hydralazine cause
release of NO from endothelial cells, dilates the arterioles-produces less postural hypotension,causes membrane hyperpolarization, decreasing Calcium entry.
What does hydralazine do
aggravate MI, causes headache, drug-induced lupus-like syndrome
What produces arterial/venous dilation
sodium nitroprusside
What does sodium nitroprusside do
causes toxicity with long term adminsitration which can lead to cyanide toxicity, hypertensive emergencies.
What does Fenoldopam do
tx of hypertensive crisis
What do Calcium channel blocker do
cause an increase in venous return, decreased arterial resistance
What do Dihydropuridines do
more vasc selective, prone to produce reflex tachycardia, two forms QR and SR
SR causes a decrease in HR/force-less risk, while QR causes reflex tachycardia.
What does verapamil do
causes a negative inotropic/chronotropic effects and ppt failure in pts with left ventricular dysfunction
What do ACE inhibitors do
causes a decrease in arteriolar resistance and increase in NA/water excretion, reduces sympathetic outflow..
what are the toxicities involved with ACE inhibitors
Angioneurotic edema
acute renal flow