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6 Cards in this Set
- Front
- Back
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Central tolerance for our own cells is established where?
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In the thymus. Negative selection process 'deletes' any T-cells that may react with 'self' HLA molecules
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What happens to T-cell lymphocytes that are specific for 'self' antigens?
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They are deleted or rendered non-reactive (anergy).
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Peripheral Tolerance (mechanism 1) is keyed by...
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...the presentation without B7-leads to T-cell anergy
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Peripheral Tolerance (Mechanism 2)
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B-cells encounter an enormous amount of self-antigen & induce apoptosis
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Peripheral Tolerance (Mechanism 3)
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Suppression of immune response by Ts-cells
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Auto-immune Response
Factors involved/reasons: |
Failure of clonal ablation
Genetic predisposition Polyclonal B-cell activation Th/Ts cell imbalance Hormonal Factors Immunologic cross reactivity Aging Defect in idiotypic-suppression network Alteration of tolerance by infections and inflammation |
