Bocock Uworld Week 5.4

Front 1

Causes of acute pancreatitis?

Back 1

"GETSMASHED"
gallstones, ethanol, trauma, steroids, mumps, autoimmune disease, scorpion sting, hypercalcemia/hypertriglyceridemia, endoscopic retrograde cholangiopancreatography, drugs (sulfa)

Front 2

Enzyme that converts all proteolytic pancreatic enzymes to their active forms?

Back 2

trypsin

Front 3

Bartonella henselae can cause this disease in immunocompromised pts?

Back 3

bacillary angiomatosis

Note: cat scratch disease in normal pts

Front 4

First line therapy for acute gout?

Back 4

NSAIDS (COX inhibitors)

Front 5

What is the rx for a patient with garlic breath?

Back 5

dimercaprol

Front 6

This toxin travels within the motor neuron by retrograde transport to the spinal cord?

Back 6

tetanus from clostridium tetani

Front 7

Associated with high doses of SSRIs?

Back 7

serotonin syndrome

Front 8

What is the precursor AA of serotonin?

Back 8

tryptophan

Front 9

Serotonin receptor antagonist used in the rx of serotonin syndrome?

Back 9

cyproheptadine

Front 10

The onset of action of an inhalational anesthetic is dependant on what parameter?

Back 10

the drug's solubility in the blood

note: the blood/gas partition coefficient

Front 11

An inhalational anesthetic with a HIGH blood/gas partition coefficient has a slow of fast onset of action?

Back 11

slow onset of action

Front 12

Papules w/ a sandpaper texture on chronically sun exposed areas of the skin?

Back 12

actinic keratosis

Front 13

CA associated with abnormal proliferations of cytotrophoblasts and syncytiotrophoblasts?

Back 13

Choriocarcinoma

Front 14

What happens when Abs attach to the capsule of S. Pneumo?

Back 14

the capsule swells

Note: this is the "quellung reactions"

Front 15

Acanthosis nigricans is commonly associated with what conditions?

Back 15

insulin resistance

underlying GI malignancies

Front 16

68 YO female w/ sudden blindness and jaw pain during a meal?

Back 16

temporal arteritis

Front 17

Test that should be performed if temporal arteritis is suspected?

Back 17

ESR

Front 18

Deletion of the long arm of what cromosome is associated w/ digeorge syndrome?

Back 18

long arm of chromosome 22

Front 19

Arterial wall is composed of what three layers?

Back 19

endothelial intima

smooth muscle media

connective tissue adventicia

Front 20

How are the vasculidities divided?

Back 20

Large vessel--> include the aorta and its branches

medium vessel--> include muscular arteries that supply organs

small vessel--> includes arterioles, capillaries, and venules

Front 21

Presents w/ HA, blindness, and jaw pain w/ an elevated ESR in female pt > 50 YO?

Back 21

temporal (giant cell) arteritis

Front 22

What is the tx for temporal (giant cell) arteritis?

Back 22

corticosteroids


note: high risk of blindness if no rx

Front 23

Presents in young asian females w/ visual and neurologic sxs w/ absent pulses..."pulseless disease"

Back 23

takayasu arteritis

Front 24

Granulomatous vasulitis that involves the aortic arch at branch points?

Back 24

takayasu arteritis

Front 25

Granulomatous vasulitis that involves branches of the carotid artery?

Back 25

temporal (giant cell) arteritis

note: involves temporal and opthalmic arteries

Front 26

Name the two conditions that are large vessel vasulitidies?

Back 26

temporal (giant cell) arteritis

takayasu arteritis

Front 27

In polyarteritis nodosum, you can have involvement of any organ except this one?

Back 27

the lung

Front 28

What is often found in the serum of pts w/ polyarteritis nodosum?

Back 28

HBsAg

Front 29

Early lesions consist of transmural inflammation with fibrinoid necrosis which heal w/ fibrosis producing a "string of pearls" on imaging?

Back 29

polyarteritis nodosum

Front 30

Name the medium vessel vasculidities that involve muscular arteries that supply organs?

Back 30

polyarteritis nodosum

Kawasaki disease

Buerger disease

Front 31

What vessels are involved in kawasaki disease that effects asian kids <4YO?

Back 31

coronary arteries

Front 32

Even though kawasaki disease presents with flu like sxs, what is the rx?

Back 32

ASA

Front 33

Necrotizing vasulitis involving the digits that leads to auto-amputation of fingers and toes?

Back 33

Buerger disease

Front 34

What risk factor is highly associated w/ Buerger disease where you have autoamputation of fingers and toes?

Back 34

Smoking

Front 35

Name the small vessel vaculidities that involve arterioles, capillaries, and venules?

Back 35

wegener granulomatosis

microscopic polyangitis

churg straus syndrome

Henoch schonlein purpura

Front 36

We"c"ener granulomatosis involves a necrotizing granulomatous vasculitis that involves what areas?

Back 36

nasopharynx, lungs, and kidneys

Front 37

What ab is associated w/ wegener granulomatosis that correlates w/ disease activity?

Back 37

c-anca

Front 38

What is the rx for wegener granulomatosis?

Back 38

cyclophosphamide

Front 39

Small vessel vasculitis that involves the lungs and kidneys and is associated with p-anca?

Back 39

microscopic polyangitis

Front 40

What is present in wegener granulomatosis that is not present in microscopic polyangitis?

Back 40

granulomas, nasophrynx involvement, and c-anca

Front 41

What two small vessel vasulitidies are associated with p-anca?

Back 41

microscopic polyangitis

churg strauss syndrome

Front 42

What features of churg strauss syndrome seperate it from microscopic polyangitis?

Back 42

granulomas, hx of asthma, and peripheral eosinophila

note: both have p-anca

Front 43

MC vasculitis in kids that is due to IgA immune complex depostion?

Back 43

henoch schonlein purpura

Front 44

Presents w/ PALPABLE purpura on ass and legs, and hematuria from IgA nephropathy following an URT infection?

Back 44

henoch schonlein purpura

Front 45

Causes of renal artery stenosis that can cause secondary HTN?

Back 45

elderly males->atherosclerosis

young females--> fibromuscular dysplasia

Front 46

Developmental defect in BV walls that results in thickening..especially in the renal artery in young females

Back 46

fibromuscular dysplasia

Front 47

4 modifiable risk factors for atherosclerosis?

Back 47

HTN, hypercholesterolemia, smoking, and diabetes

Front 48

Hyaline arteriolosclerosis is a consequence of what two things?

Back 48

benign HTN and diabetes

note: proteins leak into the vessel wall

Front 49

Arteriolosclerosis is divided into what two types?

Back 49

hyaline arteriolosclerosis-->B9 HTN and diabetes

hyperplastic arteriolosclerosis-->consequence of malignant HTN

Front 50

Thickening of a large or medium vessel wall w/ an intimal plaque?

Back 50

atherosclerosis

Front 51

Thickening of arteriole vessel walls?

Back 51

arteriolosclerosis

note: divided into hyaline and hyperplastic

Front 52

Thickening of arteriolar vessel walls due to hyperplasia of SM that is caused by malignant HTN?

Back 52

hyperplastic arteriolosclerosis

Front 53

Calcification of the media of medium sized vessels and this condition is non-obstructive?

Back 53

monkeberg medial calcific sclerosis

Front 54

Intimal tear w/ a dissection of blood through the media of the aortic wall?

Back 54

aortic dissection

Front 55

MCC of aortic dissection?

Back 55

HTN

note: marfans and ehlers danlos can also cause an AD

Front 56

Sharp tearing chest pain that radiates to the back?

Back 56

aortic dissection

Front 57

What is the classical way to get weakening of the aortic wall in a thoracic aneurysm?

Back 57

tertiary syphilis

note: results in a "tree back" apperance of the aorta

Front 58

What do you associate anti-mitochondrial abs with?

Back 58

primary biliary sclerosis

Front 59

Major complication of a thoracic anuerysm caused by tertiary syphilis?

Back 59

dilation of the aortic valve root which results in aortic valve insufficiency

Front 60

Ballon like dilation of the aorta that occurs BELOW the renal arteries but ABOVE the aortic bifurcation?

Back 60

AAA

Front 61

An AAA is classically due to the formation of this condition that leads to weakness of the aorta wall?

Back 61

atherosclerosis

Front 62

Presents w/ a pulsatile abdominal mass that grows w/ time in male smokers w/ HTN?

Back 62

AAA

Front 63

B9 tumor of BVs that often regresses during childhood?

Back 63

hemangioma

Front 64

Common locations of benign hemangiomas?

Back 64

liver and skin

Front 65

Malignant proliferation of endothelial cells?

Back 65

angiosarcoma

Front 66

Type of vascular CA associated w/ exposure to polyvinyl chloride?

Back 66

liver angiosarcoma

Front 67

Malignant proliferation of endothelial cells associated with HHV8?

Back 67

kaposi sarcoma

Front 68

HHV8 infection of endothelial cells creating purple plaques seen in older eastern european males, AIDS pts, and transfusion pts?

Back 68

kaposi sarcoma