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48 Cards in this Set
- Front
- Back
What are the Igs associated with warm and cold agglutinin?
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Warm--> IgG
Cold--> IgM |
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What are two protozoal diseases that can cause hemolytic anemia?
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(1) malaria
(2) babesiosis |
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In what hemotological disorder would you find a positive osmotic fragility test?
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hereditary spherocytosis
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What drug can be used to rx sickle cell disease?
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hydroxyurea-->creates HbF
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These inclusions are seen in erythrocytes in pts that do not have a functional spleen?
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howell jolly bodies
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Mneumonic for the conditions that cause basophilic stippling?
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"TAIL"
(1) thalessemias (2) anemia of chronic disease (3) iron deficiency (4) lead poisoning |
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Anemia resulting from mechanical destruction of erythrocytes due to aortic stenosis or prosthetic heart valves?
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macroangiopathic anemia
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Inhibit ADP induced expression of GPIIb/IIIa receptors on platelets by blocking ADP receptors?
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clopidogrel and ticlopidine
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What is the causes of ITP?
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Abs to GPIIb/IIa receptors on platelets
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What is the defect in Bernard Soulier diease?
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deficiency in the GPIb receptor (Plts cannot bind to collagen)
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Expressed on the surface of a plt after it is activated by ADP?
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GP IIb/IIIa
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This drug releases VWF stored in the endothelium and is used in the rx for VW's disease?
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DDVAP(desmopressin)
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mneumonic for the causes of DIC?
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"STOP Making New Thrombi"
(1) sepsis (2) trauma (3)obstetric complications (4)pancreatitis (5) malignancy (6)nephrotic syndrome (7)transfusions |
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MC lymphoma in the US and MC adult NHL?
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diffuse large B cell lymphoma
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Reed sternberg cells-owl's eyes?
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hodgkin lymphoma
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Lymphomas associated with epstein barr virus?
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(1) hodgkin lymphoma
(2) burkitt lymphoma |
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Lymphoma associated with long term celiac disease?
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intestinal T cell lymphoma
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The lymphoma equivalent of CLL?
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small lymphocytic lymphoma
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"Starry sky pattern" due to phagocytosis of apoptotic tumor cells?
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burkitt lymphoma
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hematologic disease associated with sjogren syndrome, hashimoto thyroiditis, and H. pylori?
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marginal celll MALToma (MALT lymphoma)
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What does it mean that prokaryotic mRNA is polycistronic?
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one mRNA codes for several proteins...ex; lac operon
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The lac operon codes for one mRNA that can code for three proteins. What 3 proteins are made?
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(1) beta-galactosidase
(2) beta-galactosidase permease (3) beta-galactosidase transacetylase |
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In response to vascular injury, what is responsible for intimal thickening and collagen deposition?
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smooth muscle cells that migrate from the media into the intima
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Can a competent pt refuse knowledge of their own diagnosis?
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yes...but a surrogate decision maker should be found so that rx can continue
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Type of study that collects data from a group of people to access frequency of disease at a particular "snap shot" point in time?
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cross sectional study
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Type of study that looks to see if exposure increases the likelihood of disease?
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cohort study
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How can you accentuate an S3 heart sound associated with LV heart failure?
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Place the pt in the left lateral decubitus position and have them fully exhale
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Class of drug that reverses vagally-mediated bronchoconstriction in asthma?
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antimusarinic agents like ipratropium
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Class of drug that causes bronchodilation by decreasing phosphodiesterase activity...therby increasing intracellular camp?
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methylxanthines (theophylline)
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Injury to the long thoracic nerve causes what two distinct sxs?
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(1) inability to abduct the shoulder past 90 degrees
(2) winging of the scapula |
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Common causes of injury to the long thoracic nerve?
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mastectomy
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What muscle is paralyzed when there is winging of the scapula from damage to the long thoracic nerve?
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serratus anterior muscle
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A reduction in bile flow (cholestasis) causes intestinal malabsorption and deficiencies in what vitamins?
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fat soluble vitamins (KADE)
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Characterized by disordered mineralization of newly formed bone matrix-associated with vit D deficiency in adults?
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osteomalacia
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Usually positive in patients with rheumatoid arthritis?
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rheumatoid factor (IgM against IgG)
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Causes erythema infectiosum (fifth disease) in children and arthritis in adults?
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parvovirus B19
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Constrast parvovirus arthritis and rheumatoid arthritis?
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parvovirus arthritis is self resolving
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Gene silencing in Huntington Disease occurs via this mechanism?
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histone methylation
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What are the seronegative spondyloartropathies associated with HLA B27?
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"PAIR"
(1) psoriatic arthritis (2)ankylosing spondylitis (3)IBD w/ arthritis (4) reactive arthritis |
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What are the HLA class I antigens?
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HLA-A, HLA-B, and HLA-C
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What are the HLA class II antigens?
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HLA-DR, HLA-DP, HLA-DQ
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LH stimulates what cells of the follicle to produce androgens?
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theca interna cells
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Aromatase converts androgens to estradiol under FSH stimulation within these cells of the follicle?
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granulosa cells
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This substance is found within egg whites and excess amounts can cause biotin deficiency?
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avidin
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How does lecithinase toxin from C. perferingens exert its effect?
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it splits plasma membranes
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Mostly occurs in children and presents with vague sxs of fever, malaise, and pain in the long bones?
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hematogenous osteomyelitis
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MCC of hematogenous osteomyelitis in children?
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staph aureus
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What sx of graves disease is not effected by beta blocker therapy?
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exophthalmos
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