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48 Cards in this Set

  • Front
  • Back
What are the Igs associated with warm and cold agglutinin?
Warm--> IgG

Cold--> IgM
What are two protozoal diseases that can cause hemolytic anemia?
(1) malaria
(2) babesiosis
In what hemotological disorder would you find a positive osmotic fragility test?
hereditary spherocytosis
What drug can be used to rx sickle cell disease?
hydroxyurea-->creates HbF
These inclusions are seen in erythrocytes in pts that do not have a functional spleen?
howell jolly bodies
Mneumonic for the conditions that cause basophilic stippling?
"TAIL"
(1) thalessemias
(2) anemia of chronic disease
(3) iron deficiency
(4) lead poisoning
Anemia resulting from mechanical destruction of erythrocytes due to aortic stenosis or prosthetic heart valves?
macroangiopathic anemia
Inhibit ADP induced expression of GPIIb/IIIa receptors on platelets by blocking ADP receptors?
clopidogrel and ticlopidine
What is the causes of ITP?
Abs to GPIIb/IIa receptors on platelets
What is the defect in Bernard Soulier diease?
deficiency in the GPIb receptor (Plts cannot bind to collagen)
Expressed on the surface of a plt after it is activated by ADP?
GP IIb/IIIa
This drug releases VWF stored in the endothelium and is used in the rx for VW's disease?
DDVAP(desmopressin)
mneumonic for the causes of DIC?
"STOP Making New Thrombi"
(1) sepsis
(2) trauma
(3)obstetric complications
(4)pancreatitis
(5) malignancy
(6)nephrotic syndrome
(7)transfusions
MC lymphoma in the US and MC adult NHL?
diffuse large B cell lymphoma
Reed sternberg cells-owl's eyes?
hodgkin lymphoma
Lymphomas associated with epstein barr virus?
(1) hodgkin lymphoma
(2) burkitt lymphoma
Lymphoma associated with long term celiac disease?
intestinal T cell lymphoma
The lymphoma equivalent of CLL?
small lymphocytic lymphoma
"Starry sky pattern" due to phagocytosis of apoptotic tumor cells?
burkitt lymphoma
hematologic disease associated with sjogren syndrome, hashimoto thyroiditis, and H. pylori?
marginal celll MALToma (MALT lymphoma)
What does it mean that prokaryotic mRNA is polycistronic?
one mRNA codes for several proteins...ex; lac operon
The lac operon codes for one mRNA that can code for three proteins. What 3 proteins are made?
(1) beta-galactosidase
(2) beta-galactosidase permease
(3) beta-galactosidase transacetylase
In response to vascular injury, what is responsible for intimal thickening and collagen deposition?
smooth muscle cells that migrate from the media into the intima
Can a competent pt refuse knowledge of their own diagnosis?
yes...but a surrogate decision maker should be found so that rx can continue
Type of study that collects data from a group of people to access frequency of disease at a particular "snap shot" point in time?
cross sectional study
Type of study that looks to see if exposure increases the likelihood of disease?
cohort study
How can you accentuate an S3 heart sound associated with LV heart failure?
Place the pt in the left lateral decubitus position and have them fully exhale
Class of drug that reverses vagally-mediated bronchoconstriction in asthma?
antimusarinic agents like ipratropium
Class of drug that causes bronchodilation by decreasing phosphodiesterase activity...therby increasing intracellular camp?
methylxanthines (theophylline)
Injury to the long thoracic nerve causes what two distinct sxs?
(1) inability to abduct the shoulder past 90 degrees
(2) winging of the scapula
Common causes of injury to the long thoracic nerve?
mastectomy
What muscle is paralyzed when there is winging of the scapula from damage to the long thoracic nerve?
serratus anterior muscle
A reduction in bile flow (cholestasis) causes intestinal malabsorption and deficiencies in what vitamins?
fat soluble vitamins (KADE)
Characterized by disordered mineralization of newly formed bone matrix-associated with vit D deficiency in adults?
osteomalacia
Usually positive in patients with rheumatoid arthritis?
rheumatoid factor (IgM against IgG)
Causes erythema infectiosum (fifth disease) in children and arthritis in adults?
parvovirus B19
Constrast parvovirus arthritis and rheumatoid arthritis?
parvovirus arthritis is self resolving
Gene silencing in Huntington Disease occurs via this mechanism?
histone methylation
What are the seronegative spondyloartropathies associated with HLA B27?
"PAIR"
(1) psoriatic arthritis
(2)ankylosing spondylitis
(3)IBD w/ arthritis
(4) reactive arthritis
What are the HLA class I antigens?
HLA-A, HLA-B, and HLA-C
What are the HLA class II antigens?
HLA-DR, HLA-DP, HLA-DQ
LH stimulates what cells of the follicle to produce androgens?
theca interna cells
Aromatase converts androgens to estradiol under FSH stimulation within these cells of the follicle?
granulosa cells
This substance is found within egg whites and excess amounts can cause biotin deficiency?
avidin
How does lecithinase toxin from C. perferingens exert its effect?
it splits plasma membranes
Mostly occurs in children and presents with vague sxs of fever, malaise, and pain in the long bones?
hematogenous osteomyelitis
MCC of hematogenous osteomyelitis in children?
staph aureus
What sx of graves disease is not effected by beta blocker therapy?
exophthalmos