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16 Cards in this Set
- Front
- Back
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what is herceptin
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monoclonal antibody that binds to the Her2/neu on cell surface promoting ADCC of the tumor cells
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pseudomonas toxin can be bound to CD22 on the surface of what kind of cancer cells to induce remission in 2/3 of patients
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hairy cell leukemia
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What are the (5) ways monoclonal antibodies can be used to treat cancer?
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monoclonal antibody to cell surface receptor inducing ADCC, toxin-labeled antibodies, drugs attached to antibodies, pro-drugs attached to antibodies (ADEPT), radio-labeled antibodies
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what are examples of drugs attached to antibodies
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adriamycin and doxorubicin
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what are heat shock proteins
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proteins whose synthesis is increased after cell is exposed to extreme heat, protect against harmful effects of high temp
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when tumor cells are extracted and added to a bacterial adjuvant, can they be used as an effective vaccine?
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no; but tumor cell + heat shock proteins are promising
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without B7 on tumor cells, what is the T cell response
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anergy
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do all cells need to be transfected with B7 to trigger T cell killing?
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no - once the CD8 cells have been activated B7 is no longer needed for killing, can kill B7 negative cells
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what is the concept of GM-CSF transfection
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infecting cells to express GM-CSF would cause recruitment of dendritic cells that will present tumor antigens to T cells
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how is GM-CSF paracrine-like in its action
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the GM-CSF is produced by one cell (the tumor cell) and it affects another cell (the dendritic cell)
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what does ISCOM stand for
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immune stimulatory complex
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how can ISCOMs stimulate the immune system against a tumor
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an ISCOM or micelle is used to transmit antigen particles into the APCs which then can be presented to T cells as any other cytoplasmic antigen
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peripheral blood mononuclear cells (monocytes, lymphocytes and NK cells) can be stimulated in vitro with what cytokine?
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IL-2
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the activated mononuclear cells created in vitro that can than be injected into the patient to treat cancer are called what
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lymphokin-activated killers (LAKs)
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performing the same process on cells from the patient's tumor creates what kind of cells
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lymphokin-activated tumor infiltrating lymphocytes (TILs)
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in a recent study, lentivirus was used to modify the TCR of a patients T cells so it would recognize what?
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CD19 (associated with B cells, so used to treat CLL)
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