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83 Cards in this Set
- Front
- Back
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Prednisone toxicity
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Cushing like symptoms
immunosuppression catarats acne osteoporosis hypertension peptic ulcers hyperglycemia psychosis insomnia |
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Microtubule interference
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mebendazole
griseofulvin cholchicine vincristine vinblastine |
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Nephrotoxic and ototoxic
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cisplatin, carboplatin
loop diuretics aminoglycosides vancomycin |
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Forms a complex between topoisomerase II and DNA
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etopside
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Alkylates DNA, toxicity --> pulmonary fibrosis
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busulfan
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Fragments DNA, toxicity --> pulmonary fibrosis
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bleomycin
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Blocks purine synthesis, metabolized by xanthine oxidase
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6 mercaptopurine
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Cross links DNA, nephrotoxic, ototoxic
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cisplatin, carboplatin
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Nitrogen mustard, alkylates DNA (electrophil that binds DNA)
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cyclophosphamide
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Folic acid analog that inhibits dihydrofolate reductase
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methotrexate
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Prednisone toxicity
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Cushing like symptoms
immunosuppression catarats acne osteoporosis hypertension peptic ulcers hyperglycemia psychosis insomnia |
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Microtubule interference
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mebendazole
griseofulvin cholchicine vincristine vinblastine |
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Nephrotoxic and ototoxic
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cisplatin, carboplatin
loop diuretics aminoglycosides vancomycin |
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Forms a complex between topoisomerase II and DNA
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etopside
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Alkylates DNA, toxicity --> pulmonary fibrosis
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busulfan
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Fragments DNA, toxicity --> pulmonary fibrosis
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bleomycin
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Blocks purine synthesis, metabolized by xanthine oxidase
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6 mercaptopurine
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Cross links DNA, nephrotoxic, ototoxic
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cisplatin, carboplatin
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Nitrogen mustard, alkylates DNA (electrophil that binds DNA)
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cyclophosphamide
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Folic acid analog that inhibits dihydrofolate reductase
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methotrexate
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Prevents tubulin disasembly
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paclitaxel
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Intercalates DNA, produces oxygen free radicals, cardiotoxic
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Doxorubicin, daunorubicin
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DNA aklylating agents used in brain cancer
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Nitrosureas (-mustine)
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Prevents tubulin assembly
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vincristine, vinblastine
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Inhibits thymidylate synthase--> dec nucleoside synthesis
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5 FU
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SERM blocks estrogen binding to ER (+) cells
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tamoxifene, raloxifene
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Mechanism similar to antivirals, acyclovir and foscarnet
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cytarabine
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mechanism similar to fluroquinolones
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etopside
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Mechanism similar to trimethoprim
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Methotrexate
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Monoclonal antibody against HER 2 (erb B2)
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Trastuzumab
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Free radical induced DNA strand breakage
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bleomycin, doxorubicin, daunorubicin
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Inhibitor of PRPP synthase
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6 mercaptopurine
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Reversible with leucovorin
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methotrexate
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Treatment for choriocarcinoma
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vincristine, vinblastine, methotrextate
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Treatment for AML
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cytarabine
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Treatment for CML
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busulfan, imatinib
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Prevents breast cancer
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tamoxifene, raloxifene
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Applied topically for AKs and basal cell cancers
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5 FU
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Treatment for childhood tumors (Ewigs sarcoma, Wilms tumor, rhabdomyosarcoma)
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Dactinomycin
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Inhibits ribonucleotide reductase
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Hydroxyurea
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SE of hemorrhagic cystitis
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Cyclophosphamide, ifofamide
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Antibody against Philadelphia chromosome
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Imatinib
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Atropine like side effects (anticholinergic side effects)
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TCAs, low potency neuroleptics, 1st generation antihistamines, amantadine
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Coronary vasospasm
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Cocaine, sumatriptan, amphetamines, ergotamines
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Cutaneous flushing
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VANC: vancomycin, adenosine, niacin, Ca2+ channel blockers
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Dilated cardiomyopathy
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Doxorubicin, daunorubicin
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Torsades de pointes --> prolonged QT interval
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Class III (sotalol), class IA (quinidine) antiarrhythmics, maacrolides, haldol, risperidone, chloroquine, mefloquine, methodone, HIV protease inhibs
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Agranulocytosis
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Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
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Aplastic anemia
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Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
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Direct coombs-positive hemolytic anemia
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Methyldopa
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Gray baby syndrome
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Chloramphenicol
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Hemolysis of G6PD deficient patients
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Isoniazid (INH), sulfomamides, primaquine, aspirin, ibuprofen, nitrofurantioin, dapsone, napthelene, fava beans
hemolysis is a PAIN |
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Megaloblastic anemia
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Phenytoin, methotrexate, sulfa drugs (having a blast with PMS)
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Thrombotic complications
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OCPs esp in smokers >35 years of age or women with migraine w/ aura
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Thrombocytopenia
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heparin, H2 blcokers (cimetidine)
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Cough
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ACE inhibitors (no cough w/ ARBS)
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Pulmonary fibrosis
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BLeomycin, amidodarone, busulfan
(it's hard to BLAB when you have pulmonary fibrosis) |
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Acute cholestatic hepatitis
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Macrolides, erythromycin estolate
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Focal to massive hepatic necrosis
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Halothane, valproic acid, acetominophen, Amanita phalloides (mushrooms)
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Hepatitis
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INH
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Psuedomembranous colitis
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Clindamycin, ampicillin
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Adrenocortical insufficiency
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Glucocorticoid withdrawal (HPA suppression)
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Gynecomastia
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Spironolactone, digitalis, cimetidine, chronic alcohol use, estrogens, ketoconazole
(some drugs create awesome knockers) |
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Hot flashes
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Tamoxifen, clomiphene (SERMS)
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Hypothyroidism
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Lithium, amiodarone
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Gingival hyperplasia
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Phenytoin
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Gout
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Furosemide, heparin
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Osteoporosis
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Corticosteroids, heparin
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Photosensitivity
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Sulfonamides, amiodarone, tetracycline (SAT for a photo)
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Rash (Steven Johnson syndrome)
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Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin, allopurinol
(seizure, sulfur, - cillin) |
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SLE like syndrome
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Sulfonamides, hydralazine, INH, procainimide, phenytoin
(SHIPP) |
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Tendonitis, tendon rupture and cartilage damage (kids)
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Fluoroquinolones
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Fanconi's syndrome
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expired tetracycline (defect in PCT reabsorption)
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Interstitial nephritis
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Methicillin, NSAIDs, furosemide
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Hemorrhagic cystitis
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Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)
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Cinchonism
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Quinidine, quinine (dizziness, HA, tinnitus)
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Diabetes Insipidus
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Lithium, demeclocycline (nephrogenic)
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Parkinson like syndrome
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Haloperidol, chlopromazine, reserpine, metoclopramide, MPTP
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Seizures
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Buproprion, imipenem/cilatsin, isoniazid, prime rose oil, enflurane, benzos/etoh withdrawal
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Tardive dyskinesia
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Atypical Antipsychotics
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Disulfuram like reaction
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Metronidazole ,certain cephalosporins, procarbazine, 1st generation sulfonylureas, disulfiram
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Nephrotoxicity/neurotoxicity
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Polymyxins
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Nephrotoxicity/ototoxicity
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Amnioglycosides, vancomycin, loop diuretics, cisplatin
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