Boards: Pharm And Bug Notes From First Aid

Front 1

___ found in death cap mushrooms inhibits RNA polymerase II. Causes liver failure if ingested.

Back 1

Alpha-amanitin

Front 2

Patients with lupus make Antibodies to ______

Back 2

spliceosomal snRNPs

Front 3

____ inhibit formation of the initiation complex and cause misreading of mRNA.

Back 3

Aminoglycosides.

Front 4

____ is a drug that inhibits 50S peptidyltransferase.

Back 4

Chloramphenicol.

Front 5

____ binds 50S, blocking translocation.

Back 5

Macrolides and Clindamycin

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What do these drugs have in common? Mebendazole/thiabendazole, Griseofulvin, Vincristine/vinblastin, Paclitaxel, Colchicine

Back 6

Drugs that act on microtubules.

Front 7

Processes that use NADPH:

Back 7

1) anabolic processes, 2) respiratory burst, 3) P-450, 4) Glutathione reductase

Front 8

Cyclosporine

Back 8

prevents production of IL-2. Suppresses organ rejection; selected autoimmune disorders;
Nephrotoxic; predisposes pts to viral infections and lymphomas

Front 9

Tacrolimus

Back 9

binds to FK-binding proteins, inhibits secretion of IL-2; immunosuppression; toxicity: nephrotoxicity, PN, HTN, pleural effusion, hyperglycemia

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Azathioprine

Back 10

MOA: antimetabolite precursor of 6-mercaptopurine; Kidney transplantation and glomerulonephritis and hemolytic anemia; Tox: BM suppression--inc. by allopurinol

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Muromonab

Back 11

Monoclonal ab. that binds CD3 on surface Tcells. Use: Immunosupres. after kidney transplant; Tox: Hypersens. rxn,

Front 12

Sirolismus

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binds to mTOR, inhibits T-cell prolif response to IL-2; Use: after kidney transplantation, Tox: Hyperlipidemia, thrombocytopenia, leukopenia

Front 13

Mycophenolate mofetil

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Inhibits de novo guanine synthesis and blocks lymphocyte production

Front 14

Daclizumab

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Monoclonal antibody with high affinity for the IL-2 receptor on activated Tcells.

Front 15

cAMP inducers (bugs that do it)

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1) vibrio cholera toxin-- turns "on" on, 2) Pertussis toxin--turns "off" off, 3) E.coli (ETEC), 4) Bacillus anthracis (bacterial adenylate cyclase--INC cAMP)

Front 16

Streptococcus pneumoniae: MCC of....

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MOPS: Meningitis, Otitis Media, Pneumonia, Sinusitis

Front 17

____ Optocin sensitive

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MOPS are Most Optochin Sensitive (Streptococcus pneumoniae)

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____ Optocin resistant

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Viridans group streptococci. alpha-hemolytic--streptococcus mutans and s. sanguis (not afraid of the chin)

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Pus, empyema, abscess

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S. aureas

Front 20

Pediatric infection

Back 20

Haemophilus influenzae (including epiglottis)

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Pneumonia in cystic fibrosis, burn infection

Back 21

Pseudomonas aeruginosa

Front 22

Branching rods in oral infection, sulfur granules

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Actinomyces israelii

Front 23

Traumatic open wound

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Clostridium perfringens

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Surgical wound

Back 24

S. aureas

Front 25

Dog or cat bite

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Pasteurella multocida

Front 26

Currant jelly sputum

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Klebsiella

Front 27

Positive PAS stain

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Tropheryma whippelii (Whipple's Disease)

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Sepsis/meningitis in newborn

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Group B strep

Front 29

Health care provider

Back 29

HBV (from needle stick)

Front 30

Fungal infection in diabetic

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Mucor or Rhizopus spp.

Front 31

Asplenic pt.

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Encapsulated microbes, especially SHiN (S.pneumoniae, H.influenza type B, N. meningitidis)

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Chronic granulomatous disease

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Catalase positive microbes--S. aureas, Nocardia spp., Serratia marcescens, Pseudomonas cepacia, Aspergillus spp

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Neutropenic patients

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Candida albicans (systemic)

Front 34

Bilateral Bell's palsy

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Borrelia burgdorferi (Lyme disease)

Front 35

Drugs with MOA:
Block cell wall synthesis by inhibition of peptidoglycan cross-linking

Back 35

Penicillin, ampicillin, ticarcillin, piperacillin, imipenem, aztreonam, cephalosporins

Front 36

Drug MOA:
Block peptidoglycan synthesis

Back 36

Bacitracin, vancomycin

Front 37

Drug MOA:
Disrupt bacterial cell membranes

Back 37

Polymyxins

Front 38

Drug MOA: Block nucelotide synthesis

Back 38

Sulfonamides, trimethoprim

Front 39

Drug MOA: Block DNA topoisomerases

Back 39

fluoroquinolones

Front 40

Drug MOA: Block mRNA synthesis

Back 40

Rifampin

Front 41

Drug MOA: Block protein synthesis at 50S ribosomal subunit

Back 41

Chloramphenicol, macrolides, clindamycin, streptogramins (quinupristin, dalfopristin), linezolid

Front 42

Drug MOA: Block protein synthesis at 30S ribosomal subunit

Back 42

Aminoglycosides, tetracyclines

Front 43

Bacteriostatic Abx:

Back 43

Erythromycin, Clindamycin, Sulfamethoxazole, Trimethoprim, Tetracyclines Chloramphenicol (We're ECSTaTiC about bacteriostatics)

Front 44

Bactericidal Abx:

Back 44

Vancomycin, Fluoroquinolones, Penicillin, Aminoglycosides, Cephalosporins, Metronidazole ("Very Finely Proficient At Cell Murder")

Front 45

Aminoglycosides

Back 45

Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin. Tox: Nephrotoxicity, Ototoxicity, Teratogen.

Front 46

Tetracyclines

Back 46

Tetracycline, doxycycline, demeclocycline, minocycline.

Front 47

Macrolides

Back 47

Erythromycin, azithromycin, clarithromycin