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28 Cards in this Set
- Front
- Back
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Bruton's X-linked agammaglobulinemia
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B-cell pathology
tyrosine kinase mutation poorly developed germinal lymph centers absence of B-cells, plasma cells, IG affects males after 6 mo of age Assoc. w/ lymphoma, leukemia, myeloma |
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Isolated IgA deficiency
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B-cells do not differentiate into IgA secreting plasma cells
Most common inherited B-cell defect Increased mucosal surface infections |
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Common Variable Immunodeficiency
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Mature B-cells do not differentiate into plasma cells
Absence of various Ig isotypes Associated with hemolytic anemias and lymphoid tumors |
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Ataxia-Telangiectasia
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Affects B-cells
Defective DNA repair Decreased IgA levels Ataxia, Telangiectasia, graying hair, irregular pigmentation, increased infections / malignancies |
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DiGeorge's Syndrome
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Thymic Hypoplasia (thymus and parathyroids affected)
Absence of T cells Lip, ear, aortic arch abnormalities Defective development of 3rd and 4th arches Increased viral/fungal infections Decreased Type IV hypersensitivity PTH deficiency --> tetany from hypocalcemia Microdeletion of chrom 22 |
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Job's Syndrome
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T-helper cells don't produce INF-gamma
Elevated IgE Poor PMN chemotaxis Increased S. aureus infections |
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SCID
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Defective stem cell differentiation
X-linked and auto recessive Adenosine deaminase deficiency Absent lymphoid tissue Most severe; death before 2 y.o. |
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Wiskott-Aldrich syndrome
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Affects B and T cells
Defective IgM response to LPS Decreased IgM levels, elevated IgA levels, normal IgE X-linked Triad: infections, eczema, thrombocytopenia |
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IL-1
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Released by: monocytes, macrophages, PMNs, fibroblasts, epithelial cells, endothelial cells
Fever Stimulates T-helpers Stimulates Osteoclasts |
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IL-2
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Released by: T(H)1 cells
Stimulates T(H) and T(C) cells |
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IL-3
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AKA CSF
Released by: T(H) cells and NK cells Stimulates hematopoeitic stem cells |
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IL-4
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Released by: T(H)2 cells
Stimulates B cells and IgE |
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IL-5
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Rleased by: T(H)2 cells
Stimulates B-cells and IgA Stimulates eosinophils |
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IL-6
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Released by: monocytes, macrophages, fibroblasts, T(H) cells
Fever Stimulates B cells Stimulates T(H) cells |
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IL-8
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Released by: monocytes and macrophages
Chemotaxis |
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IL-10
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Released by: T(H)2 cells
Inhibits T(H)1 cells |
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IL-12
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Released by: monocytes and macrophages
Stimulates T(H)1 cells |
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INF-gamma
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Released by: T(H)1 cells
Stimulates monocytes, macrophages, NK cells, PMNs |
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TNF-alpha
TNF-beta |
Released by: monocytes, macrophages, T cells (beta)
Stimulates adhesion molecules Stimulates T(H) cells Stimulates osteoclasts Cachexia |
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TGF-beta
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Released by: monocytes, macrophages, T cells, B cells
The anti-cytokine Inhibits monocytes, macrophages, NK cells, PMNs, T-cells, B-cells Stimulates collagen formation/wound healing |
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histamine actions
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vasodilation
bronchoconstriction vascular permeability mediator of anaphylaxis |
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prostaglandin actions
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vasodilation
pain fever |
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leukotriene actions
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vasodilation
bronchoconstriction vascular permeability chemotaxis (LT-B4) asthma |
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serotonin actions
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vasoconstriction
no bronchial effect vascular permeability |
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bradykinin
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vasodilation
bronchodilation pain vascular permeability |
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nitric oxide actions
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vasodilation
tissue damage |
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complement protein actions
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vasodilation
bronchoconstriction vascular permeability (3a, 5a) chemotaxis |
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FMLP actions
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chemotaxis
derived from amino acids |
