Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
41 Cards in this Set
- Front
- Back
|
Catalase + bugs
|
Staph, Kleb, Aspergillus, Serratia
|
|
|
IL4
|
activates B cells
|
|
|
IFNg
|
activates Macs
|
|
|
Macs release what to activate T cells
|
IL1, IL6, TNFa
|
|
|
Costimulator molecules
|
T-CD28
B - B7 |
|
|
Adhesion molecules
|
LFA1, ICAM1, LFA3, CD2
|
|
|
B cell T cell interactions - stimulation
|
MHCII and TCR - activation
Costimulation - CD28/B7, IL2, IL4, IL5 Class switching CD40L/CD40 |
|
|
IL1 - macs
|
pyrogenic, stimulates IL2 secretion
|
|
|
IL2 - Th1, NK, Tc
|
stimulates B, T cell GF
|
|
|
IL3 - Tc
|
stimulates BM
|
|
|
IL4 - Th2, mast cells
|
Stim B cells, IgG and IgE
|
|
|
IL5 - Th2
|
B cell diff, Eosinophils, IgA
|
|
|
IL6 -
|
acute phase proteins, B cells
|
|
|
IL7
|
stimulates pres
|
|
|
IL8 - macs
|
chemotaxis and adhesion of neutrophikls
|
|
|
IL10
|
downregs CMI, inhibits cytokine release
|
|
|
IL12
|
NK cells, induces Th0 --> Th1, increases CD8 and delayed type hypersensitivity cells
|
|
|
TNFa - cytotoxic Tc, macs
|
increases MHCI expression, increases inflammation
|
|
|
TNFb - cytotoxic T cells
|
increases MHCI, increases inflammation
|
|
|
IFNg - Th1 cells
|
stims macs, NK
inh Th2 cells |
|
|
CD14
|
endotoxin receptor - marker for macs
|
|
|
essential step in CMI
|
Th1 activation via MHC class II molecule - must be specific
|
|
|
how do CD8s kill?
|
perforin - cell membrane puncture --> lysis
granzymes: damages cell cytokines: IFNg and TNFb --> induces cell to produce enzymes to lead to its own death (apoptosis) fas/fas ligand: induces apoptosis on targe cell (if has fas) |
|
|
how do NK cells kill?
|
just like CD8s
|
|
|
NK markers
|
CD16, CD56
|
|
|
NK-ADCC (ab dependent cellular cytotoxicity)
|
Fc receptors (CD16) on NK that recognize IgG
|
|
|
TNFb
|
depresses protein synthesis, causes production of ROS
|
|
|
classic pathway
|
activated by antigen-antibody complexes
|
|
|
alternative pathway
|
activated by pathogen surfaces
|
|
|
alternative pathway is to
|
extrinsic pathway of coagulation cascade (activated by damaged vessels)
|
|
|
classic pathway is to ..
|
intrinsic pathway of coagulation cascade (activated by collagen, prekalikren, hageman factor) -- inflammation?
|
|
|
complement functions
|
1. recruitment
2. opsonization 3. MAC attack 4. clearance of immune complexes |
|
|
anaphylatoxins
|
C3a, C5a, C4a
|
|
|
immune clearance and opsoinzation
|
C3b
|
|
|
C5a
|
chemotaxis
|
|
|
chemoattractants for eosinophils
|
histamine, C5a, ECF-A, leukotriene B4, Platelet activating factor
contains - histaminase, aryl sulfatase, MBP |
|
|
C3 deficiency
|
increased susceptibility to pyogenic infxns
|
|
|
C5-C8 deficiency
|
recurrent neisseria infxns
|
|
|
C1 inhibitor deficiency
|
hereditary angioedema
|
|
|
C2 deficiency
|
increased incidence of connective tissue disorders
|
|
|
C1, C4, C2 deficiency
|
leukocyte adhesion deficiency - opsonization not efficient
|
