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8 Cards in this Set
- Front
- Back
Fatty acid synthesis
Acetyl CoA is the substrate and palmitate is the end product |
Occurs mostly in the cytoplasm of liver cells
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Thin body type in Type 1 diabetes. Why?
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Lack of insulin results in ↓ acetyl CoA carboxylase activity-->less fatty acids + triglycerides are mase
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Essential fatty acids
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Linolenic and linoleic acid
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Quick review of DKA (ketogenesis)
Occurs in liver mitochondria High rate of fatty acid oxidation (triglyceride metabolism) Insulin normally inhibits hormone sensitive lipase The two big activators of hormone sensitive lipase are low insulin and epi EXCESSIVE hormone sensitive lipase activity-->TCA cycle becomes saturated with acetyl CoA-->ketone bodies |
x
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Functions of the eicosanoids derived from arachidonic acid:
Phospholipase A2 catalyzes the removal of arachidonic from membrane phospholipids: Prostaglandins Thromboxanes Leukotrienes |
VD, exudation, and pain
Platelet aggregation and VC POTENT bronchoconstriction |
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Niemann-pick
X sphingomyelinase (sphingo-pick) ↑sphingomyelin Severe MR, HSM, fatal early, cherry red macula |
x
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Gaucher's
X ß-glucosidase ↑ cereBROside MR, HSM, erosion of long bones/osteoporosis, Az Jews |
x
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Fabry's
X α-galactosidase ↑ Globoside Angiokeratomas, reddish-purple rash, kidney/heart failure |
X
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