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8 Cards in this Set

  • Front
  • Back
Fatty acid synthesis
Acetyl CoA is the substrate and palmitate is the end product
Occurs mostly in the cytoplasm of liver cells
Thin body type in Type 1 diabetes. Why?
Lack of insulin results in ↓ acetyl CoA carboxylase activity-->less fatty acids + triglycerides are mase
Essential fatty acids
Linolenic and linoleic acid
Quick review of DKA (ketogenesis)
Occurs in liver mitochondria
High rate of fatty acid oxidation (triglyceride metabolism)
Insulin normally inhibits hormone sensitive lipase
The two big activators of hormone sensitive lipase are low insulin and epi
EXCESSIVE hormone sensitive lipase activity-->TCA cycle becomes saturated with acetyl CoA-->ketone bodies
x
Functions of the eicosanoids derived from arachidonic acid:
Phospholipase A2 catalyzes the removal of arachidonic from membrane phospholipids:
Prostaglandins
Thromboxanes
Leukotrienes
VD, exudation, and pain
Platelet aggregation and VC
POTENT bronchoconstriction
Niemann-pick
X sphingomyelinase (sphingo-pick)
↑sphingomyelin
Severe MR, HSM, fatal early, cherry red macula
x
Gaucher's
X ß-glucosidase
↑ cereBROside
MR, HSM, erosion of long bones/osteoporosis, Az Jews
x
Fabry's
X α-galactosidase
↑ Globoside
Angiokeratomas, reddish-purple rash, kidney/heart failure
X