Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
105 Cards in this Set
- Front
- Back
glycoproteins=
|
immunoglobins
|
|
allergic to injected drug>
|
severe anaphylaxis
|
|
immediate txt
if conscious |
inject
epi>>>IM or subQ |
|
immediate txt
if unconscious |
inject
epi>>>IV |
|
epi opens
|
airway
raises BP |
|
reduce symptoms of anaphylatic shock
|
antihistamines
corticosteroid |
|
b cells
|
humoral immunity
|
|
most potent of anaphylatoxin
|
C5a
|
|
binding of complement due to interaxn with immune complexes
|
complement fixation
|
|
fix complement
|
IgM
IgG |
|
wassermann test
|
syphilis
*detect presence of specific antigen or antibody |
|
atopic allergies
|
atopic dermatitis
rhinitis allergic asthma |
|
type I hypersensitvity
|
atopic allergies
|
|
lower respiratory tract
|
allergic asthma
|
|
specific IgE antibodies
nonspecifif inhaled irritants> |
mast cell degranulation=
histamine leukotrienes |
|
eczema
|
atopic dermatitis
|
|
most common in infants
|
atopic dermatitis
|
|
itchy
|
atopic dermatitis
|
|
detection of antigen
|
immunofluorescence
|
|
blood typing
|
hemagglutination
|
|
antigen on surface of RBC and addition of antibody leads to clumping
|
hemagglutination
|
|
complement sys activated
|
1-classical complement
2-alternative complement |
|
complement system activated at
|
C1
C3 |
|
alternative pathway
|
activation of C3
|
|
major importance in host defense against bacterial infection
|
C3
|
|
activated by invading micro-o
doesnt require antibody |
antibody independent
C3=alternative pathway |
|
binding of specific part of antibody molecule to C1
|
Classical pathway
|
|
antibody dependent
|
classical
|
|
both pathways>
|
cell lysis
|
|
MAC
|
cytolysis
|
|
cytolysis
|
lysis of bacteria/cells
such as tumor RBC |
|
MAC derived from
|
complement activation
|
|
constituent of classical complent
|
C1
|
|
calcium required for activation
|
C1
|
|
kiddie antibodies disappear 6-12mos
|
passive immunity
|
|
occur naturally/artifically
|
acquired immunity
|
|
active or passive
|
acquired immunity
|
|
exposed to antigen
|
naturally active immunity
|
|
IgG passed from mom to fetus
|
naturally passive immunity
|
|
vaccination with killed inactivted attenuated bacteria/toxiod
|
artificial active immunity
|
|
injection of immune serum/gamma globulin
|
artificial passive immunity
|
|
slow onset
|
active immunity
|
|
resistance is long term
|
active immunity
|
|
immune response consists of
antibodies activated helper cytotoxic T lymphocytes |
active immunity
|
|
antibodies are preformed in another host
|
passive immunity
|
|
advantage:
immediate availability of antibodie |
passive immunity
|
|
disadvantage:
short duration |
passive immunity
|
|
react with antibodies by not antigenic
|
hapten
|
|
too small to elicit formation of antibodies
|
hapten
|
|
many drugs are hapten
|
pencillins
|
|
immunogens
|
antigens
|
|
antibody binding site on an antigen
|
epitope
|
|
not acquired thru contact with an antigen
|
natural immunity=
innate immunity |
|
re=exposure to a specific antigen
|
hypersensitivity
|
|
occurs after exposure to an antigen
|
acquired immunity
|
|
specific
improves upon repeated exposure |
acquired immunity
|
|
mediated by :
antibody T lymphocytes |
acquired immunity
|
|
long term memory
|
acquired immunity
|
|
specific
|
acquired immunity
|
|
nonspecific
|
natural immunity
|
|
does not improve after exposure to organism
|
natural immunity
|
|
no memory
|
natural immunity
|
|
does not arise from previous infection/vaccination
|
natural immunity
|
|
improves with repeated exposure
|
natural immunity
|
|
complement protein made in GI epi
|
C1
|
|
end product of activation of complement cascade
|
membrane attack complex
|
|
C5b
C6 C7 C8 C9 |
MAC
|
|
makes holes in membrane of gram -
RBC |
MAC
|
|
derived from unsaturated FA
|
leukotrienes
|
|
host defense
|
leukotrienes
|
|
role in inflammation and allergic rxn
|
leukotrienes
|
|
prostglandins
thromboxane |
cylooxygenation
|
|
leokotrienes
|
lipoxygenation
|
|
slow reacting substances of anaphylaxis
|
leukotrienes
|
|
LT 100-1,000X potent as
|
histamine
prostaglandins |
|
bronchioles
where there is allergen rxn |
asthma
|
|
pricipal symptoms of anaphylaxis
|
histamine
|
|
secretory immunoglobin
|
IgA
|
|
protect surface tissue
|
IgA
|
|
most prevalent humoral antibodies produced
|
IgA
|
|
type AB blood
|
A and B antigens
|
|
found in plasma of type O
|
antibodies
anti-A anti-B |
|
incorrectly cross match blood in transfusion
|
agglutination of donor's erythrocytes
|
|
universal recipients
|
type AB
|
|
universal donor
|
type O
|
|
binds to receptors on basophil/mast cells
|
type I
|
|
anaphylatic
|
type I
|
|
cytotoxic
|
type II
|
|
immune complex
|
type III
|
|
cell mediated
|
type III
|
|
hay fever
|
type 1
|
|
autoimmune hemolytic anemias
|
type 2
|
|
goodpastures
|
type 2
|
|
antibody dependent cellular cytotoxicity
|
type 2
|
|
cytotoxic antibodies
|
type 2
|
|
immune complex
|
type 3
|
|
autoimmune dx:
SLE RA |
type 3
|
|
cell mediated
delayed type hypersensitiviy |
type 4
|
|
granulomatous dx
|
type 4
|
|
cytotoxic antibodies :
IgG, IgM formed against cell surface antigens |
type 2
|
|
complement is involved
|
type 2
|
|
antibodies formed against exogenous/endogenous antigens
|
type 3
|
|
complement and leukocytes involved
|
type 3
|
|
mononuclear cells=
T lymphocytes macrophages |
type 4
|
|
interleukin and lymphokine production
|
type 4
|