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105 Cards in this Set

  • Front
  • Back
glycoproteins=
immunoglobins
allergic to injected drug>
severe anaphylaxis
immediate txt

if conscious
inject
epi>>>IM or subQ
immediate txt

if unconscious
inject

epi>>>IV
epi opens
airway
raises BP
reduce symptoms of anaphylatic shock
antihistamines
corticosteroid
b cells
humoral immunity
most potent of anaphylatoxin
C5a
binding of complement due to interaxn with immune complexes
complement fixation
fix complement
IgM
IgG
wassermann test
syphilis

*detect presence of specific antigen or antibody
atopic allergies
atopic dermatitis
rhinitis
allergic asthma
type I hypersensitvity
atopic allergies
lower respiratory tract
allergic asthma
specific IgE antibodies
nonspecifif inhaled irritants>
mast cell degranulation=
histamine
leukotrienes
eczema
atopic dermatitis
most common in infants
atopic dermatitis
itchy
atopic dermatitis
detection of antigen
immunofluorescence
blood typing
hemagglutination
antigen on surface of RBC and addition of antibody leads to clumping
hemagglutination
complement sys activated
1-classical complement

2-alternative complement
complement system activated at
C1
C3
alternative pathway
activation of C3
major importance in host defense against bacterial infection
C3
activated by invading micro-o
doesnt require antibody
antibody independent

C3=alternative pathway
binding of specific part of antibody molecule to C1
Classical pathway
antibody dependent
classical
both pathways>
cell lysis
MAC
cytolysis
cytolysis
lysis of bacteria/cells
such as

tumor
RBC
MAC derived from
complement activation
constituent of classical complent
C1
calcium required for activation
C1
kiddie antibodies disappear 6-12mos
passive immunity
occur naturally/artifically
acquired immunity
active or passive
acquired immunity
exposed to antigen
naturally active immunity
IgG passed from mom to fetus
naturally passive immunity
vaccination with killed inactivted attenuated bacteria/toxiod
artificial active immunity
injection of immune serum/gamma globulin
artificial passive immunity
slow onset
active immunity
resistance is long term
active immunity
immune response consists of
antibodies
activated helper
cytotoxic T lymphocytes
active immunity
antibodies are preformed in another host
passive immunity
advantage:
immediate availability of antibodie
passive immunity
disadvantage:
short duration
passive immunity
react with antibodies by not antigenic
hapten
too small to elicit formation of antibodies
hapten
many drugs are hapten
pencillins
immunogens
antigens
antibody binding site on an antigen
epitope
not acquired thru contact with an antigen
natural immunity=
innate immunity
re=exposure to a specific antigen
hypersensitivity
occurs after exposure to an antigen
acquired immunity
specific
improves upon repeated exposure
acquired immunity
mediated by :
antibody
T lymphocytes
acquired immunity
long term memory
acquired immunity
specific
acquired immunity
nonspecific
natural immunity
does not improve after exposure to organism
natural immunity
no memory
natural immunity
does not arise from previous infection/vaccination
natural immunity
improves with repeated exposure
natural immunity
complement protein made in GI epi
C1
end product of activation of complement cascade
membrane attack complex
C5b
C6
C7
C8
C9
MAC
makes holes in membrane of gram -
RBC
MAC
derived from unsaturated FA
leukotrienes
host defense
leukotrienes
role in inflammation and allergic rxn
leukotrienes
prostglandins
thromboxane
cylooxygenation
leokotrienes
lipoxygenation
slow reacting substances of anaphylaxis
leukotrienes
LT 100-1,000X potent as
histamine
prostaglandins
bronchioles
where there is allergen rxn
asthma
pricipal symptoms of anaphylaxis
histamine
secretory immunoglobin
IgA
protect surface tissue
IgA
most prevalent humoral antibodies produced
IgA
type AB blood
A and B antigens
found in plasma of type O
antibodies
anti-A
anti-B
incorrectly cross match blood in transfusion
agglutination of donor's erythrocytes
universal recipients
type AB
universal donor
type O
binds to receptors on basophil/mast cells
type I
anaphylatic
type I
cytotoxic
type II
immune complex
type III
cell mediated
type III
hay fever
type 1
autoimmune hemolytic anemias
type 2
goodpastures
type 2
antibody dependent cellular cytotoxicity
type 2
cytotoxic antibodies
type 2
immune complex
type 3
autoimmune dx:
SLE
RA
type 3
cell mediated
delayed type hypersensitiviy
type 4
granulomatous dx
type 4
cytotoxic antibodies :
IgG, IgM
formed against cell surface antigens
type 2
complement is involved
type 2
antibodies formed against exogenous/endogenous antigens
type 3
complement and leukocytes involved
type 3
mononuclear cells=
T lymphocytes
macrophages
type 4
interleukin and lymphokine production
type 4