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50 Cards in this Set
- Front
- Back
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Rb
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Tumor suppressor
Lost in: retinoblastoma, osteosarcoma |
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p53
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Tumor suppressor
Lost in: most human cancers, li fraumeni sro |
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BRCA1
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Tumor suppressor
Lost in: breast and ovarian cancer (BRCA2 = only breast) |
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BRCA2
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Tumor suppressor
Lost in: only breast CA (BRCA1 = breast & ovarian) |
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p16
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Tumor suppressor
Lost in: melanoma |
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APC
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Tumor suppressor
Lost in: colorectal |
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DPC
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Tumor suppressor
Lost in: Pancreatic Cancer (Mn: Deleted = Pancreatic Ca) |
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DCC
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Tumor suppressor
Lost in: Colon Cancer (MN: Deleted = Colon CA) |
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abl
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Proto-oncogene Tyrosine Kinase
Mutated In: CML |
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c-myc
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Protooncogene Transcription Factor
Mutated in: burkitt's lymphoma |
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bcl-2
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Protooncogene Anti-apoptotic Molecule
Mutated in: follicular and undifferentiated lymphomas |
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erb-B2
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Protooncogene Tyrosine Kinase
Mutated in: breast, ovarian and gastric carcinomas |
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ras
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Protooncogene GTPase
Mutated in: Colon carcinoma |
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L-myc
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Protooncogene Transcirption Factor
Mutated in: Lung tumors (L for lung) |
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N-myc
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Protooncogene Transcription Factor
Mutated in: Neuroblastoma (N for neuroblastoma) |
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ret
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Protooncogene Tyrosine Kianse
Mutated in: MEN 2a & 2b |
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c-kit
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Protooncogene Cytokine Receptor
Mutated in: Gastrointestinal Stromal Tumor (GIST) |
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Down Sro:
Neoplasia Risk |
ALL, AML
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Xeroderma pigmentosa
Neoplasia Risk |
melanoma, basal cell carcinoma and esp squamous cell carcinoma
(same as albinism) |
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albinism
Neoplasia Risk |
melanoma, basal cell carcinoma and esp squamous cell carcinoma
(same as xeroderma pigmentosa) |
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Down Sro:
Neoplasia Risk |
ALL, AML
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Xeroderma pigmentosa
Neoplasia Risk |
melanoma, basal cell carcinoma and esp squamous cell carcinoma
(same as albinism) |
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albinism
Neoplasia Risk |
melanoma, basal cell carcinoma and esp squamous cell carcinoma
(same as xeroderma pigmentosa) |
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Chronic atrophic gastritis
Neoplasia Risk |
Gastric adenocarcinoma
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pernicious anemia
Neoplasia Risk |
Gastric adenocarcinoma
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tuberous scleorsis
Neoplasia Risk |
astrocytoma, angiomyolipoma, cardiac rhabdomyoma
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actinic keratosis
Neoplasia Risk |
squamous cell carcinoma
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Barrett's eosphagitis
Neoplasia Risk |
esophageal adenocarcinoma
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Plummer Vinson Sro
Neoplasia Risk |
esophageal squamous cell carcinoma
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Cirrhosis
Neoplasia Risk |
hepatocellular carcinoma
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Ulcerative Colitis
Neoplasia Risk |
colonic adenocarcinoma
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Paget's Dz (Bone)
Neoplasia Risk |
osteosarcoma and fibrosarcoma
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Immunodeficiency
Neoplasia Risk |
malignant lymphomas
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AIDS
Neoplasia Risk |
aggressive malignant lymphomas, kapsoi's sarcoma
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Autoimmun Dz's
Neoplasia Risk |
lymphoma
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Acanthrosis Nigricans
Neoplasia Risk |
visceral malignancies (stomach, lung, breast uterus)
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Dysplastic Nevus
Neoplasia Risk |
malignant melanoma
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Radiation
Neoplasia Risk |
Sarcoma, papillary thyroid cancer
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have gone through
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protooncogenes
tumor suppressors predisposing conditions need to go through tumor markers ongocenic microbes, toxins and paraneopalstic sros cannot find a good list of translcoations. |
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t(9:22)
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CML
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t(8;21)
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AML & ALL
also 15;17 NB: t(10;14) → T cell ALL |
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t(15;17)
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AML & ALL
also t(8;21) |
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t(8;14)
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Burkitt's Lymphoma
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t(11;14)
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Mantle Cell Lymphoma
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t(14;18)
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follicular lymphoma
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t(10;14)
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T cell ALL
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t(11;22)
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Ewing Sarcoma
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t(21;21)
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Prostatic Adenocarcinoma
also t(7;21) and t(17;21) |
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t(7;21)
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prostatic adenocarcinoma
also t(21;21) and t(17;21) |
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t(17;21)
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prostatic adenocarcinoma
also t(21;21) and t(7;21)) |
