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31 Cards in this Set
- Front
- Back
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What's up w/ afferents and efferents of Lymph Nodes?
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Many Afferents
1 or more Efferents |
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Three main areas of LN's?
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Follicle
Medulla Paracortex |
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Where are the follicles and what goes on in the follicles?
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In outer cortex
Site of B-Cell localization and proliferation |
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What are the types of follicles and what's the difference?
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Primary Follicles are dense and dormant
Secondary Follicles have a pale central germinal center and are active |
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What makes up the LN Medulla?
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Medullary cords (closely packed lymphocytes and plasma cells)
Medullary Sinuses |
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What role to Medullary Sinuses play?
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Communicate w/ Efferent lymphatics
Contain Reticular cells and macrophages |
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Where is the paracortex and what lives there?
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Region between of cortex between follicles and medulla
Houses T-cells Contains the HEV's |
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What are HEV's? fxn?
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High Endothelial Venules
pathway through which T's and B's enter from blood |
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When is the Paracortex different sizes?
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Greatly enlarged in an extreme cellular response
Underdeveloped in DiGeorge syndrome |
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Which LN does this area drain into:
Upper limb, lateral breast? |
Axillary
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Which LN does this area drain into:
Stomach? |
Celiac
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Which LN does this area drain into:
Duodenum, jejunum? |
Superior Mesenteric
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Which LN does this area drain into:
Sigmoid Colon |
Colic--->inf. mesenteric
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Which LN does this area drain into:
Lower Rectum, Anal Canal above pectinate line? |
Internal Iliac
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Which LN does this area drain into:
Anal canal below pectinate line? |
Superficial inguinal
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Which LN does this area drain into:
Testes? |
Superficial and Deep Plexuses--->para aortic
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Which LN does this area drain into:
Scrotum? |
Superficial Inguinal
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Which LN does this area drain into:
Superficial Thigh? |
Superficial Inguinal
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Which LN does this area drain into:
Lateral side of dorsum of foot? |
Popliteal
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Right Lymphatic Duct vs Thoracic Duct?
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Right Lymphatic Duct drains right arm and right side of head
Thoracic Duct drains everything else |
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Where are T-cells in the spleen?
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Periarterial Lymphatic Sheath
Red Pulp |
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Where are B-cells in the spleen?
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Follicles w/in the white pulp
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Role of Macrophages in the spleen?
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Remove Encapsulated Bacteria
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What happens w/ Splenic Dysfxn?
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Dec IgM--->Dec C' activation--->dec C3b opsonization--->Inc susceptibility to encapsulated organisms
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Who are the encapsulated guys to worry about w/ splenic dysfxn?
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S. pneumoniae
H. influenzae Salmonella |
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What do you see on a blood smear after a splenectomy?
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Howell-Jolly bodies (nuclear remnants)
Target Cells Thrombocytosis |
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What is the main fxn of the Thymus?
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Site of T-cell Differentiation and Maturation
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Where does the thymus orginate embyronically?
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3rd branchial pouches
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What's in the Cortex of the Thymus?
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Dense w/ immature T-cells
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What's in the medulla of the Thymus?
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pale w/ mature T cells, epithelial reticular cells, and contains Hassall's corpuscles
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What happens at the Thymic Corticomedullary Junction?
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Positive (MHC restriction) and Negative (nonreactive to self) Selection occur here
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