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29 Cards in this Set
- Front
- Back
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Who are 7 major Immunosuppressants?
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Cyclosporine
Tacrolimus (FK506) Azathioprine Muromonab-CD3 (OKT3) Sirolimus (rapamycin) Mycophenolate Mofetil Daclizumab |
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MOA for Cyclosporine?
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Binds to cyclophilins
Complex blocks the differentiation and activation of T's by INHIBITING CALCINEURIN---> preventing production of IL-2 and its receptor |
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Clinical Uses for Cyclosporine?
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Suppress organ rejection
Selected Autoimmune disorders |
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Toxicity of Cyclosporine?
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Predisposes Pt to viral infections and lymphoma
Nephrotoxic |
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How to prevent Cyclosporine nephrotoxicity?
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Give w/ Mannitol Diuresis
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MOA for Tacrolimus
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Similar to Cyclosporine
Binds to FK-binding protein, inhibiting IL-2 and other cytokines |
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Clinical Uses of Tacrolimus?
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Organ Transplants
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Toxicity of Tacrolimus?
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Significant!
Nephrotoxic Peripheral Neuropathy HTN Pleural Effusion Hyperglycemia |
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MOA of Azathioprine?
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Antimetabolite precursor of 6-mercaptopurine that interferes w/ metabolism and synthesis of Nucleic Acids, i.e. its toxic to proliferating lymphocytes
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Clinical Uses of Azathioprine?
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Kidney Transplantation
Autoimmune Disorders (GN, hemolytic anemia, etc) |
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Toxicity of Azathioprine?
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Bone Marrow Suppression
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Drug Interaction of Azathioprine?
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Active metabolite (mercaptopurine) is metabolized by xanthine oxidase; thus the toxic effects may be increased by allopurinol
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MOA for Muromonab-CD3 (OKT3)?
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Monoclonal Ab that binds to Cd3 (epsilon chain) on surface of T-cells.
Blocks cellular interaction w/ CD3 responsible for T-Cell signal transduction |
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Uses for Muromonab-CD3?
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Immunosuppression after kidney transplant
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Toxicity of OKT3?
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Cytokine release syndrome, hypersensitivity rxn
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MOA of Sirolimus (rapamycin)?
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Binds to mTOR
Inhibits T-cell prolif in response to IL-2 |
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Uses for Sirolimus (rapamycin)?
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Immunosuppression after kidney transplant in combo w/ cyclosporine and corticosteroids
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Toxicity of Sirolimus (rapamycin)?
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Hyperlipidemia
Thrombocytopenia Leukopenia |
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MOA for Mycophenolate Mofetil?
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Inhibits de novo guanine synthesis and thus blocks lymphocyte proliferation
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MOA for Daclizumab?
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Monoclonal Ab w/ high affinity for the IL-2 Receptor on activated T's
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Recombinant IL-2 and its uses?
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Aldesleukin
Renal Cell Carcinoma Metastatic Melanoma |
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Recombinant EPO?
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Erythropoietin
Anemias (esp in RF) |
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Recombinant Granulocyte Colony-Stimulating Factor and its uses?
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Filgrastin
Recovery of Bone marrow |
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Recombinant Granulocyte-Macrophage Colony-Stimulating Factor?
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Sargramostim
recovery of bone marrow |
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uses of Recombinant Alpha-Interferon?
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Hep B and C
Kaposi's Sarcoma Leukemias Malignant Melanoma |
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uses of recombinant beta-interferon?
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Multiple Sclerosis
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uses of recombinant gamma-interferon?
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CGD
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What is recombinant IL-11 and its uses?
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Oprelvekin
Thrombocytopenia |
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uses for recombinant Thrombopoietin?
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Thrombocytopenia
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