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32 Cards in this Set

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NF- κB
transcription factor which induces cytokine prodxn in response to microbial infx
#immunology #molecules
NOD2
[Nucleotide Binding Oligomerization Domain]

intracellular microbial receptor which which triggers NF- κB transcription factor → cyokine prodxn
#immunology #molecules
DOC: anaphylaxis
Epinephrine
#pharmacology #immunology
How does mom's blood type determine whether the baby could suffer from hemolytic dz?
Blood Types A & B usually have IgM anti-B & anti-A

Mom w/ Blood Type O often has IgG anti-A and anti-B

Mom with blood type O more likely to have hemolytic dz for baby than otherwise
#pathology #reproductive #immunology
"Hotdog" looking inclusions in eosinophils
Major Basic Protein

Kills helminths
damages epithlium
#immunology
#hematology
immunolytic effects of corticosteroids
inhibit PLA2
inhibit phagocytosis
inhibit IL1 prodxn
#pharmacology #immunology
Loss of FAS → SLE

pathogenesis?
impaired "Clonal deletion" of activated T's by CTL's in peripheral ts
#pathology #hematology #immunology
Recurrent Bacterial and Viral Infx
indicative of combined T and B cell deficiency (SCID)
#immunology #pathology
Pt cannot clear Giardia infx
IgA deficiency
#microbiology #immunology #gastrointestinal
Pt cannot clear Giardia infx
IgA deficiency
#microbiology #immunology #gastrointestinal
Sequence of Ig Isotype Switching
Requires interaction of B cell CD40 and T cell CD40L (CD154)

Once you go on to the next you cannot come back

M D G E A
#hematology #immunology
Sequence of Ig Isotype Switching
Requires interaction of B cell CD40 and T cell CD40L (CD154)

Once you go on to the next you cannot come back

M D G E A
#hematology #immunology
Dimeric IgA
only found in secretions never in blood
#immunology #hematology
Dimeric IgA
only found in secretions never in blood
#immunology #hematology
Killed vaccines generate what kind of response and why?
humoral response instead of T cell response because they can't actually infect cells, so they never get expressed on MHC I so they never induce mCD8T's
#microbiology #immunology
CD40
CD40 is a receptor on the B cell for CD154 aka CD40L on T cells

This interaction allows for class switching to occur
#immunology
HLA
class I vs class II
HLA Class I = MHC Class I
large α, β2 microglobulin

Includes HLA-A, HLA-B & HLA-C

HLA Class II = MHC Class II
Equal sized α and βglobulins

Inclues HLA-DR, HLA-DP and HLA DQ
#rheumatology #immunology
Killed bacterial vaccines
Cholera
Anthrax
Pertussis
Plague
#microbiology #immunology
Live attenuated bacterial vaccines
BCG: tuberculosis
thyphoid vaccine
Tularemia
#microbiology #immunology
Capsular polysaccharide vaccines
Pneumococcus
Hib
Meningococcus
#microbiology #immunology
Ig which does not contribute to Neisseria killing
IgA cannot trigger complement cascade

only IgM and IgG

too much IgA leaves pts vulnerable to Neisseria by blocking IgG and IgM from epitopes
#micobiology #immunology
IL10
produced by TH2 and inhibits the synthesis of IFNγ
#immunology
Hib Vaccine
polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo
#immunology
#microbiology
Hib Vaccine
polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo
#immunology
#microbiology
Non-typable Haemophilus influenzae
unencapsulated

commensural
#immunology
#microbiology
Non-typable Haemophilus influenzae
unencapsulated

commensural
#immunology
#microbiology
PRP polysaccharide
capsular antigen of Hib

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo
#microbiology
#immunology
PRP polysaccharide
capsular antigen of Hib

polyribosysl-ribitol-phosphate (PRP) - polysaccharide conjugated with protein toxoid from either diphtheria or tetanus

this allows for T cell processing and the production of memory humoral immunity in children under age 18 mo

may be given as early as 2 mo
#microbiology
#immunology
Characterize eosinophil fnx
Antibody-dependent cytotoxicity

Eosinophils have an IgE Fx

degranulation releases major basic protein

eosinophils also contain histaminase which degraes histamine and decreases severity of atopy also leukotrienes and peroxidases which ↑ inflammation
#immunology
Why is sputum green during pneumonia?
Myeloperoxidase is a blue green heme based pigmented molecule within the azurophilic granules of PMN's which catalyzes the prdxn of HOCl from h2O2
#immunology
CD14
Monocyte-M∅ lineage
#immunology
PMH: Blunt Trauma to Abdomen c Emergent Surgery presents with Bacteremia
Splenectomy

vulnerable to encapsulated organisms

Pneumococcus
Meningococcus
H influenzae
#microbiology #immunology