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8 Cards in this Set

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α2γ2
HbF, Fetal Hemoglobin

Synthesized in fetal liver starting at the end of the 1st trimester

Vast majority of hemoglobin in newborn, gradually replaced over first 6 mos.

no β subunits = no charged histidine residues which interact with 2,3 BPG → HbF has stronger affinity for O2 than maternal
HbF
α2γ2

HbF, Fetal Hemoglobin

Synthesized in fetal liver starting at the end of the 1st trimester

Vast majority of hemoglobin in newborn, gradually replaced over first 6 mos.

no β subunits = no charged histidine residues which interact with 2,3 BPG → HbF has stronger affinity for O2 than maternal
α2δ2
Hemoglobin A2
α2δ2 (alpha 2 delta 2)

Normal variant, 5% of adult hemoglobin
Hemoglobin A2
alpha2 delta2

Normal variant, 5% of adult hemoglobin
Hemoglobin Gower
ζ2ε2 zeta2 epsilon2

earliest hemoglobin found in fetus

synthed by yolk sac
ζ2ε2
Hemoglobin Gower

zeta2 epsilon2

earliest hemoglobin found in fetus

synthed by yolk sac

replaced by Hemoglobin Portland (zeta2 gamma2)
γ4
Hemoglobin Bart

homozygous alpha thalassemia when no alpha chains can be synthed

very high affinity for O2, does not release → ts hypoxia, hydrops fetalis → fetal death
Hemoglobin Bart
γ4

homozygous alpha thalassemia when no alpha chains can be synthed

very high affinity for O2, does not release → ts hypoxia, hydrops fetalis → fetal death