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38 Cards in this Set
- Front
- Back
carbohydrates |
*lewis *P *I (similar to ABO--genes encode for a specific glycosyltransferase) |
|
Rh |
is a protein only |
|
Lewis |
Codes for the addition of fucose to the Type 1 chain (precursor 1) |
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H/h |
*typical cold reactive antibody (IgM) *rare antibody: IgM/IgG formed by bombay *On Bench (pre warm to remove or cold/enzymes to enhance) |
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Se |
*codes for a fucosaltransfurase which adds a fucose to type 1 precursors (can add A/B antigens to these) |
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fut 2 |
se |
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fut 3 |
Le |
|
fut 1 |
ABO and is added on to precursor 2 |
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Le a |
*le a is made predominately when no se is present |
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Le b |
*is made when se is present *there will be a small amount of le a present but not on RBCs |
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Le, Se, A/B/H |
Secretions: Lea, Leb, A, B, H RBC: A, B, H, Le (a-b+) |
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lele, Se, A/B/H |
Secretions: A, B, H RBC: A, B, H, Le (a-b-) |
|
Le, sese, A/B/H |
Secretions: Lea RBC: A, B, H, Le (a+b-) |
|
lele, sese, A/B/H |
Secretions: none RBC: A, B, H, Le(a-b-) |
|
Le, sese, hh, A/B |
Secretions: Lea RBC: Oh, Le (a+b-) |
|
Le, Se, hh, A/B |
Secretions: Lea, Leb, A/B/H RBC: Le(a-b+), A, B (not integral though--precursor 1) |
|
Le characteristics |
*not well developed at birth *ag production may be depressed in pregnancy *adsorb reversibly onto the RBC surface |
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Le clinical importance |
*transfusion *pregnancy *transplantation |
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Le on bench |
Remove: prewarm enhance: cold/enzymes |
|
I/i |
*not co dominant *adults big I *babies little i *not associated with HDN |
|
non codominant ag |
*D *I/i *Le |
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I/i system disease association |
*stress on marrow: more i *infectious mono, myeloid leukemia--auto i *mycoplasma pneumonia--auto anti I |
|
P/Glob system |
*2 precursor molecules, substrate for sequential addition *not expressed at birth *found on other blood cells, tissues, etc |
|
P1 and Pk |
assigned to the P1PK Blood group system
|
|
P, LKE, PX2 |
*globoside blood group |
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P1 |
Freq: 75% Ag: P1, P Ab: none |
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P2 |
Freq: 25% Ag: P Ab: anti P1(IgM) |
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p |
freq: <1% Ag: none Ab: anti P1, PK, P--HTR |
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P1K |
freq:1% Ag: P1,PK Ab: anti P--HTR/HDFN |
|
P2K |
Freq: <1% ag: Pk Ab: anti P and P1--HTR/HDFN |
|
receptor for human parvovirus |
*P |
|
Parasitic infections |
anti-P1 |
|
Early abortions |
anti-PP1Pk or anti P |
|
PCH |
auto anti-P |
|
Pk receptor |
associated w/ shiga toxins |
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MN antibodies |
*don't bind complement *not normally clinically significant *mix of IgM/IgG *may show dosage *destroyed by enzymes |
|
Lutheran system |
*Lu(a) is very rare, Lu (b) >92% *not well developed at birth *may be glycoproteins *sometimes see weak mixed field looking agglutinations |
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Lewis says |
H ey, it's kind of COLD, outside of M y N ice P retty L ittle I gloo! |