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38 Cards in this Set

  • Front
  • Back

carbohydrates

*lewis


*P


*I


(similar to ABO--genes encode for a specific glycosyltransferase)

Rh

is a protein only

Lewis

Codes for the addition of fucose to the Type 1 chain (precursor 1)

H/h

*typical cold reactive antibody (IgM)


*rare antibody: IgM/IgG formed by bombay


*On Bench (pre warm to remove or cold/enzymes to enhance)

Se

*codes for a fucosaltransfurase which adds a fucose to type 1 precursors (can add A/B antigens to these)

fut 2

se

fut 3

Le

fut 1

ABO and is added on to precursor 2

Le a

*le a is made predominately when no se is present

Le b

*is made when se is present


*there will be a small amount of le a present but not on RBCs

Le, Se, A/B/H

Secretions: Lea, Leb, A, B, H


RBC: A, B, H, Le (a-b+)

lele, Se, A/B/H

Secretions: A, B, H


RBC: A, B, H, Le (a-b-)

Le, sese, A/B/H

Secretions: Lea


RBC: A, B, H, Le (a+b-)

lele, sese, A/B/H

Secretions: none


RBC: A, B, H, Le(a-b-)

Le, sese, hh, A/B

Secretions: Lea


RBC: Oh, Le (a+b-)

Le, Se, hh, A/B

Secretions: Lea, Leb, A/B/H


RBC: Le(a-b+), A, B (not integral though--precursor 1)

Le characteristics

*not well developed at birth


*ag production may be depressed in pregnancy


*adsorb reversibly onto the RBC surface

Le clinical importance

*transfusion


*pregnancy


*transplantation

Le on bench

Remove: prewarm


enhance: cold/enzymes

I/i

*not co dominant


*adults big I


*babies little i


*not associated with HDN

non codominant ag

*D


*I/i


*Le

I/i system disease association

*stress on marrow: more i


*infectious mono, myeloid leukemia--auto i


*mycoplasma pneumonia--auto anti I

P/Glob system

*2 precursor molecules, substrate for sequential addition


*not expressed at birth


*found on other blood cells, tissues, etc

P1 and Pk

assigned to the P1PK Blood group system


P, LKE, PX2

*globoside blood group

P1

Freq: 75%


Ag: P1, P


Ab: none

P2

Freq: 25%


Ag: P


Ab: anti P1(IgM)

p

freq: <1%


Ag: none


Ab: anti P1, PK, P--HTR

P1K

freq:1%


Ag: P1,PK


Ab: anti P--HTR/HDFN

P2K

Freq: <1%


ag: Pk


Ab: anti P and P1--HTR/HDFN

receptor for human parvovirus

*P

Parasitic infections

anti-P1

Early abortions

anti-PP1Pk or anti P

PCH

auto anti-P

Pk receptor

associated w/ shiga toxins

MN antibodies

*don't bind complement


*not normally clinically significant


*mix of IgM/IgG


*may show dosage


*destroyed by enzymes

Lutheran system

*Lu(a) is very rare, Lu (b) >92%


*not well developed at birth


*may be glycoproteins


*sometimes see weak mixed field looking agglutinations

Lewis says

H ey, it's kind of COLD, outside of M y N ice P retty L ittle I gloo!