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36 Cards in this Set
- Front
- Back
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What is Platelet aggregation?
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Formation of Fibrinogen bridges between glycoprotein IIb/IIIa and other platelets
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Coagulation requires ____ for synthesis.
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Vitamin K
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What is the action of antithrombin?
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Forms a complex with clotting factors and inhibits factors activity
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What is the enzyme that digests a clot?
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Plasmin
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What is plasminogen used to form?
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Plasmin
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A thrombosis, a ____, is formed in the arteries as a result of ____ and formed in the veins as a result of ____.
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Blood Clot
Damage to the Blood vessel wall Stagnation of Blood |
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What is the two prototypic anticoagulant?
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Heparin
Warfarin |
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What is the mechanism of action of Heparin?
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Helps antithrombin inactivate clotting factors
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How is Heparin administered?
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Parentral
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What are the adverse effects of Heparin?
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Hemorrhage
Heparin-Induced Thrombocytopenia (Antibodies against Heparin-Antithrombin complex) |
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What drug is given as an antidote to Heparin overdose?
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Protamine Sulfate
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Protamine Sulfate is ____.
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Antidote to Heparin overdose
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What is the test called that controls the dosage of heparin?
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Activated Partial Thromboplastin Time (aPTT)
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What are the difference between Heparin and LMW Heparin?
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Can be given on a fixed-dose schedule and do not require monitoring
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If the drug ends in -aparin it is a
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LMW Heparin
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What is the uses of Heparin?
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Prevention and Treatment of DVT
Prevention of MI |
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What are the direct thrombin inhibitors?
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Bivarlirudin, lepirudin, and argatroban
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What is the prototypic oral anticoagulant?
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Warfarin
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Warfarin is a ____.
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Oral Anticoagulant
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What is the action of Warfarin?
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Antagonist of Vitamin K
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What are the uses of Warfarin?
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Long-term prevention of thrombosis
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What is the test used to measure the effect of Warfarin?
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Prothrombin Time (PT)
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What are the adverse effects of Warfarin?
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Hemorrhage
Category X |
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What are the contraindications of Warfarin?
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Heparin
Aspirin Acetaminophen |
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What is the treatment of Warfarin overdose?
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Vitamin K
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Vitamin K is used to treat ___.
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Warfarin overdose
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What is the prototypic antiplatelet drug?
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Aspirin
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What is aspirin used for?
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Prevention of MI and Stroke
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What are the adverse effects of Aspirin?
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GI Bleeding
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___ and ____ are the ADP receptor antagonist. ADP activates the platelet.
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Ticlopidine
Clopidogrel |
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What are the uses of ADP Antagonist?
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Prevention of MI and Stroke
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What is the prototype of the Thrombolytic drugs?
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Streptokinase
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What does streptokinase do?
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Binds to plasminogen to activate it
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What is streptokinase used for?
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MI
DVT Pulmonary Embolism |
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What two drugs are similar to Streptokinase?
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Alteplase
Tenecteplase |
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What are Alteplase and Tenecteplase used for?
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Treatment of Stroke or MI
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