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36 Cards in this Set

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  • Back
What is Platelet aggregation?
Formation of Fibrinogen bridges between glycoprotein IIb/IIIa and other platelets
Coagulation requires ____ for synthesis.
Vitamin K
What is the action of antithrombin?
Forms a complex with clotting factors and inhibits factors activity
What is the enzyme that digests a clot?
Plasmin
What is plasminogen used to form?
Plasmin
A thrombosis, a ____, is formed in the arteries as a result of ____ and formed in the veins as a result of ____.
Blood Clot
Damage to the Blood vessel wall
Stagnation of Blood
What is the two prototypic anticoagulant?
Heparin
Warfarin
What is the mechanism of action of Heparin?
Helps antithrombin inactivate clotting factors
How is Heparin administered?
Parentral
What are the adverse effects of Heparin?
Hemorrhage
Heparin-Induced Thrombocytopenia
(Antibodies against Heparin-Antithrombin complex)
What drug is given as an antidote to Heparin overdose?
Protamine Sulfate
Protamine Sulfate is ____.
Antidote to Heparin overdose
What is the test called that controls the dosage of heparin?
Activated Partial Thromboplastin Time (aPTT)
What are the difference between Heparin and LMW Heparin?
Can be given on a fixed-dose schedule and do not require monitoring
If the drug ends in -aparin it is a
LMW Heparin
What is the uses of Heparin?
Prevention and Treatment of DVT
Prevention of MI
What are the direct thrombin inhibitors?
Bivarlirudin, lepirudin, and argatroban
What is the prototypic oral anticoagulant?
Warfarin
Warfarin is a ____.
Oral Anticoagulant
What is the action of Warfarin?
Antagonist of Vitamin K
What are the uses of Warfarin?
Long-term prevention of thrombosis
What is the test used to measure the effect of Warfarin?
Prothrombin Time (PT)
What are the adverse effects of Warfarin?
Hemorrhage
Category X
What are the contraindications of Warfarin?
Heparin
Aspirin
Acetaminophen
What is the treatment of Warfarin overdose?
Vitamin K
Vitamin K is used to treat ___.
Warfarin overdose
What is the prototypic antiplatelet drug?
Aspirin
What is aspirin used for?
Prevention of MI and Stroke
What are the adverse effects of Aspirin?
GI Bleeding
___ and ____ are the ADP receptor antagonist. ADP activates the platelet.
Ticlopidine
Clopidogrel
What are the uses of ADP Antagonist?
Prevention of MI and Stroke
What is the prototype of the Thrombolytic drugs?
Streptokinase
What does streptokinase do?
Binds to plasminogen to activate it
What is streptokinase used for?
MI
DVT
Pulmonary Embolism
What two drugs are similar to Streptokinase?
Alteplase
Tenecteplase
What are Alteplase and Tenecteplase used for?
Treatment of Stroke or MI