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129 Cards in this Set
- Front
- Back
The donor history questionnaire was developed by ?
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AABB (American Association of Blood Banks)
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What are the 3 steps in the donor screening process?
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1. registration 2. health history 3. physical exam
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A donor applicant who has received a tattoo or permanent makeup at a facility that it not state regulated must be deferred for how long?
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1 year
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A donor applicant with a history of hepatitis after his 11th birthday will be deferred for how long?
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permanently deferred
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Donor applicants taking Warfarin/Coumadin will be deferred for how long?
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1 week
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Donor applicants who have recently received a Hepatitis B vaccine will be deferred for how long?
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28 days
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A donor applicant who tests positive for hepatitis B surface antigen will be deferred for how long?
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permanently deferred
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A donor applicant who tests positive for hepatitis B antigen on more than one occasion will be deferred for how long?
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permanently deferred
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Donor applicants who have recently received a vaccine for viruses OTHER THAN German measles, Chickenpox, or hepatitis will be deferred how long?
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2 weeks
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A donor applicant with past or present lab evidence of hepatitis C virus will be deferred for how long?
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permanently deferred
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A donor who has received a rabies vaccine after an animal bite must be deferred for how long?
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1 year
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Donor applicants who have recently received the German measles or Chickenpox (Varicella-zoster) vaccines will be deferred how long?
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4 weeks
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Donor applicants taking bovine insulin will be deferred for how long?
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indefinitely
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A donor applicant must wait how long to donate blood after pregnancy?
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6 weeks
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A donor applicant with past or present lab evidence of human T-cell lymphotropic virus will be deferred for how long?
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permanently deferred
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Donor applicants who have hepatitis B immune globulins will be deferred for how long?
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1 year
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A donor applicant with past or present lab evidence of HIV infection will be deferred for how long?
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permanently deferred
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A donor applicant with a history of babesiosis or Chagas disease will be deferred for how long?
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permanently deferred
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A donor applicant with a history of malaria or who has lived in a country for 5 consecutive years or more where malaria is endemic will be deferred for how long?
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3 years
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A donor applicant with a family history of CJD/Mad Cow disease will be deferred for how long?
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permanently deferred
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A donor applicant that has traveled to an area where malaria is endemic will be deferred for how long?
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1 year after departure
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A donor applicant who has lived 3 months or more in the U.K. from 1980-1996 will be deferred for how long?
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indefinitely
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Donor applicants taking Accutane will deferred for how long?
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1 month
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A donor applicant who has received dura mater or human pituitary growth hormone will be deferred for how long?
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permanently deferred
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A donor applicant who has lived 5 years or more in Europe from 1980 to the present will be deferred for how long?
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indefinitely
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Donor applicants taking Propecia will be deferred for how long?
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1 month
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Any donor applicant who has received a blood transfusion or human tissues must be deferred for how long?
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1 year
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A donor applicant who has used a needle to self-administer nonprescription drugs will be deferred for how long?
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permanently deferred
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Donor applicants taking aspirin will be deferred for how long?
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2 days FOR PLATELET DONORS ONLY
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Donor applicants taking Plavix will be deferred for how long?
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14 days FOR PLATELET DONORS ONLY
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A donor applicant who has been incarcerated for more than 72 hours must be deferred for how long?
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1 year
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The antecubital site where a blood donation is to be made from must be sterilized with 10% __ or .7% __.
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10% Betadine (povidone-iodine) or 0.7% iodine (aqueous iodophor)
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What size needle is normally used during a blood donation?
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16 gauge
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If a donor begins to complain of weakness, dizziness, pallor, nausea and vomiting, what should you do?
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1. remove needle and tourniquet 2. elevate legs above head 3. apply cold compresses to forehead and back of neck
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If a donor faints (syncope) what should you do?
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Apply cold compresses on back of neck.
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If a donor has a hematoma, what should you do to minimize the bruise?
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apply pressure for 7-10 mins, then ice for 5 mins
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If a donor begins having convulsions while donating blood, what should you do?
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1. call for help 2. prevent donor from falling or injuring himself 3. ensure donor has adequate airway
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The donor should notify the blood center if they experience any reactions from their blood donation within how long?
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2 weeks
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Donations made to the general population are called ?
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allogeneic
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Donations made for the donor's personal use are called ?
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autologous
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Donations contributed for use by a specific person other than the donor are called ?
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directed donations
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What are the 5 advantages of an autologous blood donation?
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1. prevents transmission of disease 2. prevents alloimmunization 3. supplements the blood supply 4. prevents febrile and allergic reactions 5. reassures the patient
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What are the 5 disadvantages of making an autologous blood donation?
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1. inventory control 2. preoperative anemia 3. increased cost 4. high wastage 5. increased incidence of adverse reaction to donation
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When blood is drawn and stored before the anticipated date of surgery, this is called a __ donation.
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preoperative
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Removing units of blood at the beginning of surgery and reinfusing them at the end of surgery is called a __ donation.
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normovolemic
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When a medical device washes, filters, and concentrates blood during an operation, this is called __ __.
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blood recovery
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A donor applicant's hemoglobin must be at least __ g/dL to donate.
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12.5 g/dL
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A donor applicants hematocrit must be at least __% to donate.
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38%
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A donor applicants temp must be less than or equal to __ degrees Celsius.
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37.5
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A donor applicants must be at least __ years old to donate.
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17, or in accordance with state law (18 in Delaware)
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To make a preoperative donation, a patient's hemoglobin must be at least __ g/dL.
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11
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To make a preoperative donation, a patient's hematocrit must be at least __%.
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33
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A patient can make a preoperative donation up to how many hours before an operation?
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72
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You must wait how many days after a blood donation to make another one?
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56 days
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When blood components are separated and the remaining blood is returned to the donor, this is called ?
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apheresis
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When white blood cells are separated for a donation, this is called ?
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leukapheresis
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Plateletpheresis donations must be made at least how many hours apart and how many times per week?
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48 hours apart, no more than twice per week
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What immunoglobulin levels are monitored when making a donation for frequent plasmapheresis?
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IgG and IgM
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After donating for red cell apheresis, deferral for making another donation is how long?
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16 weeks
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Testing blood for ABO, D type, and antibody screening is what category of test?
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Immunohematologic testing
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Testing blood for infectious agents is called what category of testing?
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infectious disease screening
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NAT stands for?
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nucleic acid test
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What does HBsAg stand for?
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Hepatitis B surface antigen
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What does anti-HBc stand for?
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antibody to Hepatitis B core
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When testing for Trypanosoma cruzi (Chagas disease) we are really looking for what antibody?
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IgG antibody to T. cruzi
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HTLV stands for?
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Human T-cell lymphotropic virus
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Certain people require blood that has been tested for CMV. What are the 3 groups of people?
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1. immunocompromised 2. babies 3. pregnant women (or women of child bearing age)
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What 4 tests are performed on blood to check for hepatitis?
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1. HBsAg (hepatitis B surface antigen) 2. anti-HCV (antibody to hepatitis C virus) 3. Anti-HBc (antibody to hepatitis B core) 4. HCV NAT (hepatitis C virus nucleic acid test)
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RPR stand for?
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rapid plasma reagin
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Syphilis is caused by what infectious agent?
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Treponema pallidum
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What test is used to check blood for syphilis? What test is used to confirm?
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RPR test, confirmed with Fluorescent treponemal antibody adsorption test
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What does EIA stand for?
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Enzyme-linked Immumosorbent Assay
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Indirect EIA detects what?
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antibodies
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Sandwich EIA detects what?
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antigens
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What is the advantage of a NAT over other tests?
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NAT can detect VERY low numbers of viral copies in plasma, even before antibodies appear
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Which kinds of hepatitis can be transmitted by IV?
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B, C, D
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HBsAG (hepatitis B surface antigen) tests for a __ on the viral surface that indicates the patient has been infected.
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protein
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What antibody appears in a patient after HBsAG but before symptoms appear?
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anti-HBc (antibody to hepatitis B core antibody)
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What makes a retrovirus different from a DNA virus?
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A retrovirus has reverse transcriptase that allows the virus to convert RNA to DNA and integrate the new DNA into the cell
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HTLV-1 is associated with ?
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adult T-cell leukemia
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Even after blood has been leukareduced, some WBCs remain and the patient can still be infected by __.
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HTLV-1
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What 4 infectious agents can trigger a look-back investigation?
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1. hepatitis 2. HIV 3. HTLV 3. WNV
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Chagas disease is the result of what infectious agent?
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Trypanosoma cruzi
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Trypanosoma cruzi is transmitted by what bug?
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Reduviid bug
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What substance supports ATP generation by the glycolytic pathway?
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dextrose
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What substance acts as a substrate for red cell ATP synthesis?
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adenine
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What substance prevents coag by chelating calcium and protects donated RBC membranes?
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citrate
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What substance prevents an excessive decrease in donor blood pH?
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sodium biphsophate
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What substance is an osmotic diuretic that acts as a membrane stabilizer?
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Mannitol
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CPD and CP2D can allow blood to be stored for how many days?
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21
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CPDA-1 can allow blood to be stored for how long?
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35 days
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Additive solution AS-5 can allow blood to be stored for how long?
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42 days
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CPD stands for?
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Citrate-phosphate-dextrose
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What increases when blood is stored?
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potassium and plasma hemoglobin due to RBC lysis
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RBC ATP and 2,3 DPG go (up or down?) once blood has been stored?
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down
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Platelet-rich plasma (PRP) is expelled into a satellite bag when whole blood undergoes a (light or heavy?) spin.
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light
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Platelets are separated from plasma when PRP is spun at a (heavy or light?) spin?
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heavy
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Plasma can be further processed into __ __ __ during a heavy spin.
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fresh frozen plasma (FFP)
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FFP (fresh frozen plasma) can be processed into __.
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cryoprecipitate
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A unit of whole blood increases a recipient's hemoglobin by how much?
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1g/dL
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A unit of whole blood increases a recipient's hematocrit by what percent?
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3%
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RBC component must be stored at what temp?
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1-6C
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Frozen RBCs must be stored at what temp?
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-65C or lower
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Frozen RBCs remain viable for how long?
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10 years
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Deglycerolized or washed RBCs must be stored at 1-6C and are good for how long?
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24 hours
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Irradiated RBCs must be stored at what temp?
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1-6C
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Irradiated RBCs are good for how long?
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28 days from irradiation or their pre-irradiation expiration date
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Fresh frozen plasma (FFP) must be stored at what temp?
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-18C or less
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If stored at -18C, FFP is good for how long?
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1 year
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Once thawed, FFP and PF24 are good for how long?
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24 hours
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Leukocyte reduced apheresis platelets should be stored at what temp?
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20-24C
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Leukocyte reduced apheresis platelets are good for how long?
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5 days
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Cytokines produced by WBCs can cause _ reactions.
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febrile reactions
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Cytokines produced by leukocytes can cause what 3 reactions?
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1. fever 2. shaking 3. chills
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Removing WBCs does not prevent GVH disease (graft VS host) but what does?
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irradiation
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The final RBC apheresis must have at least __ g of hemoglobin and a minimum volume of __ mL.
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51g, 153mL
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Automatic collection of 1 unite of apheresis RBCs takes place once every __ weeks.
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8
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What do we wash RBCs with to remove plasma proteins that might cause allergic, febrile, or anaphylatic reactions?
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saline
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GVH disease is a reaction to __ on T cells.
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HLAs
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Which is better: Apheresis platelets or pooled platelets?
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apheresis
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FFP and PF24 contain all coag factors, but PF24 is deficient in what coag factor?
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8
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Patients in need of which 4 factors can be given FFP?
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II, V, X, XI
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What 6 reasons are there for giving someone FFP?
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1. coag deficiency 2. mass transfusion 3. warfarin 4. therapeutic plasmapheresis 5. live disease and factor deficiency 6. DIC
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FFP and PF24 thaw in __ mins and should be stored at what temp?
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30-45 mins, 1-6C
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If FFP and PF24 have not been transfused within 24 hours, it can be stored at 1-6C and used within __ days.
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5
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Thawed plasma cannot be used to replace factor __.
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8
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CRYO must have __ mg of fibrinogen and __ international units of factor __ per unit.
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150mg, 80 IU, factor 8
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CRYO contains what factors?
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VWF, fibrinogen, 8, fibronectin, 13
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AABB standards required all facilities to convert to __ by May 1, 2008.
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ISBT 138
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