Blood Bank

Front 1

What 3 diseases are associated with McLeod's syndrome (absence of Kx)?

Back 1

1) Chronic Granulomatous Disease
2) Retinitis Pigmentosa
3) Muscular Dystrophy

Front 2

what is the minimum h/h to donate an autologous donation?

Back 2

11g/dL/33%

Front 3

What drug has indefinite deferral?

Back 3

Etretinate (Tegison) Psoriasis drug

Front 4

Why are blood or products washed?

Back 4

1) IgA deficiency
2) Neonatal Autoimmune Thrombocytopenia (NATP)
3) Repeted Febrile nonhemolytic transfusion reactions (FNHTR)

Front 5

What race has the most Lewis A/B antibodies?

Back 5

African Americans

Front 6

The presence of H. pylori aids this blood group in attaching to gastric epithelium:

Back 6

Lewis B

Front 7

Anti I is associated with what conditions?

Back 7

1) Mycoplasma Pneumonia
2) Cold agglutanin disease
3) Lymphomas

Front 8

Little i is associated with what condition?

Back 8

Mono

Front 9

Paroxysmal Cold Hematuria is associated with what?

Back 9

Donath-Landsteiner biphasic hemolysin
ANTI P TgG colds coat lyses warm

Front 10

What is important about the Donath-Landsteiner test

Back 10

IgG coats cold lyses warm..
Anti P biphasic hemolysin

Front 11

What are the "R" Weiner haplotypes?

Back 11

R1= DCe
R2=DcE
R0= Dce
Rz= DCE

Front 12

What are the "r" Wiener haplotypes?

Back 12

r'= dCe
r"= dcE
r= dce
ry= dCE

Front 13

What antigen is associated with the most significant HDN?

Back 13

Rh(D)

Front 14

What blood group involves the most significant cause of HDN/

Back 14

ABO

Front 15

What factor is not present in cryo?

Back 15

Factro XII (12) AKA prekallikrein or HMW kinonogen

Front 16

How does glycerol affect RBC's?

Back 16

in vivo/vitro hemolysis. Water moves into the cells.

Front 17

WHat causes deglycerolized blood to form an insoluble jelly-like mass?

Back 17

Donor has SS trait

Front 18

What is the most common form of HDN/

Back 18

GROUP O mother anti

Front 19

What factors are increased in stored whole blood?

Back 19

H+ and K+

Lactate and hemoglobinn are also increased (hemolysis)

Front 20

What is decreased in stored blood?

Back 20

2,3 DPG

Front 21

What are three ways to detect acquired B antigen?

Back 21

1) Reacetylation using acetic anhydride.
2) Monoclonal anto B should be negative
3) Use of lectins griggonia simplicofoli and phaseous lunatis.

Front 22

What are the naturally occurring antibodies?

Back 22

Lewis I/i P M A N
LIPMAN
Basically the carbohydrate antibodies
(IgM)

Front 23

What lectin agglutinates with H antigen?

Back 23

Ulex europaeus

Front 24

What is the deferral for history of CJD versus travel to CJD areas?

Back 24

Both are indefinite

Front 25

What RBC antigen is decreased by enzyme activity?

Back 25

MNS
Duffy

Front 26

What RBC antigens do not cause HDN?

Back 26

PIL
P1
Le A/Le b
I/i

Front 27

What RBC antigen is not affected by enzymes?

Back 27

KELL KELL KELL

Front 28

What are compatible fluids fro transfusion?

Back 28

1) Normal saline
2) ABO compatible plasma
3) 5% albumin

Front 29

Cryoprecipitate is made by:

Back 29

Thaw FFP at 4 degrees C.
Remove supernatant
This leaves cryo-reduced plasma

Front 30

Cryoreduced plasma has less of the following factor:

Back 30

vWF because it stays with precipitate.
Given in TTP because less multimers.

Front 31

What RBC antigen confers P.vivax resistence?

Back 31

Fy(a-/b-)

Front 32

What solutions are incompatible with blood transfusions?

Back 32

1) 0.45 % saline
2) D5W
3) TPN: shrinkage
4) Antibiotics
5) Lactated ringers

Front 33

Why is lactated ringers incompatible with blood transfusion?

Back 33

It contains 3mEQ Ca/L that counters citrate in blood products

Front 34

Contraindications to platelet administration include:

Back 34

1) TTP/HUS
2) HIT type II

Front 35

Which has more H antigen A1 or A2?

Back 35

A2

Front 36

What is the H antigen density on RBC's from most to least?

Back 36

O>A2>B>A2B>A1>A1B>Oh

Front 37

What lectin differentiates between A1 and A2?

Back 37

Dolichos Biflorus agglutinates A1

Front 38

Enzyme enhanced RBC antigens include:

Back 38

ARK (A rotten Kid)
ABO Rh KIDD

Front 39

What is the deferral for Hepatitis B IgG administration?

Back 39

12 months

Front 40

What are the protein antigens?

Back 40

Rh (D)
KIDD
KELL
S/s
Duffy

Front 41

What antigens must an individual be positive for if they are f antigen positive?

Back 41

c and e in the cis position

Front 42

What effect do thiol reagents (DTT,ZZAP) and enzymes have on Kell system antigens?

Back 42

Kell system ags are destroyed by thiol reagents (DTT,ZZAP) but untouched by enzymes alone.

Front 43

What is the acceptable temperature range for the transport of red blood cells?

Back 43

1-10C for 24 hours

Front 44

if a patient is C,D and e antigen positive (negative for c and E antigen), what is their most probable Rh genotype?

Back 44

R1R1

Front 45

McLeod phenotype

Back 45

In the Kell blood group, what phenotype is associated with all this: absence of Kx, markedly decreased Kell system ags, lack of anti-Ku, hemolytic anemia with acanthocytes, and association with X-linked CGD?
ACANTHOCYES and X-LINKED CHRONIC GRANULOMATOUS DISEASE)

Front 46

Saliva neutralizes:

Back 46

H, Le a

Front 47

Hydatid cyst fluid and pigeon egges neutralize:

Back 47

P1

Front 48

Breast milk neutralizes

Back 48

I

Front 49

What is the formula for calculating RhIg administration?

Back 49

Vials of RhIg=(maternal whole blood mL)X (% fetal cells in moms blood)/ 30

Front 50

Rh null (Bombay phenotype) is associated with :

Back 50

Hereditary stomatocytosis

Front 51

Anti-P is associated with:

Back 51

Paroxysmal cold hemaglobinuria (PCH) and syphilis.

Front 52

What is th eshelf-life for sline washed, thawed, or deglycerolized RBC's?

Back 52

24 hours

Front 53

Thawed FFP has a shelf life of:

Back 53

24 hours

Front 54

Thawed plasma has a shelf life of:

Back 54

5 days

Front 55

Pooled platelets have a shelf life of:

Back 55

4 hours

Front 56

What are the 4 most common antibodies that cause dlayed HTR?

Back 56

JKa
E
D
C

Front 57

Mixed field reactions are expected with :

Back 57

Lutheran
Sid
A3
post BMT

Front 58

Intravascular hemolysis is caused by:

Back 58

ABO
Kidd
P

Front 59

The presence of which antibody is implicated in spontaneous abortions?

Back 59

Anti P1 and and PP1-Pk

Front 60

Which antigens show dosage?

Back 60

Kidd (Jk)
Duffy (Fy)
Rh (DCE)
MNS

Front 61

Where are class I HLA antigens found?

Back 61

all nucleated cells and platelets

Front 62

Where are class II HLA antigens found?

Back 62

1) B cells
2) macrophages
3) activated Tcells

Front 63

Class I genes are found at what LOCI?

Back 63

HLA-A
HLA-B
HLA-C

Front 64

Class II genes are found at what LOCI?

Back 64

HLA-DR
HLA-DP
HLA-DQ

Front 65

Application of a tattoo has a deferral of:

Back 65

12 months

Front 66

What are clinical differences between a vasovagal vs a hypovolumic reaction?

Back 66

VASOVAGAL = decreased heart rate
hypotension
syncope
nausea

Hypovolumic has hepretension

Front 67

Bein incarcerated for more than 72 hours requires a deferral of:

Back 67

12 months