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18 Cards in this Set

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4 rbc metabolic pathways are:
anaerobic glycolytic pway
pentose phosphate
methemoglobin reductase pway
Luebering Rapoport shunt pway
rbc eat...
if disabled can cause heinze bodies...
NADH, NADPH...
ACCUMULATION OF 2,3 DPG
2,3 DIPHOSPOGLYCERATE LIES IN ITS PROFOUND EFFECT ON THE AFFINITY FOR
OXYGEN
BREATHE...
WHEN PENTOSE PHOSPHATE PWAY IS DEFICIENT, THE RESULT IS_______GLOBIN DENATURATION, PRECIPITATION AS AGGREGATES IN THE RBC
HEINZ BODIES
LUEBERING RAPOPORT SHUNT PWAY PERMITS THE ACCUMLATION OF ______
2,3 DPG
__ # METHEMOGLOBIN REDUCTASE PWAY ARE NEEDED TO MAINTAIN HGB IN A _____ FUNCTIONAL STATE.
REDUCED
___________, COUPLES OXIDATIVE METABOLISM W/ PYRIDINE NUCLEOTIDE AND GLUTATHIONE REDUCTION. INCR ACTIVITY OF THIS PWAY IS A RESULT OF RETARDATION OF GLYCOLYTIC PWAY AND AN ICREASE OF OXIDATION OF GLUTATHIONE
PENTOSE PHOSPHATE
10 % OF RBC'S ATP IS PROVIDED BY _______ PWAY
PENTOSE PHOSPHATE
90% OF ATP NEEDED BY RBC IS GENERATED BY THE ________ PWY, THE RBC MAIN METABOLIC PWAY.
GLYCOLYSIS
ENERGY REQUIRED FOR ACTIVE TRANSPORT AND MAINTENANCE OF MEMBRANE ELECTROCHEMICAL GRADIENTS IS PROVIDED BY
ADENOSINE TRIPHOSPHATE ATP
PASSIVE INFLUX OF NA AND K IS CONTROLLED BY OVER 300 CATIONIC PUMPS, WHICH TRANSPORT ____ OUT OF CELL AND ____ INTO CELL
NA OUT
K IN
THROUGH THE CONTROL OF ___ AND ____ RBC'S MAINTAIN ITS VOLUME AND H2O HOMEOSTASIS
K AND NA
RBC MEMBRANE IS FREELY PERMEABLE TO ___ AND ____ AND ____
H2O CL HCO3
THE LOSS OF RBC MEMBRANE IS EXEMPLIFIED BY THE FORMATION OF ------
SPHEROCYTES AND BITE CELLS
CELL MORPHOLOGY
INCREASE IN ____ CAUSES RBC MEMBRANE RIGIDITY AND LOSS OF PLIABILITY
CA
______ THE MAIN LIPID COMPONENET OF THE RBC MEMBRANE
PHOSPHOLIPID
THE LOSS OF ----- LEVELS LEADS TO DECREASED PHOSPHORLYATION OF SPECTRIN AND IN TURM LOSS OF MEMBRANE DEFORMABILITY
ATP
ENERGY
2 TYPES OF METHEMOGLOBIN
NADH NADPH
PREFERRED PWAY______, IS NECESSARY TO MAINTAIN _____ OF HGB IN THE FERROUS FUNCTIONAL STATE
METHEMOGLOBIN REDUCTACE PWAY,HEME IRON