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42 Cards in this Set

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  • Back
What drug causes Hemorrhagic cystitis?
Cyclophosphamide
Antidote to an "overdose" of Cyclophosphamide?
hydration, Mesna, NAC
Carmustine treats what?
Brain Tumors
common adverse effects in anticancer drugs?
NV, BMD, mucositis, stomatitis
Drug used in the treatment of bladder, ovarian, and testicular cancer
Cisplatin
In order to improve efficacy of Cisplatan what should you do?
Chloride diuresis
Cisplatan "overdose" antidote?
amifostine
MOA of Methotrexate?
Folate inhibitor
Methotrexate used to treat?
Lymphoma, leukemia, breast CA, Psoriasis, RA
used in the "overdose" of Methotrexate?
Leucovorin Rescue
5-Fluorouracil used to treat?
Basal cell carcinoma
breast cancer
colorectal CA
Cytarabine (ara-C) must be converted to active form. What other anticancer drug is a prodrug?
cyclophosphamide
6-Mercaptopurine used to treat?
ALL, AML, CML
Vincristine used to treat?
Lymphocytic leukemia
Vincristine tox?
Vinblastine tox?
CNS
myelodepression
Etoposide MOA
inhibits Topoisomerase II
Topotecan MOA
inhibits topoisomerase I
Dactinomycin adverse effects?
Proctitis
Causes Cardiotoxicity
Doxrubicin
Daunorubicin
L-asparginase used to treat?
ALL
L-asparginase can cause what if infused rapidly?
Anaphylaxis

also causes pancreatitis and coagulopathy
Tamoxifen used to treat?
ER (+) Breast CA
Anastrozole treats?
mets ER (+) and PR (+) tumors
Bortezomib treats?
Multiple Myeloma
Imatinib treats?
CML
Trastuzumab treats?
Breast CA ER (-) but HER-2 receptor (+)
What drug blocks VEGF?
Bevacizumab
Adverse Effect is Osteoporosis with long term use
Prednisone
what protein plays a role in multidrug resistance anticancer drugs
p-glycoprotein= efflux pump
what drugs Tx acute rejection episodes?
Prednisone, ALG, muromunab-CD3, Daclizumab, Basiliximab
This drug causes cytokine storm in a transplant patient
Muromunab-CD3 (OKT3)
Repeated treatments of OKT3 contraindicated why?
Abs will form against OKT3
What drug do you need to be careful with in transplant patients when dosing with allopurinol?
Azothioprine
What drug inhibits calcineurin?
Cyclosporine
Most common tox of cyclosporine?
Nephrotox
What drug causes gingival hyperplasia and hirsutism?
cyclosporine
What immunosupressive drug has good antiinflammatory properties?
Azathioprine
What drugs Treat Psoriasis, RA, and GVHD?
Cyclosporine and Methotrexate.
What drug is an IL-2 antagonist
Daclizumab and Basiliximab
Prednisone has immunosupressive properties and used for what other Tx?
Autoimmune Dz
major risk factors for immunosuppressive therapy?
infection and malignancy
Bleomycin uniqueness
doesn't suppress BM so can be a good combo drug and causes radical testicular cancer cure