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11 Cards in this Set
- Front
- Back
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How can we limit the toxicity of Cyclophosphamide?
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Hydrate
Mesna N-acetylcysteine |
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Whats the Dose-Limiting toxicity of Bleomycin?
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pulm. tox. (significant b/c the dose-limiting toxicity is NOT Bone marrow depression)
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Whats the Dose-Limiting toxicity of Nitrosoureas?
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CNS, Renal, Hepatic, Pulm (significant b/c the dose-limiting toxicity is NOT Bone marrow depression)
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Whats the Dose-Limiting toxicity of Vincristine?
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Neurological (significant b/c the dose-limiting toxicity is NOT Bone marrow depression)
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What are some of the drugs that require metabolic activation in order to become neoplastic?
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Cyclophosphamide
6-Mercaptopurine (activated by HGPRT) 6-Thioguanine (activated by HGPRT) |
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Why is Leucovorin used in conjunction with anti-cancer therapy?
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Reduces toxicity from DHFR inhibition in normal cells (BM, GI)
Used with Methotraxate |
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What is used with methotrexate to reduce its toxicity?
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Leucovorin
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Why is Allopurinol used in conjunction with anti-cancer therapy?
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Inhibits Xanthine Oxidase
Used with 6-Mercaptopurine (note: the dose of 6-Mercaptopurine must be lowered when given with Allopurinol) |
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Why is Mesna used in conjunction with anti-cancer therapy?
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Neutralizes the toxicity of acrolein, a metabolite of cyclophosphamide
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Why is N-acetylcysteine used in conjunction with anti-cancer therapy?
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Limits toxicity (vs. Mesna, which NEUTRALIZES toxicity...) of Cyclophosphamide by neutralizing acrolein, a metabolite of cyclophosphamide
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Why is Amifostine used in conjunction with anti-cancer therapy?
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Cyto-protective agent (=protects cells)
Used with Cisplatin. Amophostine is metabolized to release a thiol metabolite which acts as a scavenger |
