Block 5 Clinical Systems Hemoncology

Front 1

If a patient has an ANC<500 and a fever, what should you do?

Back 1

Admit the patient to the hospital if he has an absolute neutrophil count of what value combined with what other symptom?

Front 2

Describe a Reed-Steinberg Cell and what disease is it associated with?

Back 2

Lots of multinucleated cells with bilobed nuclei are associated with Hodgkins Disease. What are these cells called?

Front 3

What is the treatment for Hodgkins lymphoma?

Back 3

Radiation therapy or AVBD chemotherapy are the treatments for what disease?

Front 4

What is the most common leukemia?

Back 4

Chronic Lymphocytic Leukemia is the most common what?

Front 5

Your patient presents with complaints of lethargy, fatigue, and intermittent burning or throbbing at the extremeties. Upon physical exam, you note reddened face, palms, and soles of feet. What is your diagnosis?

Back 5

Polycythemia Rubra Vera presents with what symptoms?

Front 6

When should you treat Polycythemia Rubra Vera? With what?

Back 6

What condition is treated with Hydroxyurea or Phlebotomy (to develop Fe deficiency) once hyperviscosity has developed?

Front 7

If your patient has particulary heavy periods, what may be the cause?

Back 7

Von Willebrand's disease often goes undiagnosed because the symptoms are minor. What is an example?

Front 8

A decreasing platelet count with decreasing fibrinogen levels, and a peripheral smear with fragments present, is indicative of what condition?

Back 8

DIC will show what type of labs and smear?

Front 9

If your patient has particulary heavy periods, what may be the cause?

Back 9

Von Willebrand's disease often goes undiagnosed because the symptoms are minor. What is an example?

Front 10

A decreasing platelet count with decreasing fibrinogen levels, and a peripheral smear with fragments present, is indicative of what condition?

Back 10

DIC will show what type of labs and smear?

Front 11

What is the classic clinical triad associated with Henoch-Schonlein Purpura?

Back 11

Arthritis, abdominal pain, and purpura together are associated with what condition?

Front 12

What is the treatment for Henoch-Schonlein Purpura?

Back 12

The treatment of what condition is supportive, with NSAIDS for arthritis?

Front 13

What is the most common type of thrombocytopenia?

Back 13

Increased destruction is the most common cause of what?

Front 14

What is the most common cause of drug-induced TTP?

Back 14

Heparin is the most common cause of what?

Front 15

Do NOT transfuse platelets for which conditions?

Back 15

ITP, TTP, HITT patients should not receive what treatment?

Front 16

Which conditions have a very few number of large platelets that are overworking?

Back 16

HUS
TTP
HELLP
DIC

What's the big picture with these guys in terms of platelets?

Front 17

Your patient presents with fever, headache, paralysis, thrombocytopenia. What do you diagnose?

Back 17

TTP has what major symptoms?

Front 18

If you have low Factor 8, then you also have low what?

Back 18

If you have low VonWillebrand's Factor, then you also have low what?

Front 19

What is Virchow's Triad?

Back 19

Hypercoaguability
Stasis of Flow
Endothelial Damage

What is this?

Front 20

Your patient is pale and complains of SOB on exertion with occasional chest pain. Her heart palpitates. She's been eating strange things lately. What do you suspect?

Back 20

How would a patient with anemia present?

Front 21

A high reticulocyte count indicates what conditions?

Back 21

Hyperproliferative Anemias have what lab value?

Front 22

An MCV of less than 80 suggests what type of anemia?

Back 22

Microcytic anemia is associated with Fe deficiency and shows what lab value?

Front 23

Major Beta Thallasemia is associated with what characteristics?

Back 23

Retarded growth, multiple organ dysfunction, premature death, and increased jaw formation are associated with what condition?

Front 24

What is the main problem in thalassemia?

Back 24

Reduced rate of production of Hemoglobin is also known as?

Front 25

What type of anemia is caused by B12 deficiency?

Back 25

Megaloblastic anemia is caused by what?

Front 26

Chronic pancreatitis can cause what type of anemia?

Back 26

Macrocytic anemia can cause what?

Front 27

What are the indications for RBC transfusion?

Back 27

Massive Bleeding
Cardiopulmonary Compromise
Need to increase Hematopoesis
Complicated Hemoglobinopathies

What do you do?

Front 28

What is TRALI?

Back 28

Transfusion related acute lung injury...

Front 29

Define Adenoma.

Back 29

Benign tumor of the glands.

Front 30

Define Carcinoma.

Back 30

Cancer of epithelial origin.

Front 31

Define Sarcoma.

Back 31

Mesenchymal tumors of CT or blood.

Front 32

Define Metaplasia.

Back 32

Replacement of normal epithelium with another in an unusual location. Reversible.

Front 33

Define Dysplasia.

Back 33

Disordered growth and differentiation of epithelium. Reversible.

Front 34

EBV is associated with what type of cancer?

Back 34

Burkitt's lymphoma is associated with what infection?

Front 35

Define Sensitivity.

Back 35

Liklihood of a positive test result in a person with the disease.

Front 36

Define Specificity.

Back 36

Likelihood of a negative test result in a person without the disease.

Front 37

Define Positive Predictive Value.

Back 37

Likelihood that a person with a positive test result has the disease.

Front 38

Define Negative Predictive Value.

Back 38

Liklihood that a person with a negative test result does not have the disease.

Front 39

Explain Gompertzian Growth.

Back 39

As tumors get bigger the growth rate and doubling time slows.

Front 40

Activation of caspase enzymes will cause what?

Back 40

Apoptosis is induced by what?

Front 41

Cytochrome C
Mitochondrial pathways
p53
Caspase 8 gene

What are these guys associated with?

Back 41

Apoptosis is the result of activation of what genes?

Front 42

Describe acute tumor lysis syndrome.

Back 42

Inc Uric Acid, K, P, Ca, and decreased urine output are signs of what?

Front 43

What is the most common cause of SVC syndrome?

Back 43

Obstruction of the superior vena cava is the most common cause of what?

Front 44

Hypercalcemia is associated with what types of cancer?

Back 44

Multiple Myeloma and Breast cancer commonly present with increased what?

Front 45

What organisms are of the most concern with Neutropenic fever?

Back 45

Gram negs like Enterobacteriacae and Pseudomonas are rapidly fatal in what condition?

Front 46

What's wrong in multiple myeloma?

Back 46

Uncontrolled proliferation of IgG and IgA secreting plasma cells is associated with what condition?