Block 4 Micro Immuno Exam

Front 1

Patient presents with painful papules that have ulcerated necrotic centers, lymphadenopathy, bacteremia, and a history of tick bite. What is the most likely pathogen?

Back 1

Francisela tularensis causes what major symptoms?

Front 2

What is the pathogen in tularemia?

Back 2

Francisela tularensis causes a condition known by what name?

Front 3

What is the major virulence factor of Francisela tularensis?

Back 3

A polysaccharide rich capsule is the major virulence factor of which aerobic parasite?

Front 4

What is the infectious form of Toxoplasma gondii? What is the definitive host? Where are oocytes found?

Back 4

The tachyzoite is the slender infectious form of what pathogen whose oocytes are found in definitive host's (cat) feces?

Front 5

Toxoplasmosis is caused by what pathogen?

Back 5

Toxoplasma gondii causes what disease?

Front 6

An infant is born with encephalitis and epilepsy. The mother presents with jaundice and anemia. What pathogen is likely to have caused the symptoms?

Back 6

Toxoplasma gondii can cause what symptoms in mother's and their infants?

Front 7

Brucella melitensis is often transmitted through what mode?

Back 7

Drinking contaminated milk is the most common way to become infected with what organism?

Front 8

The O antigen of LPS is the major virulence factor of which pathogen?

Back 8

Brucella melitensis has what major virulence factor?

Front 9

How do colonies of Brucella melitensis appear?

Back 9

What pathogen has slow growth on special media? The more virulent form appears smooth, translucent, homogenous. The less virulent form is rough, opaque, granular, sticky.

Front 10

The acidic environment in a phagolysosome induces the virulence factor of what pathogen?

Back 10

Brucella melitensis replicates in the cytoplasm after lysis of the phagolysosome. What initiates this process?

Front 11

Leishmania donovani is transmitted by what vector?

Back 11

The sandfly is the vector for what condition?

Front 12

Leishmaniasis presents with what major symptoms?

Back 12

Patient presents with a swollen face, protruding abdomen, low-grade fever, sob, and diarrhea. He is anemic and his mucous membranes are bleeding. What do you suspect?

Front 13

The human body louse is the vector for what pathogen?

Back 13

Rickettsia prowazekii is transmitted through what vector?

Front 14

A patient presents with high fever, headache, a maculopapular rash, HT and enlarged spleen. What pathogen do you suspect?

Back 14

Rickettsia prowazekii presents with what major symptoms?

Front 15

The chigger (mite larvae) is the vector for what pathogen?

Back 15

Rickettsia tsutsugamasti is transmitted through what vector?

Front 16

Scrub typhus is caused by what organism?

Back 16

Rickettsia tsutsugamasti causes what disease?

Front 17

Patient presents with fever, headache, maculopapular rash, enlarged spleen, delerium, and muscle twitching. What is the most likely pathogen?

Back 17

Rickettsia tsutsugamasti causes what major symptoms?

Front 18

Chronic infections will cause what type of anemia?

Back 18

Normocytic/Normochromic
Microcytic/Hyporchromic

Anemias caused by what type of infections?

Front 19

What do the Fe levels look like in a patient with anemia from chronic infections?

Back 19

Dec. Serum Fe
Dec. Transferrin
Norm/Inc Fe stores

These levels are seen in a patient with what type of anemia?

Front 20

Cytokines will _____ hepcidin, which has what function?

Back 20

What substance decreases erythropoetin and hematopoiesis (RBC prod) in bone marrow?

Front 21

What is the function of Hepcidin?

Back 21

Regulation of Fe metabolism
Absorbtion of Fe from food
Release of Fe from macrophages
Recycling of RBC's

These are the responsibilities of what substance?

Front 22

What substance is responsible for transport of Fe across the placenta?

Back 22

Hepcidin has what role in neonatal Fe absorbtion?

Front 23

During inflammation, hepcidin production ______, which has what effect?

Back 23

Increased hepcidin production causes increased sequestration of Fe in macrophages. When is this most likely to occur?

Front 24

What is the gold standard for diagnosis of malaria?

Back 24

In comparison to other diagnostic methods, where does identification of plasmodium by microscopy rank?

Front 25

Plasmodium vivax has what characteristic feature on microscopy?

Back 25

Small purplish red granules on microscopy of Wright's stained specimen is characteristic of what pathogen?

Front 26

Merozoites adhere to glycoprotein on RBC cell membrane, which then becomes rigid and adherant, in what pathogen?

Back 26

Plasmodium falciparum is the most severe form of malaria due to what pathogenic feature?

Front 27

Which form of malaria has a dormant phase in the liver which allows replication without RBC's as well as frequent relapses?

Back 27

Plasmodium vivax/ovale frequently relapse due to what feature?

Front 28

Babesioses is transmitted through which vector?

Back 28

What pathogen can be transmitted through both the deer tick and the white footed mouse?

Front 29

Babesiosis has what characteristic feature on microscopy?

Back 29

What pathogen displays tetrads in a direct blood smear?

Front 30

A patient goes into shock after a few bouts with hemolytic anemia, hemoglobinuria, and fever. What do you suspect?

Back 30

Babesiosis has what major symptoms?

Front 31

Bartonella bacilliformis is transmitted by what vector in the Andes?

Back 31

The nocturnal sandfly is the vector for what organism? Where is it commonly found?

Front 32

Oroya fever is caused by what organism?

Back 32

Bartonella bacilliformis causes what condition?

Front 33

What is the virulence of Bartonella bacilliformis?

Back 33

What pathogen hides in the RBC to avoid presentation by MHC molecules?

Front 34

Gangrene is caused by what pathogen?

Back 34

Clostridium Perfrinogens causes what condition?

Front 35

Which virulence factor of clostridium perfrinogens causes increased vascular permeability, hemolysis, and platelet destruction?

Back 35

What is caused by alpha-toxin and what pathogen is it associated with?

Front 36

Which virulence factor of clostridium perfrinogens disrupts the membranes of erythrocytes, leukocytes, and muscle cells?

Back 36

Lecithinase reacts with RBC's to produce lysolecithin, which has what effect? What pathogen is it associated with?

Front 37

Which virulence factor of clostridium perfrinogens forms pores which cause loss of cellular fluid and alter capillary permeability? It is also toxic to heart muscle and heat and oxygen labile.

Back 37

Theta toxin is a hemolysin associated with which pathogen? What effects does it have?

Front 38

Which virulence factor of clostridium perfrinogens causes initial cell death in respiratory tract and RBC's?

Back 38

H2O2 Production is a virulence factor of what pathogen? What function does it have?

Front 39

Kinetoplastids are associated with what organism?

Back 39

Trypanosoma brucei gambiense or rhodesiense has what characteristic feature under the microscope?

Front 40

Human African Sleeping Sickness is caused by what pathogen?

Back 40

Trypanosoma brucei gambiense or rhodesiense causes what condition?

Front 41

What is the vector for Trypanosoma cruzi?

Back 41

Reduvid kissing bugs are the vector for what pathogen?

Front 42

Patient presents with a swollen shut eye, fever, fatigue, hepatosplenomegaly after travel in South America. What pathogen do you suspect?

Back 42

Trypanosoma cruzi presents with what major symptoms?

Front 43

Filariasis is caused by what organisms most commonly?

Back 43

Wucheria bancrofti and Brugia malayi cause what condition?

Front 44

Onchocerca volvulus is a pathogen that causes filariasis with what special finding?

Back 44

Eye issues are associated with what filariasis causing organism?

Front 45

What would the labs show in a patient with filariasis?

Back 45

Marked eosinophilia is present in patients with filariasis. True or false?

Front 46

Megaloblastic anemia can be caused by which organism that competes for Vit B12?

Back 46

Dyphillobothrium latium is a fish tapeworm that causes what type of anemia? Why?

Front 47

Mycoplasm pneumonia has what mechanism of resistance to penicillins (b-lactams)?

Back 47

What organism is resistant to penicillin (b-lactams) because it lacks a cell wall?

Front 48

Rubella can cause what blood related skin rash?

Back 48

Thrombocytopenic purapura can be caused by what virus?

Front 49

Helicobacter pylori has what activity to reduce pH of its environment?

Back 49

Urease activity reduces the pH of the environment of which pathogen?

Front 50

Enteric bacteria produce _____, which exposes normally hidden Ag's on RBC's.

Back 50

What is the function of neuraminidase?

Front 51

Hemophilus Influenzae type B meningitis is an example of a mismatched _______.

Back 51

Antigen/Ab complexes can mistakenly bind to RBC's when they are formed in response to what pathogen?

Front 52

Donath Landsteiner Antibodies cause what condition?

Back 52

IgG antibodies that cause paroxysmal cold hemoglobinuria are also known as what?