Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

30 Cards in this Set

  • Front
  • Back
What do all 1st generation anti-psychotics have in common?
All have the SAME EFFICACY
How long does anti-schizophrenic effect of drugs take to develop?
Several weeks (2-3)
When is the SE of oversedation most prominent?
When blood levels of drugs are initially built up

Decreases when anti-psychotic effect develops
What group of pts. is anti-psychotic OD a problem in?
Why are anti-psychotics contraindicated in epileptics?
They lower the seizure threshold

Only administered if given concomitantly w/ an anti-epileptic
How do anti-psychotics affect the heart?
Directly -- NEGATIVE inotropic effect ("Quinidine-like")

Indirectly -- tachycardia (due to alpha-1 blockade)
How do anti-cholinergic SEs of anti-psychotics compare w/ those of TCAs?
LESS severe
How do anti-psychotics cause galactorrhea, amenorrhea, etc.?
Decreased DA --> Increased prolactin
How do you treat neuroleptic malignant syndrome?

What drugs could you use?
Withdrawal of all drugs

I.V. dantrole, oral bromocriptine
What are some signs/symptoms of neuroleptic malignant syndrome (4)?
Muscle rigidity
Autonomic signs
Altered consciousness
In terms of receptor action, how are 2nd gen anti-psychotics different?
Weaker DA blockade
STRONG 5-HT2 blockade
What are the main side effects of 2nd gen anti-psychotics (3)?
Weight gain
Induction/exacerbation of Type II Diabetes
Sleep apnea
What receptor action does chlorpromazine have (5)?
Potent D2 antagonism

Alpha-1 antagonism
Muscarinic antagonism
Histaminic antagonism
Non-competitive channel blocker (cardiac effects)
How long does it take for chlorpromazine's effects?
2-3 weeks to develop

4-6 months to stabilize
What potency caterogy does chlorpromazine fall in?
Low potency
What brain structures does chlorpromazine target?
Frontal cortex
Limbic system
What are the EARLY neuroleptic symptoms of chlorpromazine (3)?

How can they be treated?
Parkinson-like symptoms, akathisia, acute dystonia

Treated w/ anti-cholinergics, anti-parkinson drugs
Diphenhydramine, trihexiphenidyl, benztropine
What is a very serious potential late side effect of chlorpromazine?
Tardive dyskinesia

Irreversible and untreatable
Occurs in 20% of schizo in-patients
What category (potency) does Thioridazine fall in?
Low potency
What, generally, is the side-effect profile of thioridazine?
MAJOR anti-cholinergic/adrenergic effects

What category (potency) do fluphenazine, and haloperidol fall into?
High potency
What side effects are low potency anti-psychotics more apt to cause?
More anti-cholinergic effects
More autonomic dysfunction
More sedation
What side effects are high potency anti-psychotics more apt to cause?
More EPS
What is clozapine mainly used for?
Therapy of pts. who are refractive to all other options
What is a mjor side effect of clozapine that limits its use?
Fatal agranulocytosis (2-3%)
What must be done while a pt. is on clozapine?
Weekly WBC counts
How does smoking effect olanzapine?
Decreases its blood levels
What is a major benefit of olanzapine over clozapine?
No risk of agranulocytosis
What side effect is more prominent in risperidone?
(vs. other atypical anti-psychotics)
More sedation
Which is more efficacious against drug-induced psychosis in late PD?

Olanzapine or Clozapine