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7 Cards in this Set
- Front
- Back
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What type of drug is Donezepil?
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AChE inhibitor
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How does Donezepil affect the course of AD?
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Does NOT alter the course of AD
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What two main types of drugs are employed in AD?
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AChE inhibitors
NMDA-receptor antagonists |
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What type of drug is Memantine?
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NMDA-receptor antagonist
(low-moderate affinity, NON-competitive inhibitor) |
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How does Memantine affect AD?
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Shown to improve symptoms
Shown to reduce the rate of deterioation (in moderate-severe AD) |
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What are secretases?
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Enzymes that cleave amyloid precursor protein
(could play a rold in plaque aggregration) |
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How do NSAIDs affect AD?
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Thought to offer modest prophylaxis via down-regulation of gamma-secretase
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