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45 Cards in this Set

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Respiratory tract is bathed in this to prevent infection
IgA

Particularly effective against influenza
Non-obvious viruses that enter via respiratory tract
Adenoviruses
Hantaviruses (part of Bunya)
Herpesviruses
B19 parvovirus
Virus family of Poliovirus
Picornaviridae
Virus family of coxsackie viruses
Picornaviridae
Enveloped virus that infects GI tract
Enteric coronavirus

Remember, RARE for enveloped viruses to infect GI tract
Viruses that can enter via GI tract
Picornaviruses
Rotavirus
Astroviruses
Caliciviridae
Adenoviruses
Coronaviruses
Reovirus
Virus family of Norwalk virus
Caliciviridae
Enteric adenoviruses and Norwalk viruses infect these cells
Intestinal epithelial cells
Astroviruses infect these cells
M cells
4 main protections for GI tract
Alkaline pH
Enzymes & bile
IgA (mucosal immunity)
Motion
Viruses that enter through the skin
Poxviruses
Herpes simplex
Adenoviruses
Rhinoviruses
Rabies virus
Virus family for rabies virus
Rhabdoviridae

Also includes Vesiculovirus
This virus can infect olfactory receptor cells
Rabies virus
These viruses can enter conjuctiva & sclera
Herpes simplex
Adenoviruses
Some picornaviruses
How does polio virus spread
Hematogenously
Where does measles initially replicate
Respiratory epithelium
These viruses spread in blood as free viruses
Polio virus
Yellow fever virus
Hepatitis B virus
What cell type is EBV assoc. w/ when blood borne?
B Cells
These viruses replicate in Kupffer cells
Hepatitis A
Hepatitis B
Dengue and Rubella assoc. w/ this type of cell in blood
Monocyte/Macrophage
Virus family of RSV
Paramyxoviridae

Also contains measles and mumps
Viruses for which immune system contributes to damage
Hepatitis B
Dengue virus
RSV
Virus family for Dengue virus
Flaviviridae
Viruses in which pts. with Ab have worse disease
Dengue virus
Virus in which immunized children were found to be worse off
RSV
Response generated by KILLED vaccines
Strong Ab response
Weak cell-mediated response

Vaccine is effective for hematogenously spreading virus
Type of vaccine for polio
Killed (Salk) or live attenuated (Sabin)
Type of vaccine for MMR
Live attenuated
Type of vaccine for chicken pox
Live attenuated
Type of vaccine for Hepatitis A
Killed
Type of vaccine for Hepatitis B
Subunit
Type of vaccine for influenza
Killed
Type of vaccine for rabies
Killed
Types of vaccines for the encephalitides
Killed
Viruses with live attenuated vaccines
MMR
Varicella (chicken pox)
Yellow fever
Adenovirus
Why do live attenuated vaccines lose human virulence
Accumulation of mutations
Type of response live attenuated vaccines induce
Strong cell-mediated immunity
Moderate Ab response

Typically, produce longer lasting immunity
Two main risks of live attenuated vaccines
Reversion to wild type (rare)
Causing disease in immunosuppressed
Type of vaccine for smallpox
LIVE (Vaccinia)

Vaccinia is used in novel, recombinant vaccines
Target for Acyclovir
Herpes simplex DNA polymerase
Target for AZT
HIV RT
Target for Ribavirin
RNA-dependent RNA polymerase of RSV
Target for Zanamivir/Oseltavir
Neuraminidase of invluenza virus
Strain(s) of flu Amantadine/Rimantadine work for
Strain A only
Strain(s) of flu Zanamavir/Oseltamivir work for
BOTH strains A and B