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34 Cards in this Set

  • Front
  • Back
The two genera of papovaviruses
Polyomaviruses
Papillomaviruses
Charactertistic features of papovavirus genome
dsDNA
Circular
Associated with HISTONES

Can exist as free or integrated
The two capsid proteins in HPV
L1
L2
HPV types found in SKIN warts
HPV 1 - 4
HPV types found in GENITAL warts
HPV 6 - 11
Routes of HPV transmission
Direct, skin-skin contact
Sexual contact
HPV types associated with cancer
HPV 16, 18, 31, 33
Is DNA polym. that is used for papillomavirus replication:

Host or viral encoded?
HOST encoded DNA dependent DNA polymerase
Where do papillomaviruses undergo replication?
Exclusively in nucleus
What is papillomavirus growth linked to?
Epithelial cell differentiation

DNA is synthesized in basal skin cells
Virus grows in uppermost layers
Cell transformation uses which papillomavirus proteins
E6 and E7
E6 interacts with what host cell protein
p53
E7 interacts with what host cell protein
Rb
What DNA event is important for malignant progression?
Integration into the host genome
In a "simply" infected (ie. non-transformed) cell, how is the viral DNA?
Episomal
Hallmark of HPV infection
Koilocytosis

Squamous epithelial cells have cytoplasmic vacuoles
What HPV protein is being used in a vaccine?
L1
How long does it take to develop anti-L1 Ab in a genital HPV infection?
8 - 16 months
(image in notes)
Treatment for skin warts
Liquid nitrogen
Treatment for genital warts
Podophyllin
Alpha-interferon (for recurrent infections)
Merck's Gardasil vaccine protects against which HPV types?
6, 11, 16, 18

These cause 90% of genital warts
GSK's Cervarix vaccine protects against which HPV types?
16, 18
Two types of polyomaviruses
JC
BK
Where do polyomaviruses setup latent infections?
In the KIDNEY
% of adults that are seropositive for polyomavirus infections
60 - 80%
When does polyomavirus reactivation occur?
In transplant recipients as a result of immune suppression

Generally, results in graft loss
From where was JC isolated?
Brain tissue of pt. w/ progressive multifocal leukoencephalopathy
From where was BK isolated?
Urine of a kidney pt. on immunosuppressive therapy
How are polymoviruses shed?
In urine (10-60% post-transplant pts.)
Smallest icosahedral viruses
Parvoviruses
Complications of intrauterine B19 parvovirus infection
Hydrops fetalis
Fetal death
Complications of parvovirus infection in pts. w/ underlying hematologic problem?
Aplastic Anemia
What is the etiologic agent of Fifth's disease?
B19 parvovirus

NOTE: Fifth's is a.k.a. erythema infectiosum
Hydrops fetalis
Fetal organs fail
Large amounts of fluid build up in fetal tissues & organs