Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

24 Cards in this Set

  • Front
  • Back
Neuraminidase action to subvert host defense
Cleaves mucus carbohydrate
Allows binding in respiratory tract
TLR3 can trigger a response based on recognition of what?
ds RNA
TLR8 can trigger a response based on recognition of what?
ss RNA
TLR9 can trigger a response based on recognition of what?
Microbial DNA
Where are TLR3, 8, and 9 located?
Within lumen of endocytic vesicles
Surfactant A and D are part of what family?
Collectins are produced where?
Cells of respiratory tract
Engagement of TLR3, 8, 9 results in activation of?
Other regulatory factors
dsRNA production activates what host defense entities?
Cytosolic protein kinase PKR
Cytosolic 2,5 Adenylate Synthesis

Ultimately, NF-kappaB is activated
Role of Influenza NS1 protein
Sequesters dsRNA
Prevents PKR and 2,5 AS activation
Subversion of intracellular dsRNA detecting system

Sequestration of dsRNA
Inactivation/inhibition of PKR activation
Engagement of IFNR results in what?
Activated STAT1, which signals expression of anti-viral products
Ex. PKR and 2,5 AS
What type of viruses can subvert pro-inflammatory (STAT1) response?
Large DNA viruses

Decoy receptors
Inactive cytokine homologs
Intracellular inhibitors of IFNR/STAT1 pathway
How does activation of NF-kappaB induce apoptosis
Stabilizing expression of p53
Upregulating PKR (over-expressing)
Humans deficient in NK cells are more susceptible to which virus family?
How many days does it take for T cell response to be mounted?
5 - 7 days
NK cells monitor body cells for expression of what?
MHC Class I molecules
What is cross-presentation by APCs?
APCs presenting viral peptides from phagocytosed cells
Cytosolic Proteosome Protease Complex
Fragments viral peptides in the cytoplasm
TAP transporter complex
Transports viral peptides to the ER
Where are viral peptides bound to nascent MHC molecules?
In the ER
Herpesvirus strategies for subverting Ag presentation
Block proteosome function
Block TAP transporter
Retain MHC/peptide complexes in ER/Golgi
Promote degradation of MHC molecules

Ultimately, display of MHC/peptide complex is prevented
How does CMV evade NK cell-mediated killing?
Produces an MHC Class I homolog
Vaccination for this virus in children proved disastrous