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60 Cards in this Set

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Aminoglutethimide is used for the treatment of
Cushing's Syndrome
Adrenal Hyperplasia
Adrenal Cancer

are treated with what?
What is the MOA of spironolactone?
Inhibits the MC effect on the renal tubule to increase Na and Cl excretion, thereby decreasing BP.
Side effects of Corticosteroid Antagonists
Fatigue/Lethargy
Drowsiness
Nausea
Vomiting

are side effects of what meds?
People who have

Diabetes
Peptic Ulcer
Osteoporosis
Infection
Pregnant

should not use what?
List the contraindications of Corticosteroids.
Prednisone is contraindicated in patients with what condition?
Liver dysfunction is a contraindication of what corticosteroid?
Prednisone is used in the treatment of
Myasthenia Gravis
Adrenal Insufficiency/Cancer
Triamcinolone is special because it does what?
This corticosteroid does NOT suppress the HPA axis.
Dexamethozone is used to treat what conditions?
Addisonian Shock
Adrenal Insufficiency
Short Term for RA
Cushing's Dx
STRONGEST anti-inflammatory
Betamethazone is used to treat what conditions?
In topical form, this corticosteroid treats dermatoses.
Beclomethazone is used to treat what condition?
This corticosteroid is available as a NASAL inhalant to treat asthma.
Hydrocortizone
Short acting corticosteroid.
Prednisolone
Intermediate acting corticosteroid
Prednisone
Intermediate acting corticosteroid
Methylprednisone
Intermediate acting corticosteroid
Triamcinolone
Intermediate acting corticosteroid
Dexamethazone
Long acting corticosteroid
Betamethazone
Long acting corticosteroid
Beclomethazone
Long acting corticosteroid
Methylprednizone Acetate is used to treat what?
Intermediate acting corticosteroid for acute allergies
Methylprednizone Succinate is used for what?
This long acting corticosteroid is used for
emergencies (IV, PO, IM)
short term asthma
chronic and acute inflammation
List all the corticosteroids
Hydrocortizone
Methylprednizone Acetate
Methylprednizone Succinate
Prednisolone
Prednizone
Triamcinolone
Dexamethaxone
Betamethazone
Beclomethazone
List the corticosteroid antagonists
Spironolactone
Aminoglutethimide
Aminoglutethimide
Corticosteroid Antagonist
Spironolactone
Corticosteroid Antagonist
What does cortisol do?
(-) protein synthesis
(-) release of CRH and ACTH
(+) glucose formation
(+) fatty acid release
Aspirin
Cyclooxygenase Inhibitor
Ibuprofen
Cyclooxygenase Inhibitor
Indomethacin
Cyclooxygenase Inhibitor
Ketorolac
Cyclooxygenase Inhibitor
Naproxen
Cyclooxygenase Inhibitor
Piroxicam
Cyclooxygenase Inhibitor
Sulindac
Cyclooxygenase Inhibitor
Diclofenac
Cyclooxygenase Inhibitor
Name all the Cyclooxygenase Inhibitors
Aspirin
Ibuprofen
Indomethacin
Ketorolac
Naproxen
Piroxicam
Sulindac
Diclofenac
Celecoxib
Cyclooxygenase 2 Inhibitor
NSAID with reduced incidence of GI side effects
Celecoxib
MOA of Aspirin Acetylsalicylic Acid
Non-selective and irreversible inhibition of cyclooxygenase, and thus synthesis of prostaglandins and thromboxanes.
Additional MOA of Aspirin Acetylsalicylic Acid
Inhibit granulocyte adherance to vasculature
Stabilizes lysosomes
Inhibits chemotaxis of polymorphonuclear leukocytes and macrophages
Acetylsalicylic Acid is used prophylactically with what conditions?
Coronary Artery Disease
Deep Vein Thrombosis
Unstable Angina
Myocardial Infarction
Stroke

These can be prevented with
What is the drug of choice for antipyresis in children?
Acetominophen can be used for what condition in children?
Used as analgesic and anti-inflammatory in gout, RA, osteoarthritis.
Ibuprofen
Naproxen

What's the use?
Used as analgesic for osteoarthritis and musculoskeletal pain.
How is Diflusinal used?
Indomethacin is indicated in the
Treats
-RA
-Acute Gouty Arthritis
-Osteoarthritis
-Closure of PDA
Why is indomethacin so potent?
Rapidly and Completely absorbed from GI tract
Highly bound to plasma proteins
What allows Sulindac to have 1-2 daily doses?
Long half-life

prodrug metabolized in liver to sulfide metabolite
Dicolfenac is used for
Long-term treatment of osteoarthritis and ankylosing spondylitis.
Short-term treatment of acute musculoskeletal and postop pain
NSAID used for dysmenorrhea, OA, RA, postop pain
Celecoxib
Long-term treatment of RA, OA, and acute gout with once daily dosing.
Piroxicam
Meloxicam

used for....
Drugs displaced by NSAIDs on plasma proteins
Anticoagulents
Phenytoin
Sulfonamide
Sulfonylureas
Contraindications of NSAIDs
Third-trimester pregnancy
Comprised Renal Function
Concomitant Anticoagulants
Concomitant Corticosteroids
Side effects of COX-2 inhibitors
increased risk of thrombosis, stroke, MI
Side effects of NSAIDs
Gastric and intestinal ulcers
Diarrhea
Urticaria
Increased stomach acid secretion (d/t inhibition of prostaglandin synthesis)
What meds can be prescribed as co-therapy to reduce NSAID induced GI injury?
Misoprostol
High dose H2 Receptor Antagonist
Proton Pump Inhibitor
Gout is the accumulation of what in the synovial fluid?
Monosodium urate crystals accumulate in what condition?
Drug of choice for acute gout attacks
Indomethacin or Ibuprofen
Second drug of choice for acute gout attack
Naproxen and Diclofenac fall where in gout treatment?
Colchicine has what MOA in the treatment of gout?
Stops release of chemotactic factors, granulocyte migration, phagocyte activity, mast cell degranulation.

Duration of therapy limited by diarrhea, nausea, vomitting, bone marrow suppression. Acute only.
Allopurinol has what MOA in the treatment of gout?
Inhibits xanthine oxidase to reduce plasma uric acid levels. Chronic only, avoid in acute cases.
What is the active metabolite of allopurinol?
Oxypurinol is the active metabolite of what drug?
What is the MOA of probenicid in the treatment of gout?
Blocks proximal tubular reabsorbtion of uric acid to lower serum levels. Twice daily with lots of fluid.