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60 Cards in this Set
- Front
- Back
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Aminoglutethimide is used for the treatment of
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Cushing's Syndrome
Adrenal Hyperplasia Adrenal Cancer are treated with what? |
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What is the MOA of spironolactone?
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Inhibits the MC effect on the renal tubule to increase Na and Cl excretion, thereby decreasing BP.
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Side effects of Corticosteroid Antagonists
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Fatigue/Lethargy
Drowsiness Nausea Vomiting are side effects of what meds? |
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People who have
Diabetes Peptic Ulcer Osteoporosis Infection Pregnant should not use what? |
List the contraindications of Corticosteroids.
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Prednisone is contraindicated in patients with what condition?
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Liver dysfunction is a contraindication of what corticosteroid?
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Prednisone is used in the treatment of
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Myasthenia Gravis
Adrenal Insufficiency/Cancer |
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Triamcinolone is special because it does what?
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This corticosteroid does NOT suppress the HPA axis.
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Dexamethozone is used to treat what conditions?
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Addisonian Shock
Adrenal Insufficiency Short Term for RA Cushing's Dx STRONGEST anti-inflammatory |
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Betamethazone is used to treat what conditions?
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In topical form, this corticosteroid treats dermatoses.
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Beclomethazone is used to treat what condition?
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This corticosteroid is available as a NASAL inhalant to treat asthma.
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Hydrocortizone
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Short acting corticosteroid.
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Prednisolone
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Intermediate acting corticosteroid
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Prednisone
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Intermediate acting corticosteroid
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Methylprednisone
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Intermediate acting corticosteroid
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Triamcinolone
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Intermediate acting corticosteroid
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Dexamethazone
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Long acting corticosteroid
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Betamethazone
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Long acting corticosteroid
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Beclomethazone
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Long acting corticosteroid
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Methylprednizone Acetate is used to treat what?
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Intermediate acting corticosteroid for acute allergies
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Methylprednizone Succinate is used for what?
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This long acting corticosteroid is used for
emergencies (IV, PO, IM) short term asthma chronic and acute inflammation |
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List all the corticosteroids
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Hydrocortizone
Methylprednizone Acetate Methylprednizone Succinate Prednisolone Prednizone Triamcinolone Dexamethaxone Betamethazone Beclomethazone |
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List the corticosteroid antagonists
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Spironolactone
Aminoglutethimide |
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Aminoglutethimide
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Corticosteroid Antagonist
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Spironolactone
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Corticosteroid Antagonist
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What does cortisol do?
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(-) protein synthesis
(-) release of CRH and ACTH (+) glucose formation (+) fatty acid release |
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Aspirin
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Cyclooxygenase Inhibitor
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Ibuprofen
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Cyclooxygenase Inhibitor
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Indomethacin
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Cyclooxygenase Inhibitor
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Ketorolac
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Cyclooxygenase Inhibitor
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Naproxen
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Cyclooxygenase Inhibitor
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Piroxicam
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Cyclooxygenase Inhibitor
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Sulindac
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Cyclooxygenase Inhibitor
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Diclofenac
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Cyclooxygenase Inhibitor
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Name all the Cyclooxygenase Inhibitors
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Aspirin
Ibuprofen Indomethacin Ketorolac Naproxen Piroxicam Sulindac Diclofenac |
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Celecoxib
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Cyclooxygenase 2 Inhibitor
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NSAID with reduced incidence of GI side effects
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Celecoxib
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MOA of Aspirin Acetylsalicylic Acid
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Non-selective and irreversible inhibition of cyclooxygenase, and thus synthesis of prostaglandins and thromboxanes.
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Additional MOA of Aspirin Acetylsalicylic Acid
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Inhibit granulocyte adherance to vasculature
Stabilizes lysosomes Inhibits chemotaxis of polymorphonuclear leukocytes and macrophages |
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Acetylsalicylic Acid is used prophylactically with what conditions?
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Coronary Artery Disease
Deep Vein Thrombosis Unstable Angina Myocardial Infarction Stroke These can be prevented with |
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What is the drug of choice for antipyresis in children?
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Acetominophen can be used for what condition in children?
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Used as analgesic and anti-inflammatory in gout, RA, osteoarthritis.
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Ibuprofen
Naproxen What's the use? |
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Used as analgesic for osteoarthritis and musculoskeletal pain.
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How is Diflusinal used?
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Indomethacin is indicated in the
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Treats
-RA -Acute Gouty Arthritis -Osteoarthritis -Closure of PDA |
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Why is indomethacin so potent?
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Rapidly and Completely absorbed from GI tract
Highly bound to plasma proteins |
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What allows Sulindac to have 1-2 daily doses?
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Long half-life
prodrug metabolized in liver to sulfide metabolite |
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Dicolfenac is used for
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Long-term treatment of osteoarthritis and ankylosing spondylitis.
Short-term treatment of acute musculoskeletal and postop pain |
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NSAID used for dysmenorrhea, OA, RA, postop pain
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Celecoxib
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Long-term treatment of RA, OA, and acute gout with once daily dosing.
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Piroxicam
Meloxicam used for.... |
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Drugs displaced by NSAIDs on plasma proteins
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Anticoagulents
Phenytoin Sulfonamide Sulfonylureas |
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Contraindications of NSAIDs
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Third-trimester pregnancy
Comprised Renal Function Concomitant Anticoagulants Concomitant Corticosteroids |
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Side effects of COX-2 inhibitors
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increased risk of thrombosis, stroke, MI
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Side effects of NSAIDs
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Gastric and intestinal ulcers
Diarrhea Urticaria Increased stomach acid secretion (d/t inhibition of prostaglandin synthesis) |
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What meds can be prescribed as co-therapy to reduce NSAID induced GI injury?
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Misoprostol
High dose H2 Receptor Antagonist Proton Pump Inhibitor |
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Gout is the accumulation of what in the synovial fluid?
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Monosodium urate crystals accumulate in what condition?
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Drug of choice for acute gout attacks
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Indomethacin or Ibuprofen
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Second drug of choice for acute gout attack
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Naproxen and Diclofenac fall where in gout treatment?
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Colchicine has what MOA in the treatment of gout?
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Stops release of chemotactic factors, granulocyte migration, phagocyte activity, mast cell degranulation.
Duration of therapy limited by diarrhea, nausea, vomitting, bone marrow suppression. Acute only. |
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Allopurinol has what MOA in the treatment of gout?
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Inhibits xanthine oxidase to reduce plasma uric acid levels. Chronic only, avoid in acute cases.
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What is the active metabolite of allopurinol?
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Oxypurinol is the active metabolite of what drug?
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What is the MOA of probenicid in the treatment of gout?
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Blocks proximal tubular reabsorbtion of uric acid to lower serum levels. Twice daily with lots of fluid.
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