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18 Cards in this Set
- Front
- Back
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What is the MOA for statins?
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What class of meds inhibits HMG COA reductase, thus reducing hepatic cholesterol synthesis?
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Name the Statins in their respective categories.
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Specific Reversible competetive inhibitors
Fluvastatin Lovastatin Pravastatin Simvastatin Long lasting inhibitors Atorvastatin Rouvastatin |
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What prodrug is metabolized in the liver to its active form B-hydroxy fatty acid?
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Simvastatin
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Pregnant women cannot take what?
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Statins are contraindicated in who?
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Statins and fibrates can cause ____ commonly seen in patients lean body mass and hypothyroidism.
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Myositis is a classic effect of what drugs?
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What should you use with heterozygous hypercholesterolemia?
What should you use for homozygous hypercholesterolemia? |
Ezetimibe for ______.
Atorvastatin for ______. |
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Name the fibrates.
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Bezafibrate
Ciprofibrate Clofibrate Fenofibrate Gemfibrizil |
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Bile acid binding resins- name em'
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Colestyramine
Colestipol Colesevelam |
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What's the MOA for bile acid binding resins?
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These drugs sequester bile acids in intestine and prevent reabsorbtion/enterohepatic circulation.
Increase metab of endogenous cholesterol into bile acids. |
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What is a negative side effect of bile acid binding resins?
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Increase in TG level is an unwanted side effect of what drug?
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Bile acid binding resins should not be taken with what other meds?
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Warfarin
Digoxine Chlorthiazide Should not be taken with what? |
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Diarrhea
Elevated prothrombin time Decreased abs of fat solb vit- esp K Bleeding Gums The above are side effects of what drugs? |
bile acid binding resins adverse effects
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Ezetimide is contraindicated in who?
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Women who are breast feeding should not take what med?
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What med blocks the cholesterol transporter NPC1L1 in the duodenum?
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Ezetimide's MOA is what?
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Diarrhea
Headache Abdominal Pain Rash Angioedema are side effects of what? |
Ezetimide
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Nicotinic Acid Derivitives MOA is what?
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What inhibits hepatic triglyceride production and VLDL secretion?
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Niacin
Nicotinimide Nicobid Nicolar |
Name the Nicotinic Acid Derivitives.
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Flushing (prost D prod)
Palpitations GI Disturbances Impaired glucose tolerance (no-no for diabetics!) Precipitate GOUT |
Unwanted effects of Nicotinic Acid Derivitives
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