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18 Cards in this Set

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What is the MOA for statins?
What class of meds inhibits HMG COA reductase, thus reducing hepatic cholesterol synthesis?
Name the Statins in their respective categories.
Specific Reversible competetive inhibitors
Fluvastatin
Lovastatin
Pravastatin
Simvastatin

Long lasting inhibitors
Atorvastatin
Rouvastatin
What prodrug is metabolized in the liver to its active form B-hydroxy fatty acid?
Simvastatin
Pregnant women cannot take what?
Statins are contraindicated in who?
Statins and fibrates can cause ____ commonly seen in patients lean body mass and hypothyroidism.
Myositis is a classic effect of what drugs?
What should you use with heterozygous hypercholesterolemia?

What should you use for homozygous hypercholesterolemia?
Ezetimibe for ______.

Atorvastatin for ______.
Name the fibrates.
Bezafibrate
Ciprofibrate
Clofibrate
Fenofibrate
Gemfibrizil
Bile acid binding resins- name em'
Colestyramine
Colestipol
Colesevelam
What's the MOA for bile acid binding resins?
These drugs sequester bile acids in intestine and prevent reabsorbtion/enterohepatic circulation.

Increase metab of endogenous cholesterol into bile acids.
What is a negative side effect of bile acid binding resins?
Increase in TG level is an unwanted side effect of what drug?
Bile acid binding resins should not be taken with what other meds?
Warfarin
Digoxine
Chlorthiazide

Should not be taken with what?
Diarrhea
Elevated prothrombin time
Decreased abs of fat solb vit- esp K
Bleeding Gums

The above are side effects of what drugs?
bile acid binding resins adverse effects
Ezetimide is contraindicated in who?
Women who are breast feeding should not take what med?
What med blocks the cholesterol transporter NPC1L1 in the duodenum?
Ezetimide's MOA is what?
Diarrhea
Headache
Abdominal Pain
Rash
Angioedema

are side effects of what?
Ezetimide
Nicotinic Acid Derivitives MOA is what?
What inhibits hepatic triglyceride production and VLDL secretion?
Niacin
Nicotinimide
Nicobid
Nicolar
Name the Nicotinic Acid Derivitives.
Flushing (prost D prod)
Palpitations
GI Disturbances
Impaired glucose tolerance (no-no for diabetics!)
Precipitate GOUT
Unwanted effects of Nicotinic Acid Derivitives