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21 Cards in this Set

  • Front
  • Back
What is different between tertiary and quarternary amine anticholinergics?
tertiary can enter CNS
tx motion sickness
scopolamine- tertiary
used in ophthalmology- mydriasis and cycloplegia
homatropine- tertiary
used in Parkinsonism and for extrapyramidal side effects of antipsychotic agents
benzotropine
used for urinary incontinence (2)
oxybutyrin and tolterodine- tertiary
decrease bladder tone
tx peptic ulcers
pirenzipine- tertiary, M1 selective
decreases GI secretions, reduces motility, delays emptying
acts on GI tract
propantheline- quarternary
prophylactic for asthma (2)
ipratropium and tiotropium- quarternary
reduce bronchoconstriction
pre-anesthetic
glycopyrrolate- quarternary
This drug is M1, M3 selective- when taken by inhalation it has significantly longer duration (>24 hrs) of action relative to ipratropium
thiotropium
lowest atropine sensitivity organ to highest atropine sensitivity organ
secretory
eye and heart
GI and UT motility
GI secretion
CNS
atropine secretory effects
dec sweating
dec respiratory secretion
dec salivation
atropine eye and heart effects
mydriasis (dilation)
cycloplegia (paralysis of accomodation)
tachycardia
atropine GI and UT motility effects
dec gastric, intestinal, biliary, ureter and bladder smooth muscle contraction
atropine GI secretory effect
dec GI secretion
atropine CNS effect
excitation, delerium, medullary depression
atropine toxicity
Hot as a hare
Dry as a bone
Red as a beet
Blind as a bat
Mad as a hatter
3 plants where belladonna alkaloids may be found (atropine, scopolamine)
deadly nightshade
jimson-weed
henbane
tx for anti-muscarinic drug poisoning
anticholinesterase (inc ACh)
sedative for CNS (tertiary drugs only)
supportive
alcohol sponge for fever
is atropine absorbed well from GI tract?
yes- uncharged form readily absorbed
excreted in urine about 50% metabolized
(scopolamine 99% metabolized)
Anticholinergics
ABCD's
anorexia
blurry vision
constipation
confusion
dry mouth
sedation
stasis of urine