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14 Cards in this Set

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Choline ester that is not use clinically because it is too indiscriminate and too rapidly hydrolyzed by cholinesterase
ACh
ACh low dose vs. high dose
low dose- M-selective
high dose- M and N
choline ester, slowly hydrolyzed, not used clinically
M and N effects
carbachol
choline ester
slowly hydrolyzed
weak N activity
metacholine
muscarinic agonist may be used to tx
urinary retention
abdominal distension
adynamic ileum
gastric atony
bethanechol
from amanita muscaria, not used clinically
muscarine
natural alkaloid used as a
topical miotic
tx glaucoma
pilocarpine
active agent of inocybe species
high conc. muscarine
sx of inocybe poisoning and tx
fast onset- salivation, lacrimation, nausea, vomiting, headache, diarrhea, dyspnea, bradycardia, hypotension, shock

atropine
active agent of amanita muscaria
low conc muscarine
ibotenic acid
sx of amanita muscaria poisoning and tx
fast onset- like inocybe (salivation, lacrimation, nausea, vomiting, headache, diarrhea, dyspnea, bradycardia, hypotension, shock)
+ CNS: irritability, restlessness, ataxia, anxiety, mania, hallucinations, convulsions, delirium

tx- sedatives
active agent of amanita phalloides
cyclic peptides: phallatoxins and amatoxins
sx of amanita phalloides poisoning and tx
slow onset- liver and renal damage; grave prognosis

supportive tx
Cholinergic effects
LESS DUMB
lacrimation
excitation of N synapses
salivation
sweating
diarrhea
urinartion
micturition
bronchoconstriction