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14 Cards in this Set
- Front
- Back
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Choline ester that is not use clinically because it is too indiscriminate and too rapidly hydrolyzed by cholinesterase
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ACh
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ACh low dose vs. high dose
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low dose- M-selective
high dose- M and N |
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choline ester, slowly hydrolyzed, not used clinically
M and N effects |
carbachol
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choline ester
slowly hydrolyzed weak N activity |
metacholine
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muscarinic agonist may be used to tx
urinary retention abdominal distension adynamic ileum gastric atony |
bethanechol
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from amanita muscaria, not used clinically
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muscarine
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natural alkaloid used as a
topical miotic tx glaucoma |
pilocarpine
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active agent of inocybe species
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high conc. muscarine
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sx of inocybe poisoning and tx
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fast onset- salivation, lacrimation, nausea, vomiting, headache, diarrhea, dyspnea, bradycardia, hypotension, shock
atropine |
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active agent of amanita muscaria
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low conc muscarine
ibotenic acid |
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sx of amanita muscaria poisoning and tx
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fast onset- like inocybe (salivation, lacrimation, nausea, vomiting, headache, diarrhea, dyspnea, bradycardia, hypotension, shock)
+ CNS: irritability, restlessness, ataxia, anxiety, mania, hallucinations, convulsions, delirium tx- sedatives |
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active agent of amanita phalloides
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cyclic peptides: phallatoxins and amatoxins
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sx of amanita phalloides poisoning and tx
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slow onset- liver and renal damage; grave prognosis
supportive tx |
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Cholinergic effects
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LESS DUMB
lacrimation excitation of N synapses salivation sweating diarrhea urinartion micturition bronchoconstriction |
