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19 Cards in this Set

  • Front
  • Back
peptide with NE
NPY
peptide with ACh
VIP
acetyl CoA + choline
--> acetylcholine
choline acetyltransferase (CAT)
acetylcholine
--> acetate + choline
acetylcholinesterase (AChE)
Tyrosine to Epi
Tyrosine
DOPA
DA
NE
Epi
tyrosine to dopa
enzyme- tyrosine hydroxylase
use tetrahydrobiopterin

*Rate limiting step*
dopa to DA
enzyme- L-AAD
use- PP
DA to Epi
enzyme- Dopamine Beta Hydroxylase
use- ascorbate
NE to Epi
enzyme- PNMT (only in adrenal medulla and a few epi containing pathways in brain stem)

use- SAM
transported into sympathetic nerve
tyrosine
transported into sympathetic nerve vesicles

inhibited by...
DA

reserpine
NE release inhibited by
guanethidine
bretylium
most important mechanism for terminatin of action of NE

blocked by...
active reuptake into nerve terminal

cocaine
tricyclic antidepressants
anti-obesity
Where is MAO
mito, especially in CNS
where is COMT
cytoplasm
transported into parasympathetic neuron

inhibited by
choline

hemicholinium
blocks ACh release from vesicles

forces ACh release from vesicles
botulinum acting at VAMPS or SNAPS

black widow poison
parasympathetic preganglionic fibers are
long/short

come from where?

ration of pre:post
long

CN nuclei III, VII, IX, X
S2-S4

1:1
sympathetic preganglionic fibers are long/short

come from where?

ratio of pre:post

post-ganglionic fibers...
short

T1-T12
L1-L5

1:20

unmyelinated!