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11 Cards in this Set
- Front
- Back
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liver cirrhosis
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coagulation proteins synthesized in liver
caused by ETOH abuse, hepatitis characterized by ascites (fluid in peritoneum) |
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liver tests
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AST and ALT may be normal
ultrasound-shrunken, nodular liver liver biopsy-best sensitivity |
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disseminated intravascular coagulation (DIC)
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leads to bleeding diathesis or thrombosis
manifestations-bleeding, jaundice, renal failure, coma, pulmonary hemorrhage |
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DIC lab testing
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decreased serum fibrinogen
elevated fibrin degradation products and D-dimer thrombocytopenia elevatated PT and aPTT |
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DIC management
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treat underlying cause (e.g. antibiotics for sepsis)
administer plately and fresh frozen plasma heparin |
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anticoagulants
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heparin-potentiates action of antithrombin to inactivate thrombin
coumadin (warfarin)-inhibits vit. K activity argatroban-direct thrombin inhibitor |
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vitamin K
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found in green vegetables
produced by intestinal bacteria activates coagulation factors II, VII, IX, X, and proteins C and S bone mineralization |
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Vit K deficiency causes
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antibiotics (reducing intestinal bacteria)
prolonged starvation parenteral nutrition coumadin-like anticoagulants |
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vit K symptoms
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easy bruising, mucosal bleeding, melena, hamaturia
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treatment
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daily requirements: 90-100 mcg
treatment-administer 1-25mg vit K (PO, IM, SC, IV) |
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working diagnosis
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platelet count
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